Question 1

What can be done to prevent the development of HLA alloimmunization and platelet refractoriness?

Accepted Answer

A)  Test the donor for the presence of platelet antibodies. 
B)  Issue only cytomegalovirus-negative platelets. 
C)  Irradiate the platelet concentrate. 
D)  Reduce the number of leukocytes in the platelet product. 
A)  Test the donor for the presence of platelet antibodies. 
B)  Issue only cytomegalovirus-negative platelets. 
C)  Irradiate the platelet concentrate. 
D)  Reduce the number of leukocytes in the platelet product.

Question 2

Citrate used as an anticoagulant in apheresis procedures is removed from the body by:

Accepted Answer

A)  the kidneys. 
B)  being metabolized in the liver. 
C)  sweating. 
D)  none of the above. 
A)  the kidneys. 
B)  being metabolized in the liver. 
C)  sweating. 
D)  none of the above.

Question 3

All of the following constitute variables of apheresis procedures except:

Accepted Answer

A)  centrifuge speed. 
B)  anticoagulant. 
C)  length of blood dwell time in centrifuge. 
D)  blood type. 
A)  centrifuge speed. 
B)  anticoagulant. 
C)  length of blood dwell time in centrifuge. 
D)  blood type.

Question 4

Which of the following statements best describes the apheresis concept?

Accepted Answer

A)  Blood is removed from an individual and separated, the desired component is retained, and the remaining portions are returned to the donor/patient. 
B)  Blood is removed from an individual, the desired component is retained, anticoagulated, and separated, and the remaining portion is returned to the donor/patient. 
C)  Blood is removed from an individual, anticoagulated, and separated, the desired component is retained, and the remaining portions are returned to the donor/patient. 
D)  None of the above 
A)  Blood is removed from an individual and separated, the desired component is retained, and the remaining portions are returned to the donor/patient. 
B)  Blood is removed from an individual, the desired component is retained, anticoagulated, and separated, and the remaining portion is returned to the donor/patient. 
C)  Blood is removed from an individual, anticoagulated, and separated, the desired component is retained, and the remaining portions are returned to the donor/patient. 
D)  None of the above

Question 5

Which patients are at the most risk for platelet refractoriness where they become alloimmunized to HLA antigens on platelets?

Accepted Answer

A)  Patients with liver disease 
B)  Cardiac patients 
C)  Leukemic patients 
D)  Kidney transplant patients 
A)  Patients with liver disease 
B)  Cardiac patients 
C)  Leukemic patients 
D)  Kidney transplant patients

Question 6

The concentrate obtained from plateletpheresis via a closed system is stored for 5 days at room temperature. What must the pH be at the end of storage?

Accepted Answer

A)  >=5.0 
B)  >=6.0 
C)  >=4.0 
D)  >=8.0 
A)  >=5.0 
B)  >=6.0 
C)  >=4.0 
D)  >=8.0

Question 7

Photopheresis is effective against what malignant disorder?

Accepted Answer

A)  Hairy cell leukemia 
B)  Cutaneous T-cell lymphoma 
C)  Hodgkin's lymphoma 
D)  Acute lymphocytic leukemia 
A)  Hairy cell leukemia 
B)  Cutaneous T-cell lymphoma 
C)  Hodgkin's lymphoma 
D)  Acute lymphocytic leukemia

Question 8

Fatalities that result from therapeutic apheresis have primarily been caused by:

Accepted Answer

A)  cardiac arrest and arrhythmia. 
B)  stroke. 
C)  seizure. 
D)  renal failure. 
A)  cardiac arrest and arrhythmia. 
B)  stroke. 
C)  seizure. 
D)  renal failure.

Question 9

What variables are necessary to calculate the donor's total blood volume?

Accepted Answer

A)  Height 
B)  Weight 
C)  Sex 
D)  All of the above 
A)  Height 
B)  Weight 
C)  Sex 
D)  All of the above

Question 10

What is therapeutic plasmapheresis?

Accepted Answer

A)  The removal of large volumes of patient plasma 
B)  The removal of minute volumes of patient plasma 
C)  The removal of plasma containing anti-D 
D)  The removal of plasma containing immunoglobulin 
A)  The removal of large volumes of patient plasma 
B)  The removal of minute volumes of patient plasma 
C)  The removal of plasma containing anti-D 
D)  The removal of plasma containing immunoglobulin

Question 11

What is an example of a continuous flow centrifugation (CFC) instrument?

Accepted Answer

A)  Haemonetics V50 
B)  COBE Spectra 
C)  Fenwal Autopheresis-C 
D)  Haemonetics V30 
A)  Haemonetics V50 
B)  COBE Spectra 
C)  Fenwal Autopheresis-C 
D)  Haemonetics V30

Question 12

During a plasmapheresis procedure, the red blood cells must be returned within how many hours of phlebotomy?

Accepted Answer

A)  2 hours 
B)  4 hours 
C)  6 hours 
D)  8 hours 
A)  2 hours 
B)  4 hours 
C)  6 hours 
D)  8 hours

Question 13

When is isolation of PBSCs via apheresis equipment indicated?

Accepted Answer

A)  The bone marrow contains malignant cells 
B)  The bone marrow has been irradiated 
C)  The patient cannot tolerate general anesthesia 
D)  All of the above 
A)  The bone marrow contains malignant cells 
B)  The bone marrow has been irradiated 
C)  The patient cannot tolerate general anesthesia 
D)  All of the above

Question 14

Which of the following is an indication for therapeutic apheresis?

Accepted Answer

A)  Collection of neocytes to reduce the number of transfusions in patient with thalassemia major 
B)  A pathogenic substance exists in the blood that contributes to a disease process. 
C)  A substance can be more effectively removed by apheresis than by the body's own homeostatic mechanisms. 
D)  Options B and C 
A)  Collection of neocytes to reduce the number of transfusions in patient with thalassemia major 
B)  A pathogenic substance exists in the blood that contributes to a disease process. 
C)  A substance can be more effectively removed by apheresis than by the body's own homeostatic mechanisms. 
D)  Options B and C

Question 15

What does the hematocrit need to be (regardless of gender) for a double red blood cell collection?

Accepted Answer

A)  25% 
B)  45% 
C)  40% 
D)  35% 
A)  25% 
B)  45% 
C)  40% 
D)  35%

Question 16

Antiplatelet medications have differing deferral time periods. Which of the following does not match?

Accepted Answer

A)  Aspirin-48 hours 
B)  Plavix-14 days 
C)  Feldene-7 days 
D)  Ticlid-14 days 
A)  Aspirin-48 hours 
B)  Plavix-14 days 
C)  Feldene-7 days 
D)  Ticlid-14 days

Question 17

Currently, the immunoaffinity column has FDA licensure for treating what disease state?

Accepted Answer

A)  Hemolytic uremic syndrome 
B)  TTP 
C)  AIDS 
D)  Idiopathic thrombocytopenic purpura (ITP) 
A)  Hemolytic uremic syndrome 
B)  TTP 
C)  AIDS 
D)  Idiopathic thrombocytopenic purpura (ITP)

Question 18

Which cell type is densest in the white blood cell layer when anticoagulated blood is centrifuged?

Accepted Answer

A)  Granulocyte 
B)  Monocyte 
C)  Lymphocyte 
D)  Platelets 
A)  Granulocyte 
B)  Monocyte 
C)  Lymphocyte 
D)  Platelets

Question 19

A child undergoing apheresis may require CFC to minimize:

Accepted Answer

A)  extracorporeal volume. 
B)  extravascular volume. 
C)  intracorporeal volume. 
D)  extramedullary volume. 
A)  extracorporeal volume. 
B)  extravascular volume. 
C)  intracorporeal volume. 
D)  extramedullary volume.

Question 20

How is HES used in apheresis procedures?

Accepted Answer

A)  As a chelation agent to bind calcium 
B)  As a sedimenting agent to separate white blood cells from red blood cells 
C)  As a primer to keep infusion lines open 
D)  As a hemolysin to lyse red blood cells 
A)  As a chelation agent to bind calcium 
B)  As a sedimenting agent to separate white blood cells from red blood cells 
C)  As a primer to keep infusion lines open 
D)  As a hemolysin to lyse red blood cells

Exam 14: Apheresis

What can be done to prevent the development of HLA alloimmunization and platelet refractoriness?

Citrate used as an anticoagulant in apheresis procedures is removed from the body by:

All of the following constitute variables of apheresis procedures except:

Which of the following statements best describes the apheresis concept?

Which patients are at the most risk for platelet refractoriness where they become alloimmunized to HLA antigens on platelets?

The concentrate obtained from plateletpheresis via a closed system is stored for 5 days at room temperature. What must the pH be at the end of storage?

Photopheresis is effective against what malignant disorder?

Fatalities that result from therapeutic apheresis have primarily been caused by:

What variables are necessary to calculate the donor's total blood volume?

What is therapeutic plasmapheresis?

What is an example of a continuous flow centrifugation (CFC) instrument?

During a plasmapheresis procedure, the red blood cells must be returned within how many hours of phlebotomy?

When is isolation of PBSCs via apheresis equipment indicated?

Which of the following is an indication for therapeutic apheresis?

What does the hematocrit need to be (regardless of gender) for a double red blood cell collection?

Antiplatelet medications have differing deferral time periods. Which of the following does not match?

Currently, the immunoaffinity column has FDA licensure for treating what disease state?

Which cell type is densest in the white blood cell layer when anticoagulated blood is centrifuged?

A child undergoing apheresis may require CFC to minimize:

How is HES used in apheresis procedures?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

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