Exam 14: Molecular Oncology

This test is used to determine if the mismatch repair system is functioning normally.

What genes are most likely mutated in inherited colon cancer with microsatellite instability?

Gene expression patterns are now used to characterize tumor types. What method is appropriate for analysis of expression of many genes simultaneously?

Malignant tissue originating in one organ (primary) site is isolated from a different organ. How would this malignancy be described?

Which of the following translocations results in the overexpression of the intact translocated gene as opposed to formation of an abnormally functional fusion protein?

Herceptin (trastuzumab) therapy works best on what tumors?

Which of the following is a clinical test to help determine optimal therapeutic use of EGFR inhibitors in lung cancer?

What type of mutations usually occur in tumor suppressor genes in malignant cells?

These genes form a dimeric enzyme that catalyzes decarboxylation of isocitrate into alpha-ketoglutarate.

This gene is frequently tested with K-ras and works on the same pathway downstream of K-ras in colon cancer.

A patient with a family history of breast cancer wants to know her risk of having breast cancer. Which of the following genes should be analyzed in this patient?

Which of the following translocations can be used to monitor treatment for chronic myelogenous leukemia?

T-cell receptor gene rearrangements were analyzed by PCR using forward and reverse primers complementary to the V_1 and J_1 regions, respectively, of the T-cell receptor gene region. The products were separated by polyacrylamide gel electrophoresis and bands visualized using ethidium bromide. The lane corresponding to the patient had a sharp band. All controls were acceptable. How is this result interpreted?

What would be observed in the event of loss of heterozygosity?

A PCR assay is performed on a patient with presumptive mantle cell lymphoma using primers against the immunoglobulin heavy chain gene and the cyclin D1 (CCND1) gene. Capillary gel electrophoresis was used for product detection, and the patient did not have a detectable PCR product. All controls were acceptable. Which of the following is the correct interpretation of this result?

Which of the following translocations is associated with acute promyelocytic leukemia (APL)?

Specific translocations involving the EWS gene at 22q12 are useful for diagnosis of what types of tumors?

Mutations in the VHL gene are associated with what condition?

A patient is suspected of having follicular lymphoma, and his physician would like additional laboratory tests performed to confirm or rule out the diagnosis. Which of the following tests should be performed?

Fusions of FKHR and the paired box genes (PAX3 and PAX7) are frequently found in what tumors?