Question 1

What is a xenograft?

Accepted Answer

A) transplanting cells in the presence of xenon 
B) transplant of cells from one organism to an organism of a different species 
C) mixing cells from two different species in a culture dish 
D) a transplant that does not have a good histocompatibility antigen match 
E) a skin graft from one organism to another within the same species 
A) transplanting cells in the presence of xenon 
B) transplant of cells from one organism to an organism of a different species 
C) mixing cells from two different species in a culture dish 
D) a transplant that does not have a good histocompatibility antigen match 
E) a skin graft from one organism to another within the same species B

Question 2

________ is a humanized antibody directed against a cell surface receptor called _____ that binds a growth factor responsible for stimulating the proliferation of breast cancer cells.

Accepted Answer

A) Ascriptin,Asc3 
B) Herceptin,Her2 
C) Apcolin,Apc2 
D) Herceptin.Raf 
E) Rafinolin,Raf 
A) Ascriptin,Asc3 
B) Herceptin,Her2 
C) Apcolin,Apc2 
D) Herceptin.Raf 
E) Rafinolin,Raf B

Question 3

The genes involved in tumorigenesis constitute a specific subset of the genome whose products are involved in which of the following activities?

Accepted Answer

A) progression of a cell through the cell cycle 
B) adhesion of a cell to its neighbors 
C) apoptosis 
D) repair of DNA damage 
E) All of these are correct. 
A) progression of a cell through the cell cycle 
B) adhesion of a cell to its neighbors 
C) apoptosis 
D) repair of DNA damage 
E) All of these are correct. E

Question 4

The avian erythroblastosis virus contains an oncogene called erbB that encodes ___________.

Accepted Answer

A) an altered EGF receptor that is missing part of the extracellular domain that binds to the growth factor 
B) an altered insulin receptor that binds insulin with lower affinity 
C) an altered transcription factor that turns on hemoglobin synthesis 
D) an elongated auxiliary protein of the cytoskeleton 
E) an underexpressed nuclear protein 
A) an altered EGF receptor that is missing part of the extracellular domain that binds to the growth factor 
B) an altered insulin receptor that binds insulin with lower affinity 
C) an altered transcription factor that turns on hemoglobin synthesis 
D) an elongated auxiliary protein of the cytoskeleton 
E) an underexpressed nuclear protein

Question 5

Why can cancer cells proliferate in the absence of serum?

Accepted Answer

A) Their nuclei depend on these serum growth factors to maintain their structure. 
B) The serum inhibits their growth,while it is necessary for normal cells. 
C) The cell cycle of cancer cells does not depend on signals transmitted from serum growth-factor receptors located at their surface. 
D) The cell cycle of cancer cells depends on signals transmitted from serum growth-factor receptors located in their cytoplasm. 
E) Their mitochondria depend on serum growth factors for their activity. 
A) Their nuclei depend on these serum growth factors to maintain their structure. 
B) The serum inhibits their growth,while it is necessary for normal cells. 
C) The cell cycle of cancer cells does not depend on signals transmitted from serum growth-factor receptors located at their surface. 
D) The cell cycle of cancer cells depends on signals transmitted from serum growth-factor receptors located in their cytoplasm. 
E) Their mitochondria depend on serum growth factors for their activity.

Question 6

With respect to cancer genetics and the cancer genome,what are passenger genes?

Accepted Answer

A) genes that are subject to mutation but have no effect on the phenotype of a cancer cell 
B) genes that are not subject to mutation and have no effect on the phenotype of a cancer cell 
C) genes that are subject to mutation but have a large effect on the phenotype of a cancer cell 
D) genes that are subject to mutation but have no effect on the genotype of a cancer cell 
E) genes that are subject to mutation but have no effect on the phenotype of an egg cell 
A) genes that are subject to mutation but have no effect on the phenotype of a cancer cell 
B) genes that are not subject to mutation and have no effect on the phenotype of a cancer cell 
C) genes that are subject to mutation but have a large effect on the phenotype of a cancer cell 
D) genes that are subject to mutation but have no effect on the genotype of a cancer cell 
E) genes that are subject to mutation but have no effect on the phenotype of an egg cell

Question 7

Against what protein is the treatment for metastatic colon cancer Vectibix directed?

Accepted Answer

A) pRB 
B) p53 
C) the EGF receptor 
D) VEGF 
E) Her2 
A) pRB 
B) p53 
C) the EGF receptor 
D) VEGF 
E) Her2

Question 8

Normal cells greatly slow their rates of cell division after filling a culture dish with a layer one cell deep (a monolayer).If a circular group of cells is removed from the middle of the filled culture dish,the cells on the edges of the "wound" will begin to divide,fill the space and then stop dividing again.How does the behavior of transformed cells differ?

Accepted Answer

Transformed cells do not exhibit such be

Question 9

If patients with advanced CML are initially treated with Gleevec,they generally develop resistance to the drug within a few months.What seems to cause the resistance?

Accepted Answer

A) mutations in the BCR portion of the fusion gene 
B) mutations in the ABL portion of the fusion gene 
C) ABL gene deletion 
D) ABL gene amplification 
E) BCR gene amplification 
A) mutations in the BCR portion of the fusion gene 
B) mutations in the ABL portion of the fusion gene 
C) ABL gene deletion 
D) ABL gene amplification 
E) BCR gene amplification

Question 10

The first oncogene discovered was _____,which codes for a _______.

Accepted Answer

A) MYC,tyrosine protein kinase 
B) SRC,tyrosine protein kinase 
C) SRC,serine/threonine protein kinase 
D) MYC,serine/threonine protein kinase 
E) SRC,intermediary metabolism regulatory protein 
A) MYC,tyrosine protein kinase 
B) SRC,tyrosine protein kinase 
C) SRC,serine/threonine protein kinase 
D) MYC,serine/threonine protein kinase 
E) SRC,intermediary metabolism regulatory protein

Question 11

What do all of the environmental agents that can cause cancer have in common?

Accepted Answer

A) They can all alter the genome. 
B) They are all soluble in water. 
C) They are all made of nucleic acids. 
D) They are all made of amino acids. 
E) They all can alter proteins present in the cell cytoplasm that are responsible for the onset of cancer. 
A) They can all alter the genome. 
B) They are all soluble in water. 
C) They are all made of nucleic acids. 
D) They are all made of amino acids. 
E) They all can alter proteins present in the cell cytoplasm that are responsible for the onset of cancer.

Question 12

What enzyme is responsible for maintaining the length of the DNA sequences on the ends of chromosomes (telomeres)?

Accepted Answer

A) tendrilase 
B) telomerase 
C) telomere synthase 
D) telomere disruptase 
E) telomere kinase 
A) tendrilase 
B) telomerase 
C) telomere synthase 
D) telomere disruptase 
E) telomere kinase

Question 13

The cancer vaccine Provenge has been designed to teach a person's immune cells to attack what enzyme?

Accepted Answer

A) prostatic acid phosphatase 
B) alkaline phosphatase 
C) catalase 
D) telomerase 
E) reverse transcriptase 
A) prostatic acid phosphatase 
B) alkaline phosphatase 
C) catalase 
D) telomerase 
E) reverse transcriptase

Question 14

p53 remains in the nucleus,instead of being transported into the cytosol.

Accepted Answer

A) 4 - 5 - 3 - 1 - 6 - 2 
B) 4 - 3 - 5 - 1 - 6 - 2 
C) 4 - 3 - 5 - 2 - 1 - 6 
D) 4 - 1 - 3 - 5 - 6 - 2 
E) 3 - 5 - 4 - 1 - 6 - 2 
A) 4 - 5 - 3 - 1 - 6 - 2 
B) 4 - 3 - 5 - 1 - 6 - 2 
C) 4 - 3 - 5 - 2 - 1 - 6 
D) 4 - 1 - 3 - 5 - 6 - 2 
E) 3 - 5 - 4 - 1 - 6 - 2

Question 15

What is the material called serum that is added to culture media?

Accepted Answer

A) any sugary solution 
B) the fluid fraction of the blood 
C) the particulate fraction of the blood 
D) the combination of the fluid and particulate fractions of the blood 
E) any blood that has been in a syringe 
A) any sugary solution 
B) the fluid fraction of the blood 
C) the particulate fraction of the blood 
D) the combination of the fluid and particulate fractions of the blood 
E) any blood that has been in a syringe

Question 16

Which one of the following viruses does not appear to be linked to human cancers?

Accepted Answer

A) hepatitis B virus 
B) Epstein-Barr virus 
C) herpes virus HHV-8 
D) SV40 
E) rhinovirus 
A) hepatitis B virus 
B) Epstein-Barr virus 
C) herpes virus HHV-8 
D) SV40 
E) rhinovirus

Question 17

____________ is a rare childhood cancer of the eye's retina.

Accepted Answer

A) Retinal carcinoma 
B) Eye cancer 
C) Retinal sarcoma 
D) Retinoblastoma 
E) Retinal epithelioma 
A) Retinal carcinoma 
B) Eye cancer 
C) Retinal sarcoma 
D) Retinoblastoma 
E) Retinal epithelioma

Question 18

Who made the first known correlation between environmental agents and cancer development?

Accepted Answer

A) Harry Potter 
B) Percivall Pott 
C) Percival Lowell 
D) Charles Darwin 
E) Archibald Garrod 
A) Harry Potter 
B) Percivall Pott 
C) Percival Lowell 
D) Charles Darwin 
E) Archibald Garrod

Question 19

__________ is an approach that tries to get the immune system more involved in the fight against cancer.

Accepted Answer

A) Immunotherapy 
B) Gene therapy 
C) Inhibition of cancer-promoting proteins 
D) Inhibition of angiogenesis 
E) Hyposensitization 
A) Immunotherapy 
B) Gene therapy 
C) Inhibition of cancer-promoting proteins 
D) Inhibition of angiogenesis 
E) Hyposensitization

Question 20

How does PTEN affect the balance between proapoptotic and antiapoptotic signals?

Accepted Answer

A) PTEN removes the phosphate group from the 3-position of PIP3 converting it to PI(4,5)P2,which cannot activate PKB (AKT)and thus throws the balance in an antiapoptotic direction. 
B) PTEN removes the phosphate group from the 3-position of PIP3 converting it to PI(4,5)P2,which cannot activate PKB (AKT)and thus throws the balance in a proapoptotic direction. 
C) PTEN cuts a phosphate group off of PKB,which throws the balance in a proapoptotic direction. 
D) PTEN cuts a phosphate group off of PKB,which throws the balance in an antiapoptotic direction. 
E) PTEN adds a phosphate group to PKB,which throws the balance in a proapoptotic direction. 
A) PTEN removes the phosphate group from the 3-position of PIP3 converting it to PI(4,5)P2,which cannot activate PKB (AKT)and thus throws the balance in an antiapoptotic direction. 
B) PTEN removes the phosphate group from the 3-position of PIP3 converting it to PI(4,5)P2,which cannot activate PKB (AKT)and thus throws the balance in a proapoptotic direction. 
C) PTEN cuts a phosphate group off of PKB,which throws the balance in a proapoptotic direction. 
D) PTEN cuts a phosphate group off of PKB,which throws the balance in an antiapoptotic direction. 
E) PTEN adds a phosphate group to PKB,which throws the balance in a proapoptotic direction.

What is a xenograft?

____ is a humanized antibody directed against a cell surface receptor called _ that binds a growth factor responsible for stimulating the proliferation of breast cancer cells.

The genes involved in tumorigenesis constitute a specific subset of the genome whose products are involved in which of the following activities?

The avian erythroblastosis virus contains an oncogene called erbB that encodes ___________.

Why can cancer cells proliferate in the absence of serum?

With respect to cancer genetics and the cancer genome,what are passenger genes?

Against what protein is the treatment for metastatic colon cancer Vectibix directed?

If patients with advanced CML are initially treated with Gleevec,they generally develop resistance to the drug within a few months.What seems to cause the resistance?

The first oncogene discovered was _,which codes for a ___.

What do all of the environmental agents that can cause cancer have in common?

What enzyme is responsible for maintaining the length of the DNA sequences on the ends of chromosomes (telomeres)?

The cancer vaccine Provenge has been designed to teach a person's immune cells to attack what enzyme?

p53 remains in the nucleus,instead of being transported into the cytosol.

What is the material called serum that is added to culture media?

Which one of the following viruses does not appear to be linked to human cancers?

____________ is a rare childhood cancer of the eye's retina.

Who made the first known correlation between environmental agents and cancer development?

__________ is an approach that tries to get the immune system more involved in the fight against cancer.

How does PTEN affect the balance between proapoptotic and antiapoptotic signals?

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes, and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters

Exam 16: Cancer

What is a xenograft?

________ is a humanized antibody directed against a cell surface receptor called _____ that binds a growth factor responsible for stimulating the proliferation of breast cancer cells.

The genes involved in tumorigenesis constitute a specific subset of the genome whose products are involved in which of the following activities?

The avian erythroblastosis virus contains an oncogene called erbB that encodes ___________.

Why can cancer cells proliferate in the absence of serum?

With respect to cancer genetics and the cancer genome,what are passenger genes?

Against what protein is the treatment for metastatic colon cancer Vectibix directed?

If patients with advanced CML are initially treated with Gleevec,they generally develop resistance to the drug within a few months.What seems to cause the resistance?

The first oncogene discovered was _____,which codes for a _______.

What do all of the environmental agents that can cause cancer have in common?

What enzyme is responsible for maintaining the length of the DNA sequences on the ends of chromosomes (telomeres)?

The cancer vaccine Provenge has been designed to teach a person's immune cells to attack what enzyme?

p53 remains in the nucleus,instead of being transported into the cytosol.

What is the material called serum that is added to culture media?

Which one of the following viruses does not appear to be linked to human cancers?

____________ is a rare childhood cancer of the eye's retina.

Who made the first known correlation between environmental agents and cancer development?

__________ is an approach that tries to get the immune system more involved in the fight against cancer.

How does PTEN affect the balance between proapoptotic and antiapoptotic signals?

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes, and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters

____ is a humanized antibody directed against a cell surface receptor called _ that binds a growth factor responsible for stimulating the proliferation of breast cancer cells.

The first oncogene discovered was _,which codes for a ___.