Exam 13: Failures of Host Defense Mechanisms

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Human genome-wide genetic association (GWAS) studies have identified several genetic polymorphisms that contribute to HIV control, and the rate of disease progression to AIDS. Which two immune cell subsets are implicated by these data as important regulators of HIV replication and the rate of disease progression?

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Defects in components of the complement pathway do not lead to recurrent or persistent virus infections.

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A common misconception is that our immune system fails to make a productive immune response to HIV infection, thereby leading to chronic infection. In fact, following a primary HIV infection, our immune system:

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