Question 1

Which medication requires complete blood count monitoring due to the increased risk of aplastic anemia?

Accepted Answer

A) olanzapine (Zyprexa) 
B) aripiprazole (Abilify) 
C) carbamazepine (Tegretol) 
D) duloxetine (Cymbalta) 
A) olanzapine (Zyprexa) 
B) aripiprazole (Abilify) 
C) carbamazepine (Tegretol) 
D) duloxetine (Cymbalta) C

Question 2

Which drug can be used to help treat neuroleptic malignant syndrome (NMS)?

Accepted Answer

A) dantrolene (Dantrium) 
B) fluoxetine (Prozac) 
C) perphenazine (Trialfon) 
D) thioridazine (Mellaril) 
A) dantrolene (Dantrium) 
B) fluoxetine (Prozac) 
C) perphenazine (Trialfon) 
D) thioridazine (Mellaril) A

Question 3

The common antidepressant fluoxetine is considered to be in what FDA safety category?

Accepted Answer

A) Category A 
B) Category B 
C) Category C 
D) Category D 
A) Category A 
B) Category B 
C) Category C 
D) Category D B

Question 4

Trazodone (Desyrel)should be taken in divided doses because it can increase the concentration of which drug?

Accepted Answer

A) warfarin (Coumadin) 
B) alprazolam (Xanax) 
C) amitriptyline (Elavil) 
D) amoxapine (Asendin) 
A) warfarin (Coumadin) 
B) alprazolam (Xanax) 
C) amitriptyline (Elavil) 
D) amoxapine (Asendin)

Question 5

Which option best describes the mechanism of action of SSRIs?

Accepted Answer

A) Competitively block postsynaptic dopamine receptors 
B) Block neuronal reuptake of norepinephrine and serotonin at the presynaptic terminals 
C) Nonselectively inhibit the enzyme monoamine oxidase in its CNS storage sites 
D) Selectively inhibit 5-HT neuronal reuptake at selected nerve terminals in the CNS 
A) Competitively block postsynaptic dopamine receptors 
B) Block neuronal reuptake of norepinephrine and serotonin at the presynaptic terminals 
C) Nonselectively inhibit the enzyme monoamine oxidase in its CNS storage sites 
D) Selectively inhibit 5-HT neuronal reuptake at selected nerve terminals in the CNS

Question 6

Which drug has been used in the treatment of Tourette's syndrome?

Accepted Answer

A) aripiprazole (Abilify) 
B) pimozide (Orap) 
C) risperidone (Risperdal) 
D) ziprasidone (Geodon) 
A) aripiprazole (Abilify) 
B) pimozide (Orap) 
C) risperidone (Risperdal) 
D) ziprasidone (Geodon)

Question 7

Which drug is a tricyclic antidepressant that is preferred in the treatment of severely depressed patients who are anxious and agitated,specifically because of its sedating effect?

Accepted Answer

A) doxepin (Silenor) 
B) protriptyline (Vivactil) 
C) sertraline (Zoloft) 
D) venlafaxine (Effexor) 
A) doxepin (Silenor) 
B) protriptyline (Vivactil) 
C) sertraline (Zoloft) 
D) venlafaxine (Effexor)

Question 8

When starting a patient on imipramine (Tofranil),how long should it take for the antidepressant clinical effects to appear?

Accepted Answer

A) 24 hours 
B) 3 days 
C) 5 to 7 days 
D) 14 to 60 days 
A) 24 hours 
B) 3 days 
C) 5 to 7 days 
D) 14 to 60 days

Question 9

Which of the following drugs is used to manage both positive and negative mood symptoms of schizophrenia because of the low incidence of side effects and increased safety profile over clozapine (Clozaril)?

Accepted Answer

A) fluphenazine (Prolixin) 
B) doxepin (Silenor) 
C) venlafaxine (Effexor) 
D) olanzapine (Zyprexa) 
A) fluphenazine (Prolixin) 
B) doxepin (Silenor) 
C) venlafaxine (Effexor) 
D) olanzapine (Zyprexa)

Question 10

Which selective serotonin reuptake inhibitor (SSRI)is used in the treatment of obsessive-compulsive disorder and in treating depression that is resistant to other drugs?

Accepted Answer

A) fluoxetine (Prozac) 
B) paroxetine (Paxil) 
C) citalopram (Celexa) 
D) sertraline (Zoloft) 
A) fluoxetine (Prozac) 
B) paroxetine (Paxil) 
C) citalopram (Celexa) 
D) sertraline (Zoloft)

Question 11

Which option describes a U.S.Food and Drug Administration (FDA)safety category C drug?

Accepted Answer

A) Risk to the fetus cannot be ruled out;either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal effects or other)and there are no controlled studies or studies in women and animals are not available. 
B) There is no evidence of risk to the human fetus. 
C) Controlled studies show no risk to the fetus. 
D) There is positive evidence of risk to the fetus,but the benefits from use in pregnant women may be acceptable in certain clinical settings despite the risk. 
A) Risk to the fetus cannot be ruled out;either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal effects or other)and there are no controlled studies or studies in women and animals are not available. 
B) There is no evidence of risk to the human fetus. 
C) Controlled studies show no risk to the fetus. 
D) There is positive evidence of risk to the fetus,but the benefits from use in pregnant women may be acceptable in certain clinical settings despite the risk.

Question 12

Diazepam has a fast onset,with peak effect occurring in:

Accepted Answer

A) 30 to 60 minutes. 
B) 30 minutes to 2 hours. 
C) 1 to 2 hours. 
D) 6 hours. 
A) 30 to 60 minutes. 
B) 30 minutes to 2 hours. 
C) 1 to 2 hours. 
D) 6 hours.

Question 13

Which statement best describes the actions of gamma-aminobutyric acid (GABA)?

Accepted Answer

A) The major inhibitory neurotransmitter in the CNS 
B) A substance that binds with a CNS receptor to excite a postsynaptic neuron 
C) An unpleasant emotional state consisting of apprehension,fear,and feelings of danger 
D) A natural substance commonly used to treat anxiety 
A) The major inhibitory neurotransmitter in the CNS 
B) A substance that binds with a CNS receptor to excite a postsynaptic neuron 
C) An unpleasant emotional state consisting of apprehension,fear,and feelings of danger 
D) A natural substance commonly used to treat anxiety

Question 14

Which side effect is common to MAOIs,TCAs,and SSRIs?

Accepted Answer

A) Weight gain 
B) Arrhythmias 
C) Nausea and vomiting 
D) Polyuria 
A) Weight gain 
B) Arrhythmias 
C) Nausea and vomiting 
D) Polyuria

Question 15

Which drug is used in the treatment of depression but has also recently found favor as an agent in smoking cessation programs when combined with behavior modification?

Accepted Answer

A) sertraline (Zoloft) 
B) fluoxetine (Prozac) 
C) venlafaxine (Effexor) 
D) bupropion (Wellbutrin) 
A) sertraline (Zoloft) 
B) fluoxetine (Prozac) 
C) venlafaxine (Effexor) 
D) bupropion (Wellbutrin)

Question 16

Tardive dyskinesia is a side effect of which drug?

Accepted Answer

A) trazodone (Desyrel) 
B) chlorpromazine (Thorazine) 
C) risperidone (Risperdal) 
D) amitriptyline (Elavil) 
A) trazodone (Desyrel) 
B) chlorpromazine (Thorazine) 
C) risperidone (Risperdal) 
D) amitriptyline (Elavil)

Question 17

Which benzodiazepine is metabolized in the liver and therefore should not be used in those with liver disease?

Accepted Answer

A) lorazepam (Ativan) 
B) temazepam (Restoril) 
C) midazolam (Versed) 
D) oxazepam (Serax) 
A) lorazepam (Ativan) 
B) temazepam (Restoril) 
C) midazolam (Versed) 
D) oxazepam (Serax)

Question 18

Although many SSRIs inhibit reuptake of serotonin at CNS neurons,this agent causes more serotonin and norepinephrine to be released.

Accepted Answer

A) trazodone (Desyrel) 
B) bupropion (Wellbutrin) 
C) venlafaxine (Effexor) 
D) paroxetine (Paxil) 
A) trazodone (Desyrel) 
B) bupropion (Wellbutrin) 
C) venlafaxine (Effexor) 
D) paroxetine (Paxil)

Question 19

Which antidepressant is similar to benzodiazepines in that when it is used to treat depression,it is particularly effective for improving sleep because its side effects include drowsiness?

Accepted Answer

A) lithium (Eskalith) 
B) bupropion (Wellbutrin) 
C) trazodone (Desyrel) 
D) doxepin (Sinequan) 
A) lithium (Eskalith) 
B) bupropion (Wellbutrin) 
C) trazodone (Desyrel) 
D) doxepin (Sinequan)

Question 20

Which substance can prolong the half-life of lithium?

Accepted Answer

A) Sodium 
B) Potassium 
C) Vitamin C 
D) Calcium 
A) Sodium 
B) Potassium 
C) Vitamin C 
D) Calcium

Exam 15: Practical Pharmacotherapy of Drugs Used to Treat Psychiatric Disorders

Which medication requires complete blood count monitoring due to the increased risk of aplastic anemia?

Which drug can be used to help treat neuroleptic malignant syndrome (NMS)?

The common antidepressant fluoxetine is considered to be in what FDA safety category?

Trazodone (Desyrel)should be taken in divided doses because it can increase the concentration of which drug?

Which option best describes the mechanism of action of SSRIs?

Which drug has been used in the treatment of Tourette's syndrome?

Which drug is a tricyclic antidepressant that is preferred in the treatment of severely depressed patients who are anxious and agitated,specifically because of its sedating effect?

When starting a patient on imipramine (Tofranil),how long should it take for the antidepressant clinical effects to appear?

Which of the following drugs is used to manage both positive and negative mood symptoms of schizophrenia because of the low incidence of side effects and increased safety profile over clozapine (Clozaril)?

Which selective serotonin reuptake inhibitor (SSRI)is used in the treatment of obsessive-compulsive disorder and in treating depression that is resistant to other drugs?

Which option describes a U.S.Food and Drug Administration (FDA)safety category C drug?

Diazepam has a fast onset,with peak effect occurring in:

Which statement best describes the actions of gamma-aminobutyric acid (GABA)?

Which side effect is common to MAOIs,TCAs,and SSRIs?

Which drug is used in the treatment of depression but has also recently found favor as an agent in smoking cessation programs when combined with behavior modification?

Tardive dyskinesia is a side effect of which drug?

Which benzodiazepine is metabolized in the liver and therefore should not be used in those with liver disease?

Although many SSRIs inhibit reuptake of serotonin at CNS neurons,this agent causes more serotonin and norepinephrine to be released.

Which antidepressant is similar to benzodiazepines in that when it is used to treat depression,it is particularly effective for improving sleep because its side effects include drowsiness?

Which substance can prolong the half-life of lithium?

Conscientious and Rational Prescribing in the 21st Century

An Introduction to Pharmacodynamics and Pharmacokinetics

Communicating With Patients About Medications: a Patient-Centered Approach

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