Question 1

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once.
-NSAIDs

Accepted Answer

A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain 
A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain C

Question 2

Match the NSAID adverse reaction with the correct signs and symptoms.
-Salicylism

Accepted Answer

A) Fatigue,lethargy,pruritus,jaundice,and headache 
B) Black tarry stool,skin rash,edema,and weight gain 
C) Nausea,vomiting,and diaphoresis 
D) Headache,dizziness,tinnitus,and hearing loss 
A) Fatigue,lethargy,pruritus,jaundice,and headache 
B) Black tarry stool,skin rash,edema,and weight gain 
C) Nausea,vomiting,and diaphoresis 
D) Headache,dizziness,tinnitus,and hearing loss D

Question 3

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once.
-Tumor necrosis factor

Accepted Answer

A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain 
A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain A

Question 4

Tumor necrosis factor (TNF)was developed by recombinant DNA synthesis.By what mechanism does etanercept affect the pathology of RA?

Accepted Answer

A) Etanercept targets TNF-alpha and is specific to only the human form. 
B) Etanercept acts by blocking the action of interleukin-1. 
C) Etanercept interferes with the inflammatory cascade initiated by TNR-alpha,thereby lowering circulating cytokines. 
D) Etanercept interferes with collagen biosynthesis. 
A) Etanercept targets TNF-alpha and is specific to only the human form. 
B) Etanercept acts by blocking the action of interleukin-1. 
C) Etanercept interferes with the inflammatory cascade initiated by TNR-alpha,thereby lowering circulating cytokines. 
D) Etanercept interferes with collagen biosynthesis.

Question 5

Patient noncompliance regarding use of NSAIDs for bone and joint disorders is a significant cause of medication ineffectiveness.What is one possible explanation for this noncompliance?

Accepted Answer

A) NSAIDs often leave an unpleasant bitter aftertaste that may affect a patient's ability to properly appreciate the taste of food. 
B) Once a patient begins to take NSAIDs,it may take up to 2 weeks to see improvement in arthritis symptoms. 
C) NSAIDs often cause moderate lethargy in patients,decreasing their daily productivity. 
D) Patients who initiate a course of NSAIDs may be afraid that they will gain an excessive amount of weight due to water retention (predominantly women). 
A) NSAIDs often leave an unpleasant bitter aftertaste that may affect a patient's ability to properly appreciate the taste of food. 
B) Once a patient begins to take NSAIDs,it may take up to 2 weeks to see improvement in arthritis symptoms. 
C) NSAIDs often cause moderate lethargy in patients,decreasing their daily productivity. 
D) Patients who initiate a course of NSAIDs may be afraid that they will gain an excessive amount of weight due to water retention (predominantly women).

Question 6

Match the drug with its correct mechanism of action.
-methotrexate (Folex,Rheumatrex)

Accepted Answer

A) Decreases the T-cell response to mitogens 
B) Chimeric monoclonal antibody 
C) Alters cellular mechanisms such as collagen biosynthesis 
D) Folate antimetabolite that inhibits DNA synthesis 
E) Triggers p53 translocation,inhibiting pyrimidine 
A) Decreases the T-cell response to mitogens 
B) Chimeric monoclonal antibody 
C) Alters cellular mechanisms such as collagen biosynthesis 
D) Folate antimetabolite that inhibits DNA synthesis 
E) Triggers p53 translocation,inhibiting pyrimidine

Question 7

A 76-year-old patient has not had significant reduction in osteoarthritic shoulder pain after 8 weeks of nondrug therapy.The most symptomatic shoulder is the patient's dominant arm.She has taken acetaminophen for pain without relief.What consideration is the least significant in choosing an NSAID for her?

Accepted Answer

A) The cost of the drug 
B) Prior history of gastrointestinal intolerance to NSAIDs 
C) History of congestive heart failure 
D) History of reaction to colchicine 
E) Bleeding disorder history 
A) The cost of the drug 
B) Prior history of gastrointestinal intolerance to NSAIDs 
C) History of congestive heart failure 
D) History of reaction to colchicine 
E) Bleeding disorder history

Question 8

Match the drug with its correct mechanism of action.
-leflunomide (Arava)

Accepted Answer

A) Decreases the T-cell response to mitogens 
B) Chimeric monoclonal antibody 
C) Alters cellular mechanisms such as collagen biosynthesis 
D) Folate antimetabolite that inhibits DNA synthesis 
E) Triggers p53 translocation,inhibiting pyrimidine 
A) Decreases the T-cell response to mitogens 
B) Chimeric monoclonal antibody 
C) Alters cellular mechanisms such as collagen biosynthesis 
D) Folate antimetabolite that inhibits DNA synthesis 
E) Triggers p53 translocation,inhibiting pyrimidine

Question 9

Match the therapeutic agent with its correct mechanism of action.Mechanism of actions may be used more than once.
-colchicine

Accepted Answer

A) Enzyme xanthine oxidase inhibitor 
B) Plant alkaloid believed to interfere with leukocyte function 
C) Inhibits renal tubular absorption of uric acid 
A) Enzyme xanthine oxidase inhibitor 
B) Plant alkaloid believed to interfere with leukocyte function 
C) Inhibits renal tubular absorption of uric acid

Question 10

A 67-year-old patient is diagnosed with bilateral osteoarthritic knee pain.The patient begins to successfully lose weight and completes 6 weeks of range of motion and muscle strengthening therapy.He states during his follow-up visit that he has significantly reduced knee pain.What is the most appropriate course of management?

Accepted Answer

A) A 4-week course of acetaminophen 
B) Topical capsaicin 
C) A 6-week course of celecoxib (Celebrex) 
D) Continuation of current management 
A) A 4-week course of acetaminophen 
B) Topical capsaicin 
C) A 6-week course of celecoxib (Celebrex) 
D) Continuation of current management

Question 11

Patients taking low doses of aspirin daily are at risk for gouty attacks.What is the mechanism by which this situation may occur?

Accepted Answer

A) Aspirin interferes with uric acid secretion. 
B) Aspirin interferes with uric acid excretion. 
C) Aspirin interferes with the production of uric acid. 
D) Aspirin blocks the inflammatory cascade. 
A) Aspirin interferes with uric acid secretion. 
B) Aspirin interferes with uric acid excretion. 
C) Aspirin interferes with the production of uric acid. 
D) Aspirin blocks the inflammatory cascade.

Question 12

What unique property does aspirin possess that differs from other NSAIDs?

Accepted Answer

A) Antipyretic properties 
B) Anti-inflammatory properties 
C) Analgesic properties 
D) Antiplatelet properties 
A) Antipyretic properties 
B) Anti-inflammatory properties 
C) Analgesic properties 
D) Antiplatelet properties

Question 13

Match the drug with its correct mechanism of action.
-infliximab (Remicade)

Accepted Answer

A) Decreases the T-cell response to mitogens 
B) Chimeric monoclonal antibody 
C) Alters cellular mechanisms such as collagen biosynthesis 
D) Folate antimetabolite that inhibits DNA synthesis 
E) Triggers p53 translocation,inhibiting pyrimidine 
A) Decreases the T-cell response to mitogens 
B) Chimeric monoclonal antibody 
C) Alters cellular mechanisms such as collagen biosynthesis 
D) Folate antimetabolite that inhibits DNA synthesis 
E) Triggers p53 translocation,inhibiting pyrimidine

Question 14

What treatment of acute acetaminophen overdose is best directed at protection against hepatic damage?

Accepted Answer

A) Gastric lavage within 6 hours of ingestion 
B) Administration of high doses of steroids 
C) Administration of N-acetylcysteine within 24 hours of ingestion 
D) Forced diuresis within 12 hours of ingestion 
A) Gastric lavage within 6 hours of ingestion 
B) Administration of high doses of steroids 
C) Administration of N-acetylcysteine within 24 hours of ingestion 
D) Forced diuresis within 12 hours of ingestion

Question 15

Which agent is an example of a nonbiological disease-modifying antirheumatic drug?

Accepted Answer

A) adalimumab (Humara) 
B) etanercept (Enbrel) 
C) anakinra (Kineret) 
D) methotrexate (Folex,Rheumatrex) 
A) adalimumab (Humara) 
B) etanercept (Enbrel) 
C) anakinra (Kineret) 
D) methotrexate (Folex,Rheumatrex)

Question 16

Match the NSAID adverse reaction with the correct signs and symptoms.
-Tylenol toxicity

Accepted Answer

A) Fatigue,lethargy,pruritus,jaundice,and headache 
B) Black tarry stool,skin rash,edema,and weight gain 
C) Nausea,vomiting,and diaphoresis 
D) Headache,dizziness,tinnitus,and hearing loss 
A) Fatigue,lethargy,pruritus,jaundice,and headache 
B) Black tarry stool,skin rash,edema,and weight gain 
C) Nausea,vomiting,and diaphoresis 
D) Headache,dizziness,tinnitus,and hearing loss

Question 17

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once.
-COX

Accepted Answer

A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain 
A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain

Question 18

What advantage do COX-2 isomers possess that makes them more desirable than COX-1 isomers for the treatment of osteoarthritis?

Accepted Answer

A) COX-2 isomers are present in all cells and thus are constantly available. 
B) COX-2 isomers are released upon the initiation of inflammation. 
C) COX-2 isomers play a role in prostaglandin production. 
D) COX-2 isomers are expressed by the human kidney. 
A) COX-2 isomers are present in all cells and thus are constantly available. 
B) COX-2 isomers are released upon the initiation of inflammation. 
C) COX-2 isomers play a role in prostaglandin production. 
D) COX-2 isomers are expressed by the human kidney.

Question 19

Which of the following changes is not typically seen in a patient with RA?

Accepted Answer

A) Joint and surrounding soft tissue inflammation 
B) Synovial proliferation 
C) Cartilage erosion 
D) Bony erosion 
E) Osteoporosis 
A) Joint and surrounding soft tissue inflammation 
B) Synovial proliferation 
C) Cartilage erosion 
D) Bony erosion 
E) Osteoporosis

Question 20

Which of the following drugs used to treat gout does not affect the circulatory levels of uric acid?

Accepted Answer

A) colchicine 
B) allopurinol (Zyloprim) 
C) probenecid (Benemid) 
D) sulfinpyrazone (Anturane) 
A) colchicine 
B) allopurinol (Zyloprim) 
C) probenecid (Benemid) 
D) sulfinpyrazone (Anturane)

Exam 4: Drugs Used in the Treatment of Bone and Joint Disorders

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once. -NSAIDs

Match the NSAID adverse reaction with the correct signs and symptoms. -Salicylism

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once. -Tumor necrosis factor

Tumor necrosis factor (TNF)was developed by recombinant DNA synthesis.By what mechanism does etanercept affect the pathology of RA?

Patient noncompliance regarding use of NSAIDs for bone and joint disorders is a significant cause of medication ineffectiveness.What is one possible explanation for this noncompliance?

Match the drug with its correct mechanism of action. -methotrexate (Folex,Rheumatrex)

Match the drug with its correct mechanism of action. -leflunomide (Arava)

Match the therapeutic agent with its correct mechanism of action.Mechanism of actions may be used more than once. -colchicine

Patients taking low doses of aspirin daily are at risk for gouty attacks.What is the mechanism by which this situation may occur?

What unique property does aspirin possess that differs from other NSAIDs?

Match the drug with its correct mechanism of action. -infliximab (Remicade)

What treatment of acute acetaminophen overdose is best directed at protection against hepatic damage?

Which agent is an example of a nonbiological disease-modifying antirheumatic drug?

Match the NSAID adverse reaction with the correct signs and symptoms. -Tylenol toxicity

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once. -COX

What advantage do COX-2 isomers possess that makes them more desirable than COX-1 isomers for the treatment of osteoarthritis?

Which of the following changes is not typically seen in a patient with RA?

Which of the following drugs used to treat gout does not affect the circulatory levels of uric acid?

Conscientious and Rational Prescribing in the 21st Century

An Introduction to Pharmacodynamics and Pharmacokinetics

Communicating With Patients About Medications: a Patient-Centered Approach

Drugs Used in the Treatment of Eye and Ear Disorders

Drugs Used in the Treatment of Cardiovascular Disorders

Drugs Used to Regulate Blood Pressure

Drugs Used in the Treatment of Hyperlipidemias

Drugs Used in the Treatment of Blood Disorders

Drugs Used in the Treatment of Pulmonary Diseases and Disorders

Drugs Used in the Treatment of Common Disorders of the Gastrointestinal System

Drugs Used to Treat Endocrine Gland Disorders

Drugs Used in the Treatment of Diabetes Mellitus

Drugs Used to Treat Common Neurological Conditions

Practical Pharmacotherapy of Drugs Used to Treat Psychiatric Disorders

Drugs Used in the Treatment of Skin Disorders

Modern Approaches to Managing Bacterial Infections

Drugs Used in the Treatment of Nonbacterial Infections

Drugs Used in the Treatment of Neoplasms

Drugs Used to Affect Womens Health

Drugs Used to Affect Mens Health

Prescribing for the Geriatric Patient

Prescribing for the Pediatric Patient

Drugs Used to Manage Pain

The Integrative Medicine Pharmacopoeia: Herbals, vitamins, and Dietary Supplements

Agents Used to Manipulate the Immune Response

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