Question 1

Ketoconazole (Nizoral)is metabolized via:

Accepted Answer

A) Stomach. 
B) Liver. 
C) Spleen. 
D) Large bowel. 
A) Stomach. 
B) Liver. 
C) Spleen. 
D) Large bowel. B

Question 2

NRTIs are excreted via:

Accepted Answer

A) Skin. 
B) Liver. 
C) Feces. 
D) Urine. 
A) Skin. 
B) Liver. 
C) Feces. 
D) Urine. D

Question 3

Which drug is rapidly converted to acyclovir when administered orally?

Accepted Answer

A) valacyclovir (Valtrex) 
B) ganciclovir (Cytovene) 
C) penciclovir (Denavir) 
D) ribavirin (Virazole) 
A) valacyclovir (Valtrex) 
B) ganciclovir (Cytovene) 
C) penciclovir (Denavir) 
D) ribavirin (Virazole) A

Question 4

Which drug can be given to treat Plasmodium falciparum malaria?

Accepted Answer

A) pyrantel pamoate (Pin-Rid) 
B) quinidine gluconate 
C) indinavir (Crixivan) 
D) abacavir (Ziagen) 
A) pyrantel pamoate (Pin-Rid) 
B) quinidine gluconate 
C) indinavir (Crixivan) 
D) abacavir (Ziagen)

Question 5

Clinical studies seem to indicate that this drug shortens the duration of influenza by several days:

Accepted Answer

A) zanamivir (Relenza). 
B) indinavir (Crixivan). 
C) abacavir (Ziagen). 
D) kanamycin (Kantrex). 
A) zanamivir (Relenza). 
B) indinavir (Crixivan). 
C) abacavir (Ziagen). 
D) kanamycin (Kantrex).

Question 6

Other than lamivudine,the half-life of NRTIs is:

Accepted Answer

A) 30 minutes. 
B) 60 minutes. 
C) 90 minutes. 
D) 2 hours. 
A) 30 minutes. 
B) 60 minutes. 
C) 90 minutes. 
D) 2 hours.

Question 7

Which drug is an analog of sialic acid and is a potent selective inhibitor of influenza A and B virus neuraminidase?

Accepted Answer

A) amantadine (Symmetrel) 
B) rimantadine (Flumadine) 
C) oseltamivir (Tamiflu) 
D) zanamivir (Relenza) 
A) amantadine (Symmetrel) 
B) rimantadine (Flumadine) 
C) oseltamivir (Tamiflu) 
D) zanamivir (Relenza)

Question 8

According to the U.S.Department of Health and Human Service's April 2009 published guidelines and recommendations for antiretroviral therapy,initial treatment for HIV should include which drugs?

Accepted Answer

A) Two nucleoside analogues (NRTIs)in combination with one protease inhibitor (PI) 
B) One nucleoside analogue (NRTI)in combination with one PI 
C) Two nucleoside analogues (NRTIs)in combination with two PI s 
D) Two nucleoside analogues (NRTIs) 
A) Two nucleoside analogues (NRTIs)in combination with one protease inhibitor (PI) 
B) One nucleoside analogue (NRTI)in combination with one PI 
C) Two nucleoside analogues (NRTIs)in combination with two PI s 
D) Two nucleoside analogues (NRTIs)

Question 9

Malarone is composed of which two medications?

Accepted Answer

A) chloroquine and primaquine 
B) primaquine and proguanil 
C) atovaquone and proguanil 
D) atovaquone and chloroquine 
A) chloroquine and primaquine 
B) primaquine and proguanil 
C) atovaquone and proguanil 
D) atovaquone and chloroquine

Question 10

Which drug is used only as a topical drug to treat herpes virus?

Accepted Answer

A) acyclovir (Zovirax) 
B) penciclovir (Denavir) 
C) famciclovir (Famvir) 
D) valacyclovir (Valtrex) 
A) acyclovir (Zovirax) 
B) penciclovir (Denavir) 
C) famciclovir (Famvir) 
D) valacyclovir (Valtrex)

Question 11

Which drug is a nucleoside reverse transcriptase inhibitor (NRTI)?

Accepted Answer

A) emtricitabine (Emtriva) 
B) atazanavir (Reyataz) 
C) efavirenz (Sustiva) 
D) nevirapine (Viramune) 
A) emtricitabine (Emtriva) 
B) atazanavir (Reyataz) 
C) efavirenz (Sustiva) 
D) nevirapine (Viramune)

Question 12

Which drug interferes with the ability of a virus to synthesize its own DNA and finds great use in the treatment of recurrent genital herpes?

Accepted Answer

A) acyclovir (Zovirax) 
B) delavirdine (Rescriptor) 
C) zidovudine (Retrovir) 
D) ribavirin (Virazole) 
A) acyclovir (Zovirax) 
B) delavirdine (Rescriptor) 
C) zidovudine (Retrovir) 
D) ribavirin (Virazole)

Question 13

The NRTI didanosine (Videx)can cause which adverse reaction?

Accepted Answer

A) Anemia 
B) Leukopenia 
C) Pancreatitis 
D) Hepatosplenomegaly 
A) Anemia 
B) Leukopenia 
C) Pancreatitis 
D) Hepatosplenomegaly

Question 14

What is the mechanism of action of nitazoxanide (Alinia)?

Accepted Answer

A) Interferes with the pyruvate ferredoxin enzyme pathway,which is essential for energy metabolism in anaerobic bacteria 
B) Binds to microtubules comprising the spindles and inhibits fungal mitosis 
C) Inhibits squalene 2,3-epoxidase,making it fungicidal to sensitive organisms 
D) Inhibits formation of the fungus microtubules,which in turn irreversibly blocks uptake of glucose so the fungi stop replicating 
A) Interferes with the pyruvate ferredoxin enzyme pathway,which is essential for energy metabolism in anaerobic bacteria 
B) Binds to microtubules comprising the spindles and inhibits fungal mitosis 
C) Inhibits squalene 2,3-epoxidase,making it fungicidal to sensitive organisms 
D) Inhibits formation of the fungus microtubules,which in turn irreversibly blocks uptake of glucose so the fungi stop replicating

Question 15

Which drug binds to sterols in the fungal cell membrane (ergosterol),altering the membrane's permeability to potassium,magnesium,and other components of the cell?

Accepted Answer

A) miconazole (Monistat) 
B) nystatin (Mycostatin) 
C) terbinafine (Lamisil) 
D) flucytosine (Ancobon) 
A) miconazole (Monistat) 
B) nystatin (Mycostatin) 
C) terbinafine (Lamisil) 
D) flucytosine (Ancobon)

Question 16

Which drug is inhibitory for all herpes viruses but is best reserved for cytomegalovirus (CMV)?

Accepted Answer

A) acyclovir (Zovirax) 
B) famciclovir (Famvir) 
C) ganciclovir (Cytovene) 
D) penciclovir (Denavir) 
A) acyclovir (Zovirax) 
B) famciclovir (Famvir) 
C) ganciclovir (Cytovene) 
D) penciclovir (Denavir)

Question 17

Which drug is an antiviral that can be used to treat herpes simplex virus?

Accepted Answer

A) zanamivir (Relenza) 
B) famciclovir (Famvir) 
C) amphotericin B (Fungizone) 
D) mebendazole (Vermox) 
A) zanamivir (Relenza) 
B) famciclovir (Famvir) 
C) amphotericin B (Fungizone) 
D) mebendazole (Vermox)

Question 18

Which antiparasitic drug is related to the macrolide antibiotics?

Accepted Answer

A) ivermectin (Eqvalan,Ivomec) 
B) pyrantel pamoate (Pin-Rid) 
C) metronidazole (Flagyl,Protostat) 
D) primaquine (Malaride) 
A) ivermectin (Eqvalan,Ivomec) 
B) pyrantel pamoate (Pin-Rid) 
C) metronidazole (Flagyl,Protostat) 
D) primaquine (Malaride)

Question 19

PIs are metabolized via:

Accepted Answer

A) Small bowel. 
B) Large bowel. 
C) Liver. 
D) Kidneys. 
A) Small bowel. 
B) Large bowel. 
C) Liver. 
D) Kidneys.

Question 20

Metronidazole (Flagyl,Protostat)should not be taken with which substance?

Accepted Answer

A) alcohol 
B) acetaminophen 
C) aspirin 
D) ampicillin 
A) alcohol 
B) acetaminophen 
C) aspirin 
D) ampicillin

Exam 18: Drugs Used in the Treatment of Nonbacterial Infections

Ketoconazole (Nizoral)is metabolized via:

NRTIs are excreted via:

Which drug is rapidly converted to acyclovir when administered orally?

Which drug can be given to treat Plasmodium falciparum malaria?

Clinical studies seem to indicate that this drug shortens the duration of influenza by several days:

Other than lamivudine,the half-life of NRTIs is:

Which drug is an analog of sialic acid and is a potent selective inhibitor of influenza A and B virus neuraminidase?

According to the U.S.Department of Health and Human Service's April 2009 published guidelines and recommendations for antiretroviral therapy,initial treatment for HIV should include which drugs?

Malarone is composed of which two medications?

Which drug is used only as a topical drug to treat herpes virus?

Which drug is a nucleoside reverse transcriptase inhibitor (NRTI)?

Which drug interferes with the ability of a virus to synthesize its own DNA and finds great use in the treatment of recurrent genital herpes?

The NRTI didanosine (Videx)can cause which adverse reaction?

What is the mechanism of action of nitazoxanide (Alinia)?

Which drug binds to sterols in the fungal cell membrane (ergosterol),altering the membrane's permeability to potassium,magnesium,and other components of the cell?

Which drug is inhibitory for all herpes viruses but is best reserved for cytomegalovirus (CMV)?

Which drug is an antiviral that can be used to treat herpes simplex virus?

Which antiparasitic drug is related to the macrolide antibiotics?

PIs are metabolized via:

Metronidazole (Flagyl,Protostat)should not be taken with which substance?

Conscientious and Rational Prescribing in the 21st Century

An Introduction to Pharmacodynamics and Pharmacokinetics

Communicating With Patients About Medications: a Patient-Centered Approach

Drugs Used in the Treatment of Bone and Joint Disorders

Drugs Used in the Treatment of Eye and Ear Disorders

Drugs Used in the Treatment of Cardiovascular Disorders

Drugs Used to Regulate Blood Pressure

Drugs Used in the Treatment of Hyperlipidemias

Drugs Used in the Treatment of Blood Disorders

Drugs Used in the Treatment of Pulmonary Diseases and Disorders

Drugs Used in the Treatment of Common Disorders of the Gastrointestinal System

Drugs Used to Treat Endocrine Gland Disorders

Drugs Used in the Treatment of Diabetes Mellitus

Drugs Used to Treat Common Neurological Conditions

Practical Pharmacotherapy of Drugs Used to Treat Psychiatric Disorders

Drugs Used in the Treatment of Skin Disorders

Modern Approaches to Managing Bacterial Infections

Drugs Used in the Treatment of Neoplasms

Drugs Used to Affect Womens Health

Drugs Used to Affect Mens Health

Prescribing for the Geriatric Patient

Prescribing for the Pediatric Patient

Drugs Used to Manage Pain

The Integrative Medicine Pharmacopoeia: Herbals, vitamins, and Dietary Supplements

Agents Used to Manipulate the Immune Response

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