Exam 12: The Eukaryotic Chromosome

In a typical human cell, DNA polymerase synthesizes DNA at a rate of approximately 50 nucleotides per second.Human chromosome 1 contains about 250 million base pairs.If a single origin of replication were used, how long would it take the cell to copy this chromosome?

The total compaction of DNA as seen in metaphase chromosomes is approximately ________-fold.

Cohesins are multisubunit protein complexes that

A barrier element between a gene and heterochromatin would prevent that gene from being transcriptionally silenced by heterochromatin spreading.

The 10,000 origins of replication in mammalian cells suggests that there is

When a chromosomal rearrangement, such as an inversion, places a known gene into or next to a heterochromatic region, the gene's transcription

In higher eukaryotes, kinetochores attach to

Suppose a cell lacks functional Shugoshin.What is the predicted effect on cohesin?

During DNA replication in a typical human cell,

Which of the following is a predicted consequence of kinetochores not achieving the correct level of tension from the mitotic spindle?

Telomeres have at least two roles in chromosome integrity.Telomeres are composed of repeat sequences homologous to the RNA in telomerase used to replicate chromosome ends.Second, they

The two chromatids of each replicated chromosome must separate from one another and segregate during

One of the functions of a centromere is to form kinetochores for proper chromosome segregation.The other function is to

The first level of compaction of DNA consists of

During mitosis, kinetochores develop during

In DNA, most satellite sequences are found in

Kinetochores include motor proteins that exert pulling forces on spindle microtubules.

During development, an XX female embryo will form one of the X chromosomes in each cell into a Barr body.This usually occurs

In which of the following cases will a Barr body be seen?

Yeast research with autonomously replicating sequences (ARS), along with digestion of chromatin with DNase I, have led scientists to determine that