Question 1

Genome assembly,especially in eukaryotes,is complicated by ______________.

Accepted Answer

A)  UTRs 
B)  promoter regions 
C)  sequence tagged sites 
D)  repetitive sequences 
E)  coding sequences 
A)  UTRs 
B)  promoter regions 
C)  sequence tagged sites 
D)  repetitive sequences 
E)  coding sequences

Question 2

In the future,genomics will allow medicine to become more reactive,rather than predictive.

Accepted Answer

A) True 
 B)False

Question 3

In the context of human genome sequencing,which of the following terms is associated with the approach used by Celera,but is not associated with the publicly funded project?

Accepted Answer

A)  shotgun 
B)  karyotype 
C)  physical map 
D)  paired-end 
E)  plasmid 
A)  shotgun 
B)  karyotype 
C)  physical map 
D)  paired-end 
E)  plasmid

Question 4

A RefSeq contains

Accepted Answer

A)  a gene from the human genome,which must be a reference to assemblies in other species. 
B)  the consensus sequence for a given gene derived from sequence from all available species. 
C)  an arbitrary,but well-characterized,example genome for a species. 
D)  a genome that has been sequenced at least twice to eliminate errors. 
E)  a genome that has been sequenced to a minimum of 99% accuracy. 
A)  a gene from the human genome,which must be a reference to assemblies in other species. 
B)  the consensus sequence for a given gene derived from sequence from all available species. 
C)  an arbitrary,but well-characterized,example genome for a species. 
D)  a genome that has been sequenced at least twice to eliminate errors. 
E)  a genome that has been sequenced to a minimum of 99% accuracy.

Question 5

How do the outcomes of the human genome project and next-generation sequencing technology facilitate the transformation to "predictive,preventive,and personalized" medicine?

Accepted Answer

Low-cost,fast,simple sequencing will all

Question 6

The amount of DNA sequence in public databases doubles approximately every _____________.

Accepted Answer

A)  month 
B)  1.5 years 
C)  3 years 
D)  5 years 
E)  10 years 
A)  month 
B)  1.5 years 
C)  3 years 
D)  5 years 
E)  10 years

Question 7

An STS (sequence tagged site)is a sequence found at least twice in a given genome.

Accepted Answer

A) True 
 B)False

Question 8

An assembly of the human genome would ideally consist of

Accepted Answer

A)  23 contigs 
B)  no repetitive DNA 
C)  as many contigs as possible 
D)  >1,000 contigs 
E)  no contigs 
A)  23 contigs 
B)  no repetitive DNA 
C)  as many contigs as possible 
D)  >1,000 contigs 
E)  no contigs

Question 9

Homologous chromosomes in humans are usually 99.9 identical.

Accepted Answer

A) True 
 B)False

Question 10

Many ethicists support germline therapy but oppose somatic therapy.

Accepted Answer

A) True 
 B)False

Question 11

Which of the following is not a question examiners consider when evaluating patentability of a product or process?

Accepted Answer

A)  Is it non-obvious? 
B)  Is it useful? 
C)  Is it new? 
D)  Is it fully described (i.e.disclosed)? 
E)  Is it safe? 
A)  Is it non-obvious? 
B)  Is it useful? 
C)  Is it new? 
D)  Is it fully described (i.e.disclosed)? 
E)  Is it safe?

Question 12

Genomics is the branch of biology that

Accepted Answer

A)  studies genes. 
B)  develops and applies mapping,sequencing,and computational tools to genomes. 
C)  studies model organisms. 
D)  studies Mendelian inheritance patterns. 
E)  studies evolutionary relationships. 
A)  studies genes. 
B)  develops and applies mapping,sequencing,and computational tools to genomes. 
C)  studies model organisms. 
D)  studies Mendelian inheritance patterns. 
E)  studies evolutionary relationships.

Question 13

The Human Genome Project began in ________ and was projected to require ________ years to complete.

Accepted Answer

A)  1985;5 
B)  1985;10 
C)  1990;5 
D)  1990;15 
E)  1980;25 
A)  1985;5 
B)  1985;10 
C)  1990;5 
D)  1990;15 
E)  1980;25

Question 14

Most human polymorphisms are associated with disease.

Accepted Answer

A) True 
 B)False

Question 15

Both Sanger and pyrosequencing depend on labeled dNTPs.

Accepted Answer

A) True 
 B)False

Question 16

Which of the following is required in both pyrosequencing and Sanger sequencing?

Accepted Answer

A)  emulsion PCR 
B)  coated beads 
C)  DNA polymerase 
D)  luciferase 
E)  adapter sequences 
A)  emulsion PCR 
B)  coated beads 
C)  DNA polymerase 
D)  luciferase 
E)  adapter sequences

Question 17

Whole genome sequence assemblies are now available for more than 10000 vertebrate species.

Accepted Answer

A) True 
 B)False

Question 18

What are some situations in which it would be better to use Sanger sequencing than pyrosequencing?

Accepted Answer

Pyrosequencing (and other next-generatio

Question 19

DNA is randomly sheared during whole genome shotgun sequencing.

Accepted Answer

A) True 
 B)False

Question 20

Why do governments grant patents?

Accepted Answer

A)  To ensure public safety. 
B)  To allow companies to guard secrets. 
C)  To provide government revenue. 
D)  To provide incentive for sharing information. 
E)  To guide industrial priorities. 
A)  To ensure public safety. 
B)  To allow companies to guard secrets. 
C)  To provide government revenue. 
D)  To provide incentive for sharing information. 
E)  To guide industrial priorities.

Exam 18: The Genetic Analysis of Development

Genome assembly,especially in eukaryotes,is complicated by ______________.

In the future,genomics will allow medicine to become more reactive,rather than predictive.

In the context of human genome sequencing,which of the following terms is associated with the approach used by Celera,but is not associated with the publicly funded project?

A RefSeq contains

How do the outcomes of the human genome project and next-generation sequencing technology facilitate the transformation to "predictive,preventive,and personalized" medicine?

The amount of DNA sequence in public databases doubles approximately every _____________.

An STS (sequence tagged site)is a sequence found at least twice in a given genome.

An assembly of the human genome would ideally consist of

Homologous chromosomes in humans are usually 99.9 identical.

Many ethicists support germline therapy but oppose somatic therapy.

Which of the following is not a question examiners consider when evaluating patentability of a product or process?

Genomics is the branch of biology that

The Human Genome Project began in ________ and was projected to require ________ years to complete.

Most human polymorphisms are associated with disease.

Both Sanger and pyrosequencing depend on labeled dNTPs.

Which of the following is required in both pyrosequencing and Sanger sequencing?

Whole genome sequence assemblies are now available for more than 10000 vertebrate species.

What are some situations in which it would be better to use Sanger sequencing than pyrosequencing?

DNA is randomly sheared during whole genome shotgun sequencing.

Why do governments grant patents?

Mendels Principles of Heredity

Extensions to Mendels Laws

The Chromosome Theory of Inheritance

Linkage, Recombination, and the Mapping of Genes on Chromosomes

Dna Structure, Replication, and Recombination

Anatomy and Function of a Gene: Dissection Through Mutation

Gene Expression: the Flow of Information From Dna to Rna to Protein

Digital Analysis of Genomes

Genome Annotation

Analyzing Genomic Variation

The Eukaryotic Chromosome

Chromosomal Rearrangements and Changes in Chromosome Number

Bacterial Genetics

Organellar Inheritance

Gene Regulation in Prokaryotes

Gene Regulation in Eukaryotes

Manipulating the Genomes of Eukaryotes

The Genetics of Cancer

Variation and Selection in Populations

Genetics of Complex Traits

Exploring Synthetic Biology: Concepts, Techniques, and Applications

Filters

The Human Genome Project began in and was projected to require years to complete.