Question 1

Pattern recognition examines a string of nucleotides for sections that match a specific sequence parameter.

Accepted Answer

A) True 
 B)False  False

Question 2

A bioinformatics researcher who is looking for RFLP sites for a specific restriction enzyme would use which of the following while analyzing a section of DNA?

Accepted Answer

A)  Pattern recognition 
B)  Sequence recognition 
C)  Both of the above 
D)  Neither of the above 
A)  Pattern recognition 
B)  Sequence recognition 
C)  Both of the above 
D)  Neither of the above B

Question 3

In two dimensional gel electrophoresis, proteins are first treated with SDS and separated according to
molecular weight, and then they are separated by net charge at a specific pH.

Accepted Answer

A) True 
 B)False  False

Question 4

Expressed sequence tag libraries are also known as .

Accepted Answer

A)  RFLP libraries 
B)  cDNA libraries 
C)  YACs 
D)  Heteroduplexes 
E)  None of the answers are correct 
A)  RFLP libraries 
B)  cDNA libraries 
C)  YACs 
D)  Heteroduplexes 
E)  None of the answers are correct

Question 5

Gene chips are being used for which of the following purposes?

Accepted Answer

A)  To examine patterns of gene expression under various environmental conditions 
B)  To establish levels of genetic variation 
C)  To determine gene expression specific to certain cell types 
D)  To identify species of bacteria 
E)  All of the answers are possible 
A)  To examine patterns of gene expression under various environmental conditions 
B)  To establish levels of genetic variation 
C)  To determine gene expression specific to certain cell types 
D)  To identify species of bacteria 
E)  All of the answers are possible

Question 6

In a two-dimensional gel electrophoresis experiment, proteins are separated vertically by .

Accepted Answer

A)  Net charge 
B)  Molecular weight 
C)  Abundance 
D)  None of the answers are correct 
A)  Net charge 
B)  Molecular weight 
C)  Abundance 
D)  None of the answers are correct

Question 7

A collection of computer data files is called a database.

Accepted Answer

A) True 
 B)False

Question 8

are computational procedures that computers follow to analyze a genetic sequence.

Accepted Answer

A)  paralogs 
B)  homology-based modeling 
C)  Algorithms 
D)  E-values 
A)  paralogs 
B)  homology-based modeling 
C)  Algorithms 
D)  E-values

Question 9

A bioinformatics researcher who is looking microsatellites in a section of DNA would use which of the following?

Accepted Answer

A)  Pattern recognition 
B)  Sequence recognition 
C)  Both of the above 
D)  Neither of the above 
A)  Pattern recognition 
B)  Sequence recognition 
C)  Both of the above 
D)  Neither of the above

Question 10

BLAST stands for basic local alignment search tool.

Accepted Answer

A) True 
 B)False

Question 11

A small glass chip that contains thousands of microscopic pieces of DNA is called a DNA microarray.

Accepted Answer

A) True 
 B)False

Question 12

The degree of similarity between two genetic sequences can be determined by .

Accepted Answer

A)  Dot matrices 
B)  Multiple sequence alignments 
C)  Computer programs such as BLAST 
D)  All of the answers are correct 
A)  Dot matrices 
B)  Multiple sequence alignments 
C)  Computer programs such as BLAST 
D)  All of the answers are correct

Question 13

Bioinformatics use computer programs called to analyze data obtained from experimental procedures.

Accepted Answer

A)  Bugs 
B)  Viruses 
C)  Algorithms 
D)  Databases 
E)  None of the answers are correct 
A)  Bugs 
B)  Viruses 
C)  Algorithms 
D)  Databases 
E)  None of the answers are correct

Question 14

Homology between which of the following is the easiest to identify?

Accepted Answer

A)  Protein sequences 
B)  DNA sequences 
C)  Both are approximately equal 
A)  Protein sequences 
B)  DNA sequences 
C)  Both are approximately equal

Question 15

The three-dimensional structure of macromolecules may be determined by which of the following?

Accepted Answer

A)  Computer programs use the linear sequence to predict three-dimensional structure 
B)  Nuclear magnetic resonance 
C)  X-ray crystallography 
D)  All of the answers are correct 
A)  Computer programs use the linear sequence to predict three-dimensional structure 
B)  Nuclear magnetic resonance 
C)  X-ray crystallography 
D)  All of the answers are correct

Question 16

In a given organism, which of the following is larger?

Accepted Answer

A)  The proteome 
B)  The genome 
C)  Both are approximately the same size 
A)  The proteome 
B)  The genome 
C)  Both are approximately the same size

Question 17

Which of the following increases the size of the proteome in relation to the genome?

Accepted Answer

A)  Alternative splicing 
B)  Posttranslational covalent modification 
C)  RNA editing 
D)  All of the answers are correct 
A)  Alternative splicing 
B)  Posttranslational covalent modification 
C)  RNA editing 
D)  All of the answers are correct

Question 18

Protein microarrays may be used for which of the following?

Accepted Answer

A)  To study protein-protein interactions 
B)  To study drug-protein interactions 
C)  To determine levels of protein expression 
D)  To establish the function of a protein 
E)  All of the answers are correct 
A)  To study protein-protein interactions 
B)  To study drug-protein interactions 
C)  To determine levels of protein expression 
D)  To establish the function of a protein 
E)  All of the answers are correct

Question 19

make it possible for researchers to study how an entire genome responds to an environmental stimuli.

Accepted Answer

A)  Bioinformatics 
B)  PCR reactions 
C)  DNA microarrays 
D)  Subtractive DNA libraries 
A)  Bioinformatics 
B)  PCR reactions 
C)  DNA microarrays 
D)  Subtractive DNA libraries

Question 20

The genes of a gene family that consist of two or more homologous genes are called .

Accepted Answer

A)  Orthologs 
B)  Paralogs 
C)  Polylogs 
D)  Homologs 
A)  Orthologs 
B)  Paralogs 
C)  Polylogs 
D)  Homologs

Exam 21: Genomics II: Functional Genomics, Proteomics, and

Pattern recognition examines a string of nucleotides for sections that match a specific sequence parameter.

A bioinformatics researcher who is looking for RFLP sites for a specific restriction enzyme would use which of the following while analyzing a section of DNA?

In two dimensional gel electrophoresis, proteins are first treated with SDS and separated according to molecular weight, and then they are separated by net charge at a specific pH.

Expressed sequence tag libraries are also known as .

Gene chips are being used for which of the following purposes?

In a two-dimensional gel electrophoresis experiment, proteins are separated vertically by .

A collection of computer data files is called a database.

are computational procedures that computers follow to analyze a genetic sequence.

A bioinformatics researcher who is looking microsatellites in a section of DNA would use which of the following?

BLAST stands for basic local alignment search tool.

A small glass chip that contains thousands of microscopic pieces of DNA is called a DNA microarray.

The degree of similarity between two genetic sequences can be determined by .

Bioinformatics use computer programs called to analyze data obtained from experimental procedures.

Homology between which of the following is the easiest to identify?

The three-dimensional structure of macromolecules may be determined by which of the following?

In a given organism, which of the following is larger?

Which of the following increases the size of the proteome in relation to the genome?

Protein microarrays may be used for which of the following?

make it possible for researchers to study how an entire genome responds to an environmental stimuli.

The genes of a gene family that consist of two or more homologous genes are called .

Overview of Genetics

Mendelian Inheritance

Reproduction and Chromosome Transmission

Extensions of Mendelian Inheritance

Non-Mendelian Inheritance

Genetic Linkage and Mapping in Eukaryotes

Genetic Transfer and Mapping in Bacteria and

Variation in Chromosome Structure and Number

Molecular Structure of Dna and Rna

Chromosome Organization and Molecular Structure

Dna Replication

Gene Transcription and Rna Modification

Translation of Mrna

Gene Regulation in Bacteria and Bacteriophages

Gene Regulation in Eukaryotes

Gene Mutation and Dna Repair

Recombination and Transposition at the Molecular

Recombinant Dna Technology

Biotechnology

Genomics I: Analysis of Dna

Medical Genetics and Cancer

Developmental Genetics

Population Genetics

Quantitative Genetics

Evolutionary Genetics

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