Question 1

Most TRNE repeats involve expansion of which of the following?

Accepted Answer

A)  GAA 
B)  CAG 
C)  ATG 
D)  CCC 
E)  Any codon containing three of the same bases 
A)  GAA 
B)  CAG 
C)  ATG 
D)  CCC 
E)  Any codon containing three of the same bases B

Question 2

Mutations that change the configuration of a protein at a specific temperature are called mutations.

Accepted Answer

A)  Neutral 
B)  Beneficial 
C)  Deleterious 
D)  Conditional 
E)  None of the answers are correct 
A)  Neutral 
B)  Beneficial 
C)  Deleterious 
D)  Conditional 
E)  None of the answers are correct D

Question 3

Uses enzymes called the DNA-N-glycolases.

Accepted Answer

A)  Recombinational repair 
B)  Direct repair 
C)  Base excision repair 
D)  Mismatch repair 
E)  Nucleotide excision repair
F) Nonhomologous end joining (NHEJ) 
A)  Recombinational repair 
B)  Direct repair 
C)  Base excision repair 
D)  Mismatch repair 
E)  Nucleotide excision repair
F) Nonhomologous end joining (NHEJ) C

Question 4

The complete loss of either a guanine or adenine from DNA is an example of .

Accepted Answer

A)  Depurination 
B)  Tautomeric shifts 
C)  Deamination 
D)  None of the answers are correct 
A)  Depurination 
B)  Tautomeric shifts 
C)  Deamination 
D)  None of the answers are correct

Question 5

Which of the following integrate into the double-helix of DNA, inhibiting DNA replication?

Accepted Answer

A)  EMS 
B)  Nitrous acid 
C)  5BU 
D)  2-amino purine 
E)  Acridine dyes 
A)  EMS 
B)  Nitrous acid 
C)  5BU 
D)  2-amino purine 
E)  Acridine dyes

Question 6

Which of the following is not an example of a spontaneous mutation?

Accepted Answer

A)  DNA replication errors 
B)  Tautomeric shifts 
C)  Aberrant recombination 
D)  UV light 
E)  Transposable elements 
A)  DNA replication errors 
B)  Tautomeric shifts 
C)  Aberrant recombination 
D)  UV light 
E)  Transposable elements

Question 7

The first environmental agent shown to induce mutation was .

Accepted Answer

A)  UV radiation 
B)  Heavy metals 
C)  X-rays 
D)  Gamma rays 
E)  Uranium 
A)  UV radiation 
B)  Heavy metals 
C)  X-rays 
D)  Gamma rays 
E)  Uranium

Question 8

Which of the following are examples of suppressor mutations?

Accepted Answer

A)  An intragenic mutation that restores protein structure 
B)  An intergenic mutation that increases the activity of a protein performing the same function as the mutated protein 
C)  An intergenic mutation that activates a transcription factor that dramatically upregulates expression of the mutant protein 
D)  All of the answers are correct 
A)  An intragenic mutation that restores protein structure 
B)  An intergenic mutation that increases the activity of a protein performing the same function as the mutated protein 
C)  An intergenic mutation that activates a transcription factor that dramatically upregulates expression of the mutant protein 
D)  All of the answers are correct

Question 9

Ethyl methanesulfonate (EMS) is an example of a deaminating agent.

Accepted Answer

A) True 
 B)False

Question 10

Is responsible for repairing damage from UV radiation.

Accepted Answer

A)  Recombinational repair 
B)  Direct repair 
C)  Base excision repair 
D)  Mismatch repair 
E)  Nucleotide excision repair
F) Nonhomologous end joining (NHEJ) 
A)  Recombinational repair 
B)  Direct repair 
C)  Base excision repair 
D)  Mismatch repair 
E)  Nucleotide excision repair
F) Nonhomologous end joining (NHEJ)

Question 11

Anticipation is associated with which of the following?

Accepted Answer

A)  Nonsense mutations 
B)  Up-promoter mutations 
C)  Intergenic suppressors 
D)  TRNE mutations 
E)  None of the answers are correct 
A)  Nonsense mutations 
B)  Up-promoter mutations 
C)  Intergenic suppressors 
D)  TRNE mutations 
E)  None of the answers are correct

Question 12

A mutation in a gene that restore the wild-type phenotype of a second gene is called a suppressor
mutation.

Accepted Answer

A) True 
 B)False

Question 13

Photolyase in yeast.

Accepted Answer

A)  Recombinational repair 
B)  Direct repair 
C)  Base excision repair 
D)  Mismatch repair 
E)  Nucleotide excision repair
F) Nonhomologous end joining (NHEJ) 
A)  Recombinational repair 
B)  Direct repair 
C)  Base excision repair 
D)  Mismatch repair 
E)  Nucleotide excision repair
F) Nonhomologous end joining (NHEJ)

Question 14

The process of replica plating is designed to test if advantageous mutations result in response to the
selective agent or were naturally present in the population before selection.

Accepted Answer

A) True 
 B)False

Question 15

Which of the following is correct regarding the rate of mutation?

Accepted Answer

A)  Rates of mutation per cell generation typically range from 10-5 to 10-9 
B)  Mutation rates are consistent across species 
C)  Mutation rates are not influenced by environmental conditions 
D)  Mutation rates are constant 
E)  All of the answers are correct 
A)  Rates of mutation per cell generation typically range from 10-5 to 10-9 
B)  Mutation rates are consistent across species 
C)  Mutation rates are not influenced by environmental conditions 
D)  Mutation rates are constant 
E)  All of the answers are correct

Question 16

A change in the chromosome number is called a point mutation.

Accepted Answer

A) True 
 B)False

Question 17

Often leads to deletion in chromosome sequence.

Accepted Answer

A)  Recombinational repair 
B)  Direct repair 
C)  Base excision repair 
D)  Mismatch repair 
E)  Nucleotide excision repair
F) Nonhomologous end joining (NHEJ) 
A)  Recombinational repair 
B)  Direct repair 
C)  Base excision repair 
D)  Mismatch repair 
E)  Nucleotide excision repair
F) Nonhomologous end joining (NHEJ)

Question 18

Somatic cells are those that give rise to sperm and egg cells.

Accepted Answer

A) True 
 B)False

Question 19

After screening a colony of bacteria for a given gene, you discover 100 mutant colonies out of 3 million total colonies. What is the mutation frequency for this gene in the population?

Accepted Answer

A)  1.0 x 105 
B)  1.0 x 10-5 
C)  3.0 x 105 
D)  3.3 x 10-5 
E)  None of the answers are correct 
A)  1.0 x 105 
B)  1.0 x 10-5 
C)  3.0 x 105 
D)  3.3 x 10-5 
E)  None of the answers are correct

Question 20

The conversion of cytosine to uracil in DNA is an example of .

Accepted Answer

A)  Depurination 
B)  Tautomeric shifts 
C)  Deamination 
D)  None of the answers are correct 
A)  Depurination 
B)  Tautomeric shifts 
C)  Deamination 
D)  None of the answers are correct

Exam 16: Gene Mutation and Dna Repair

Most TRNE repeats involve expansion of which of the following?

Mutations that change the configuration of a protein at a specific temperature are called mutations.

Uses enzymes called the DNA-N-glycolases.

The complete loss of either a guanine or adenine from DNA is an example of .

Which of the following integrate into the double-helix of DNA, inhibiting DNA replication?

Which of the following is not an example of a spontaneous mutation?

The first environmental agent shown to induce mutation was .

Which of the following are examples of suppressor mutations?

Ethyl methanesulfonate (EMS) is an example of a deaminating agent.

Is responsible for repairing damage from UV radiation.

Anticipation is associated with which of the following?

A mutation in a gene that restore the wild-type phenotype of a second gene is called a suppressor mutation.

Photolyase in yeast.

The process of replica plating is designed to test if advantageous mutations result in response to the selective agent or were naturally present in the population before selection.

Which of the following is correct regarding the rate of mutation?

A change in the chromosome number is called a point mutation.

Often leads to deletion in chromosome sequence.

Somatic cells are those that give rise to sperm and egg cells.

After screening a colony of bacteria for a given gene, you discover 100 mutant colonies out of 3 million total colonies. What is the mutation frequency for this gene in the population?

The conversion of cytosine to uracil in DNA is an example of .

Overview of Genetics

Mendelian Inheritance

Reproduction and Chromosome Transmission

Extensions of Mendelian Inheritance

Non-Mendelian Inheritance

Genetic Linkage and Mapping in Eukaryotes

Genetic Transfer and Mapping in Bacteria and

Variation in Chromosome Structure and Number

Molecular Structure of Dna and Rna

Chromosome Organization and Molecular Structure

Dna Replication

Gene Transcription and Rna Modification

Translation of Mrna

Gene Regulation in Bacteria and Bacteriophages

Gene Regulation in Eukaryotes

Recombination and Transposition at the Molecular

Recombinant Dna Technology

Biotechnology

Genomics I: Analysis of Dna

Genomics II: Functional Genomics, Proteomics, and

Medical Genetics and Cancer

Developmental Genetics

Population Genetics

Quantitative Genetics

Evolutionary Genetics

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