Question 1

What region in eukaryotic genes contains the majority of regulatory elements?

Accepted Answer

A)  0 to 50 
B)  -50 to 0 
C)  -50 to -100 
D)  -100 to -150 
A)  0 to 50 
B)  -50 to 0 
C)  -50 to -100 
D)  -100 to -150

Question 2

In eukaryotic organisms, the processing of the 45S rRNA into 5.8S, 18S, and 28S rRNA occurs where?

Accepted Answer

A)  In the cytoplasm 
B)  In the nucleolus 
C)  In the endoplasmic reticulum 
D)  In the Golgi body 
E)  Throughout the cell 
A)  In the cytoplasm 
B)  In the nucleolus 
C)  In the endoplasmic reticulum 
D)  In the Golgi body 
E)  Throughout the cell

Question 3

What structural motif is most commonly used by transcription factors in binding to DNA?

Accepted Answer

A)  Zinc-finger 
B)  Helix-turn-helix 
C)  Leucine zipper 
D)  Homeodomain 
A)  Zinc-finger 
B)  Helix-turn-helix 
C)  Leucine zipper 
D)  Homeodomain

Question 4

What do both the rho-dependent and rho-independent mechanisms of termination have in common?

Accepted Answer

A)  Terminate transcription immediately after the stop codon 
B)  A sequence rich with A-U base pairs 
C)  Both require a helicase to separate the DNA-RNA complex 
D)  Formation of a stem-loop structure 
A)  Terminate transcription immediately after the stop codon 
B)  A sequence rich with A-U base pairs 
C)  Both require a helicase to separate the DNA-RNA complex 
D)  Formation of a stem-loop structure

Question 5

Which of the following provides for a higher level of stability in the mRNA?

Accepted Answer

A)  Alternative splicing 
B)  RNA editing 
C)  5' capping 
D)  3' polyA tailing 
E)  Trimming 
A)  Alternative splicing 
B)  RNA editing 
C)  5' capping 
D)  3' polyA tailing 
E)  Trimming

Question 6

Which of the following forms of RNA encodes the sequence of amino acids for a functional protein?

Accepted Answer

A)  tRNA 
B)  snRNA 
C)  mRNA 
D)  rRNA 
E)  scRNA 
A)  tRNA 
B)  snRNA 
C)  mRNA 
D)  rRNA 
E)  scRNA

Question 7

What amino acid is the target of histone acetyltransferases?

Accepted Answer

A)  Arginine 
B)  Lysine 
C)  Methionine 
D)  Histidine 
A)  Arginine 
B)  Lysine 
C)  Methionine 
D)  Histidine

Question 8

Which of the following is the site for the start of transcription?

Accepted Answer

A)  Promoter 
B)  Terminator 
C)  Regulation sequences 
D)  Transcription factors 
E)  All of the answers may start transcription 
A)  Promoter 
B)  Terminator 
C)  Regulation sequences 
D)  Transcription factors 
E)  All of the answers may start transcription

Question 9

The consensus sequences are 5'TTGACA3' and 5'TATAAT3' at -35 and -10 respectively. Which of the following would be most easily recognized by σ factor?

Accepted Answer

A)  5'TTGAAA3' 
B)  5'TAAATT3' 
C)  5'TATATA3' 
D)  5'TTCAGA3' 
A)  5'TTGAAA3' 
B)  5'TAAATT3' 
C)  5'TATATA3' 
D)  5'TTCAGA3'

Question 10

What transcripts are made by RNA polymerase I in eukaryotes?

Accepted Answer

A)  snRNA 
B)  tRNA 
C)  5S rRNA 
D)  18S rRNA 
A)  snRNA 
B)  tRNA 
C)  5S rRNA 
D)  18S rRNA

Question 11

The formation of open complex usually forms in GC rich regions of DNA due to the decreased
number of hydrogen bonds.

Accepted Answer

A) True 
 B)False

Question 12

Sigma factor belongs to a general group of proteins called the transcription factors.

Accepted Answer

A) True 
 B)False

Question 13

The process of RNA editing can alter the base sequence of the mRNA following transcription.

Accepted Answer

A) True 
 B)False

Question 14

A gene that undergoes rho-dependent termination has a mutation in the rut site. How will this influence transcriptional activity?

Accepted Answer

A)  Transcription will go on continuously 
B)  Transcription will stop immediately because RNA polymerase will sense there is a mutation 
C)  There will eventually be a termination sequence for transcription to end 
D)  None of the answers are correct 
A)  Transcription will go on continuously 
B)  Transcription will stop immediately because RNA polymerase will sense there is a mutation 
C)  There will eventually be a termination sequence for transcription to end 
D)  None of the answers are correct

Question 15

The unit of transcription at the molecular level is the gene.

Accepted Answer

A) True 
 B)False

Question 16

The term ribozyme is given to catalytic RNA molecules.

Accepted Answer

A) True 
 B)False

Question 17

What is the purpose of an SWI complex?

Accepted Answer

A)  Splice introns 
B)  Activate gene transcription 
C)  Form the open complex 
D)  Act as a mediator to RNA polymerase II 
A)  Splice introns 
B)  Activate gene transcription 
C)  Form the open complex 
D)  Act as a mediator to RNA polymerase II

Question 18

Which of the following allows the RNA polymerase II to interact with enhancers and silencers?

Accepted Answer

A)  Mediator 
B)  TFIIB 
C)  TFIID 
D)  Sigma factors 
E)  None of the answers are correct 
A)  Mediator 
B)  TFIIB 
C)  TFIID 
D)  Sigma factors 
E)  None of the answers are correct

Question 19

A ribozyme is a catalytic protein that assists in the processing of tRNA.
FALSE

Accepted Answer

A) True 
 B)False

Question 20

The closed promoter complex consists of all of the following, except .

Accepted Answer

A)  RNA polymerase 
B)  Transcription factors 
C)  Double helix DNA 
D)  Single-stranded DNA 
A)  RNA polymerase 
B)  Transcription factors 
C)  Double helix DNA 
D)  Single-stranded DNA

Exam 12: Gene Transcription and Rna Modification

What region in eukaryotic genes contains the majority of regulatory elements?

In eukaryotic organisms, the processing of the 45S rRNA into 5.8S, 18S, and 28S rRNA occurs where?

What structural motif is most commonly used by transcription factors in binding to DNA?

What do both the rho-dependent and rho-independent mechanisms of termination have in common?

Which of the following provides for a higher level of stability in the mRNA?

Which of the following forms of RNA encodes the sequence of amino acids for a functional protein?

What amino acid is the target of histone acetyltransferases?

Which of the following is the site for the start of transcription?

The consensus sequences are 5'TTGACA3' and 5'TATAAT3' at -35 and -10 respectively. Which of the following would be most easily recognized by σ factor?

What transcripts are made by RNA polymerase I in eukaryotes?

The formation of open complex usually forms in GC rich regions of DNA due to the decreased number of hydrogen bonds.

Sigma factor belongs to a general group of proteins called the transcription factors.

The process of RNA editing can alter the base sequence of the mRNA following transcription.

A gene that undergoes rho-dependent termination has a mutation in the rut site. How will this influence transcriptional activity?

The unit of transcription at the molecular level is the gene.

The term ribozyme is given to catalytic RNA molecules.

What is the purpose of an SWI complex?

Which of the following allows the RNA polymerase II to interact with enhancers and silencers?

A ribozyme is a catalytic protein that assists in the processing of tRNA. FALSE

The closed promoter complex consists of all of the following, except .

Overview of Genetics

Mendelian Inheritance

Reproduction and Chromosome Transmission

Extensions of Mendelian Inheritance

Non-Mendelian Inheritance

Genetic Linkage and Mapping in Eukaryotes

Genetic Transfer and Mapping in Bacteria and

Variation in Chromosome Structure and Number

Molecular Structure of Dna and Rna

Chromosome Organization and Molecular Structure

Dna Replication

Translation of Mrna

Gene Regulation in Bacteria and Bacteriophages

Gene Regulation in Eukaryotes

Gene Mutation and Dna Repair

Recombination and Transposition at the Molecular

Recombinant Dna Technology

Biotechnology

Genomics I: Analysis of Dna

Genomics II: Functional Genomics, Proteomics, and

Medical Genetics and Cancer

Developmental Genetics

Population Genetics

Quantitative Genetics

Evolutionary Genetics

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