Question 1

A condition called the _________________ syndrome can be secondary to lupus and may complicate pregnancy.

Accepted Answer

A) antiphospholipid 
B) antinuclear antibody 
C) immune complex 
D) plasma cell 
A) antiphospholipid 
B) antinuclear antibody 
C) immune complex 
D) plasma cell A

Question 2

A speckled pattern in antinuclear antibody (ANA) testing characterizes

Accepted Answer

A) dsDNA, histones, and DNA-histone complexes. 
B) anti-RNP and anti-Sm. 
C) centromere proteins A, B, and C. 
D) nuclear lamins A, B, and C and nuclear pore proteins. 
A) dsDNA, histones, and DNA-histone complexes. 
B) anti-RNP and anti-Sm. 
C) centromere proteins A, B, and C. 
D) nuclear lamins A, B, and C and nuclear pore proteins. B

Question 3

Match the interpretation of the ANA staining pattern to its respective antibody.
-Peripheral or rim

Accepted Answer

A) 4-6S RNP 
B) Antibody to nucleolar RNA 
C) Antibody to any extractable nuclear antigen devoid of DNA or histone 
D) nDNA 
A) 4-6S RNP 
B) Antibody to nucleolar RNA 
C) Antibody to any extractable nuclear antigen devoid of DNA or histone 
D) nDNA A

Question 4

Antibodies directed against ___________ cells, including the membrane molecules that mediate their responses, are regularly detected in patients with SLE.

Accepted Answer

A) T 
B) B 
C) plasma 
D) macrophage 
A) T 
B) B 
C) plasma 
D) macrophage

Question 5

Laboratory features of SLE include

Accepted Answer

A) the presence of ANAs. 
B) circulating anticoagulant and immune complexes. 
C) decreased levels of complement. 
D) All of the above. 
A) the presence of ANAs. 
B) circulating anticoagulant and immune complexes. 
C) decreased levels of complement. 
D) All of the above.

Question 6

The overall incidence of SLE has an increased frequency among

Accepted Answer

A) African Americans. 
B) Native Americans. 
C) Puerto Ricans. 
D) All of the above. 
A) African Americans. 
B) Native Americans. 
C) Puerto Ricans. 
D) All of the above.

Question 7

The site of deposition of immune complexes in systemic lupus erythematosus (SLE) is determined by

Accepted Answer

A) molecular configuration. 
B) immunoglobulin class. 
C) complement-fixing ability. 
D) All of the above. 
A) molecular configuration. 
B) immunoglobulin class. 
C) complement-fixing ability. 
D) All of the above.

Question 8

A major cellular immunologic feature of SLE is

Accepted Answer

A) lack of generalized suppressor T cell function. 
B) reduction of generalized suppressor T cell function. 
C) hyperproduction of helper T cells. 
D) All of the above. 
A) lack of generalized suppressor T cell function. 
B) reduction of generalized suppressor T cell function. 
C) hyperproduction of helper T cells. 
D) All of the above.

Question 9

In SLE, B lymphocytes exhibit

Accepted Answer

A) hyperactivity. 
B) uncontrolled production of antibodies. 
C) suppression of T cell activity. 
D) Both A and B. 
A) hyperactivity. 
B) uncontrolled production of antibodies. 
C) suppression of T cell activity. 
D) Both A and B.

Question 10

Patients with SLE characteristically manifest

Accepted Answer

A) a photosensitive facial rash. 
B) polyarthritis. 
C) dermatitis. 
D) All of the above. 
A) a photosensitive facial rash. 
B) polyarthritis. 
C) dermatitis. 
D) All of the above.

Question 11

One of the most potent inducers of abnormalities and clinical manifestations of SLE is

Accepted Answer

A) hydralazine. 
B) procainamide. 
C) isoniazid. 
D) Both A and B. 
A) hydralazine. 
B) procainamide. 
C) isoniazid. 
D) Both A and B.

Question 12

Which autoimmune disorder is indicated by an increased titer of anti-Sm (anti-Smith) antibody?

Accepted Answer

A) Rheumatoid arthritis 
B) Systemic lupus erythematosus 
C) Progressive systemic sclerosis 
D) Polymyositis 
A) Rheumatoid arthritis 
B) Systemic lupus erythematosus 
C) Progressive systemic sclerosis 
D) Polymyositis

Question 13

SLE is more common in

Accepted Answer

A) female infants. 
B) male infants. 
C) adult women. 
D) adult men. 
A) female infants. 
B) male infants. 
C) adult women. 
D) adult men.

Question 14

The SLE latex test utilizes latex particles coated with DNP (deoxyribonucleoprotein) and will produce macroscopic agglutination in patients with which of the following disorders:

Accepted Answer

A) SLE 
B) Rheumatoid arthritis 
C) Scleroderma. 
D) Sjogren's syndrome 
E) All of the above. 
A) SLE 
B) Rheumatoid arthritis 
C) Scleroderma. 
D) Sjogren's syndrome 
E) All of the above.

Question 15

Many of the clinical manifestations of systemic lupus erythematosus are a consequence of

Accepted Answer

A) tissue damage mediated by immune complexes. 
B) thrombocytopenia. 
C) antiphospholipid syndrome. 
D) antibodies to cell surface molecules. 
A) tissue damage mediated by immune complexes. 
B) thrombocytopenia. 
C) antiphospholipid syndrome. 
D) antibodies to cell surface molecules.

Question 16

The most frequent cause(s) of mortality in hospitalized patients with SLE and progressive renal involvement or CNS disease is (are)

Accepted Answer

A) infection 
B) anemia 
C) secondary malignancy 
D) Both A and B. 
A) infection 
B) anemia 
C) secondary malignancy 
D) Both A and B.

Question 17

Match the interpretation of the ANA staining pattern to its respective antibody.
-Nucleolar

Accepted Answer

A) 4-6S RNP 
B) Antibody to nucleolar RNA 
C) Antibody to any extractable nuclear antigen devoid of DNA or histone 
D) nDNA 
A) 4-6S RNP 
B) Antibody to nucleolar RNA 
C) Antibody to any extractable nuclear antigen devoid of DNA or histone 
D) nDNA

Question 18

A diffused or homogeneous pattern in antinuclear antibody (ANA) testing characterizes

Accepted Answer

A) nDNA, ds-DNA, histones, ssDNA, DNP, or histones. 
B) Sm, RNP, SS-A, SS-B, hnRNP, and others. 
C) centromere proteins A, B, and C. 
D) nuclear lamins A, B, and C and nuclear pore proteins. 
A) nDNA, ds-DNA, histones, ssDNA, DNP, or histones. 
B) Sm, RNP, SS-A, SS-B, hnRNP, and others. 
C) centromere proteins A, B, and C. 
D) nuclear lamins A, B, and C and nuclear pore proteins.

Question 19

Serologic assessment of renal disease in systemic lupus erythematosus (SLE) includes

Accepted Answer

A) cryoglobulin level assay. 
B) serum electrophoresis. 
C) serum creatinine level assay. 
D) urinary protein excretion. 
A) cryoglobulin level assay. 
B) serum electrophoresis. 
C) serum creatinine level assay. 
D) urinary protein excretion.

Question 20

The most common form of lupus is

Accepted Answer

A) discoid. 
B) systemic. 
C) drug-induced. 
A) discoid. 
B) systemic. 
C) drug-induced.

Exam 28: Systemic Lupus Erythematosus

A condition called the _________________ syndrome can be secondary to lupus and may complicate pregnancy.

A speckled pattern in antinuclear antibody (ANA) testing characterizes

Match the interpretation of the ANA staining pattern to its respective antibody. -Peripheral or rim

Antibodies directed against ___________ cells, including the membrane molecules that mediate their responses, are regularly detected in patients with SLE.

Laboratory features of SLE include

The overall incidence of SLE has an increased frequency among

The site of deposition of immune complexes in systemic lupus erythematosus (SLE) is determined by

A major cellular immunologic feature of SLE is

In SLE, B lymphocytes exhibit

Patients with SLE characteristically manifest

One of the most potent inducers of abnormalities and clinical manifestations of SLE is

Which autoimmune disorder is indicated by an increased titer of anti-Sm (anti-Smith) antibody?

SLE is more common in

The SLE latex test utilizes latex particles coated with DNP (deoxyribonucleoprotein) and will produce macroscopic agglutination in patients with which of the following disorders:

Many of the clinical manifestations of systemic lupus erythematosus are a consequence of

The most frequent cause(s) of mortality in hospitalized patients with SLE and progressive renal involvement or CNS disease is (are)

Match the interpretation of the ANA staining pattern to its respective antibody. -Nucleolar

A diffused or homogeneous pattern in antinuclear antibody (ANA) testing characterizes

Serologic assessment of renal disease in systemic lupus erythematosus (SLE) includes

The most common form of lupus is

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Rapid Testing

Precipitation and Particle Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Flow Cytometry

Molecular Laboratory Techniques

Infectious Diseases: Traditional and Alternate Diagnostic Techniques

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Cytomegalovirus

Infectious Mononucleosis

Viral Hepatitis

Rubella and Rubeola Infections

Primary and Acquired Immune Deficiency Syndromes

Hypersensitivity Reactions

Immunoproliferative Disorders

Tolerance, Autoimmunity, and Autoimmune Diseases

Rheumatoid Arthritis

Transplantation: Hla, Solid Organ, and Hematopoietic Stem Cells

Tumor Immunology and Up-To-Date Applications of Next-Generation Sequencing

Primer on Vaccines

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