Question 1

Pathogenic treponemes are cultivatable in artificial laboratory media.

Accepted Answer

A) True 
 B)False  False

Question 2

The type of antigen used in the RPR card procedure is

Accepted Answer

A) carbon particle cardiolipin. 
B) tanned sheep erythrocytes. 
C) sensitized latex particles. 
D) sensitized charcoal particles. 
A) carbon particle cardiolipin. 
B) tanned sheep erythrocytes. 
C) sensitized latex particles. 
D) sensitized charcoal particles. A

Question 3

Syphilis reverse sequence testing algorithms utilize

Accepted Answer

A) differential growth media followed by general support growth media for culturing. 
B) nontreponemal testing followed by treponemal testing to confirm reactive results. 
C) general support media followed by differential growth media for culturing. 
D) treponemal testing followed by nontreponemal testing to confirm reactive results. 
A) differential growth media followed by general support growth media for culturing. 
B) nontreponemal testing followed by treponemal testing to confirm reactive results. 
C) general support media followed by differential growth media for culturing. 
D) treponemal testing followed by nontreponemal testing to confirm reactive results. D

Question 4

The nontreponemal antibody produced by syphilis-infected patients can also be produced by patients with

Accepted Answer

A) other infectious diseases. 
B) leprosy, tuberculosis, leptospirosis, or malaria. 
C) autoimmune disorders, drug addiction, or old age. 
D) All of the above. 
A) other infectious diseases. 
B) leprosy, tuberculosis, leptospirosis, or malaria. 
C) autoimmune disorders, drug addiction, or old age. 
D) All of the above.

Question 5

Match the tests with the correct method used for each.
-RPR test

Accepted Answer

A) Treponemal method 
B) Nontreponemal method 
A) Treponemal method 
B) Nontreponemal method

Question 6

Match the stages of syphilis with the appropriate signs and symptoms. (Use each answer only once.)
-Spirochetemia

Accepted Answer

A) Diagnosis only by serologic methods 
B) Presence of gummas 
C) Development of a chancre 
D) Generalized illness followed by macular lesions in most patients 
E) Very early in infection, even before the first lesions 
A) Diagnosis only by serologic methods 
B) Presence of gummas 
C) Development of a chancre 
D) Generalized illness followed by macular lesions in most patients 
E) Very early in infection, even before the first lesions

Question 7

If an RPR assay is negative but has a rough appearance, what is an appropriate follow-up step?

Accepted Answer

A) Report as a negative assay result. 
B) Repeat the assay. 
C) Repeat the assay with serial dilutions. 
D) Request a new blood specimen for repeat testing. 
A) Report as a negative assay result. 
B) Repeat the assay. 
C) Repeat the assay with serial dilutions. 
D) Request a new blood specimen for repeat testing.

Question 8

Match the stages of syphilis with the appropriate signs and symptoms. (Use each answer only once.)
-Late (tertiary) syphilis

Accepted Answer

A) Diagnosis only by serologic methods 
B) Presence of gummas 
C) Development of a chancre 
D) Generalized illness followed by macular lesions in most patients 
E) Very early in infection, even before the first lesions 
A) Diagnosis only by serologic methods 
B) Presence of gummas 
C) Development of a chancre 
D) Generalized illness followed by macular lesions in most patients 
E) Very early in infection, even before the first lesions

Question 9

Match the diseases caused by bacteria closely related to Treponema pallidum with the appropriate description.
-Pinta

Accepted Answer

A) Common in the Caribbean, Latin America, Central Africa, and Far East 
B) Found only in Latin America; infection limited to the skin 
C) Found in eastern Mediterranean countries, the Balkans, and the cooler areas of North Africa 
A) Common in the Caribbean, Latin America, Central Africa, and Far East 
B) Found only in Latin America; infection limited to the skin 
C) Found in eastern Mediterranean countries, the Balkans, and the cooler areas of North Africa

Question 10

In infected donor blood, Treponema pallidum does not appear to survive in citrated blood stored at 4° C for more than ____ days(s).

Accepted Answer

A) 1 
B) 2 
C) 3 
D) 5 
A) 1 
B) 2 
C) 3 
D) 5

Question 11

Match the diseases caused by bacteria closely related to Treponema pallidum with the appropriate description.
-Yaws

Accepted Answer

A) Common in the Caribbean, Latin America, Central Africa, and Far East 
B) Found only in Latin America; infection limited to the skin 
C) Found in eastern Mediterranean countries, the Balkans, and the cooler areas of North Africa 
A) Common in the Caribbean, Latin America, Central Africa, and Far East 
B) Found only in Latin America; infection limited to the skin 
C) Found in eastern Mediterranean countries, the Balkans, and the cooler areas of North Africa

Question 12

Match the stages of syphilis with the appropriate signs and symptoms. (Use each answer only once.)
-Secondary syphilis

Accepted Answer

A) Diagnosis only by serologic methods 
B) Presence of gummas 
C) Development of a chancre 
D) Generalized illness followed by macular lesions in most patients 
E) Very early in infection, even before the first lesions 
A) Diagnosis only by serologic methods 
B) Presence of gummas 
C) Development of a chancre 
D) Generalized illness followed by macular lesions in most patients 
E) Very early in infection, even before the first lesions

Question 13

Match the diseases caused by bacteria closely related to Treponema pallidum with the appropriate description.
-Bejel

Accepted Answer

A) Common in the Caribbean, Latin America, Central Africa, and Far East 
B) Found only in Latin America; infection limited to the skin 
C) Found in eastern Mediterranean countries, the Balkans, and the cooler areas of North Africa 
A) Common in the Caribbean, Latin America, Central Africa, and Far East 
B) Found only in Latin America; infection limited to the skin 
C) Found in eastern Mediterranean countries, the Balkans, and the cooler areas of North Africa

Question 14

Before clinical or serologic manifestations, the incubation period for syphilis usually lasts

Accepted Answer

A) 3 to 7 days. 
B) 7 to 10 days. 
C) about 3 weeks. 
D) about 6 weeks. 
A) 3 to 7 days. 
B) 7 to 10 days. 
C) about 3 weeks. 
D) about 6 weeks.

Question 15

Match the tests with the correct method used for each.
-FTA-ABS test

Accepted Answer

A) Treponemal method 
B) Nontreponemal method 
A) Treponemal method 
B) Nontreponemal method

Question 16

Match the stages of syphilis with the appropriate signs and symptoms. (Use each answer only once.)
-Latent syphilis

Accepted Answer

A) Diagnosis only by serologic methods 
B) Presence of gummas 
C) Development of a chancre 
D) Generalized illness followed by macular lesions in most patients 
E) Very early in infection, even before the first lesions 
A) Diagnosis only by serologic methods 
B) Presence of gummas 
C) Development of a chancre 
D) Generalized illness followed by macular lesions in most patients 
E) Very early in infection, even before the first lesions

Question 17

Untreated congenital syphilis can lead to:

Accepted Answer

A) stillbirth. 
B) neonatal death. 
C) infant disorders. 
D) All of the above. 
A) stillbirth. 
B) neonatal death. 
C) infant disorders. 
D) All of the above.

Question 18

Match the tests with the correct method used for each.
-MHA-TP test

Accepted Answer

A) Treponemal method 
B) Nontreponemal method 
A) Treponemal method 
B) Nontreponemal method

Question 19

The substance detected by the RPR assay is

Accepted Answer

A) T. pallidum. 
B) a cardiolipin. 
C) a reagin. 
D) None of the above. 
A) T. pallidum. 
B) a cardiolipin. 
C) a reagin. 
D) None of the above.

Question 20

The term for nontreponemal antibodies produced by syphilis-infected patients against components of their own or other mammalian cells is

Accepted Answer

A) autoagglutinins. 
B) reagin antibodies. 
C) alloantibodies. 
D) nonsyphilis antibodies. 
A) autoagglutinins. 
B) reagin antibodies. 
C) alloantibodies. 
D) nonsyphilis antibodies.

Exam 17: Syphilis

Pathogenic treponemes are cultivatable in artificial laboratory media.

The type of antigen used in the RPR card procedure is

Syphilis reverse sequence testing algorithms utilize

The nontreponemal antibody produced by syphilis-infected patients can also be produced by patients with

Match the tests with the correct method used for each. -RPR test

Match the stages of syphilis with the appropriate signs and symptoms. (Use each answer only once.) -Spirochetemia

If an RPR assay is negative but has a rough appearance, what is an appropriate follow-up step?

Match the stages of syphilis with the appropriate signs and symptoms. (Use each answer only once.) -Late (tertiary) syphilis

Match the diseases caused by bacteria closely related to Treponema pallidum with the appropriate description. -Pinta

In infected donor blood, Treponema pallidum does not appear to survive in citrated blood stored at 4° C for more than ____ days(s).

Match the diseases caused by bacteria closely related to Treponema pallidum with the appropriate description. -Yaws

Match the stages of syphilis with the appropriate signs and symptoms. (Use each answer only once.) -Secondary syphilis

Match the diseases caused by bacteria closely related to Treponema pallidum with the appropriate description. -Bejel

Before clinical or serologic manifestations, the incubation period for syphilis usually lasts

Match the tests with the correct method used for each. -FTA-ABS test

Match the stages of syphilis with the appropriate signs and symptoms. (Use each answer only once.) -Latent syphilis

Untreated congenital syphilis can lead to:

Match the tests with the correct method used for each. -MHA-TP test

The substance detected by the RPR assay is

The term for nontreponemal antibodies produced by syphilis-infected patients against components of their own or other mammalian cells is

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Rapid Testing

Precipitation and Particle Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Flow Cytometry

Molecular Laboratory Techniques

Infectious Diseases: Traditional and Alternate Diagnostic Techniques

Streptococcal Infections

Vector-Borne Diseases

Toxoplasmosis

Cytomegalovirus

Infectious Mononucleosis

Viral Hepatitis

Rubella and Rubeola Infections

Primary and Acquired Immune Deficiency Syndromes

Hypersensitivity Reactions

Immunoproliferative Disorders

Tolerance, Autoimmunity, and Autoimmune Diseases

Systemic Lupus Erythematosus

Rheumatoid Arthritis

Transplantation: Hla, Solid Organ, and Hematopoietic Stem Cells

Tumor Immunology and Up-To-Date Applications of Next-Generation Sequencing

Primer on Vaccines

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