Question 1

Match the infections with the appropriate immunoglobulin response.
-Primary infection

Accepted Answer

A) IgG, but IgM response unknown 
B) Specific IgM antibody response 
C) IgG (no detectable IgM) 
A) IgG, but IgM response unknown 
B) Specific IgM antibody response 
C) IgG (no detectable IgM) B

Question 2

The blood product that can transmit cytomegalovirus (CMV) is

Accepted Answer

A) platelet concentration. 
B) washed red blood cells (RBCs). 
C) leukocyte (WB
C)  concentrates. 
D) plasma. 
A) platelet concentration. 
B) washed red blood cells (RBCs). 
C) leukocyte (WB
C)  concentrates. 
D) plasma. C

Question 3

Match the infections with the appropriate immunoglobulin response.
-Reactivation of latent infection in seropositive IgG patient

Accepted Answer

A) IgG, but IgM response unknown 
B) Specific IgM antibody response 
C) IgG (no detectable IgM) 
A) IgG, but IgM response unknown 
B) Specific IgM antibody response 
C) IgG (no detectable IgM) C

Question 4

Patients with the highest risk of mortality from CMV are

Accepted Answer

A) fetuses. 
B) immunocompromised individuals. 
C) allograft transplant, seronegative patients who receive tissue from a seropositive donor. 
D) All of the above. 
A) fetuses. 
B) immunocompromised individuals. 
C) allograft transplant, seronegative patients who receive tissue from a seropositive donor. 
D) All of the above.

Question 5

Individuals with the greatest risk of developing CMV infection are

Accepted Answer

A) fetuses. 
B) immunocompromised individuals. 
C) persons older than 40 years. 
D) Both A and B. 
A) fetuses. 
B) immunocompromised individuals. 
C) persons older than 40 years. 
D) Both A and B.

Question 6

Match the three types of CMV infection associated with blood transfusion with their appropriate description.
-Primary infection

Accepted Answer

A) CMV strain in the donor's blood that differs from the strain originally infecting the recipient 
B) Seronegative recipient is transfused with blood from actively or latently infected donor 
C) Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor 
A) CMV strain in the donor's blood that differs from the strain originally infecting the recipient 
B) Seronegative recipient is transfused with blood from actively or latently infected donor 
C) Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor

Question 7

Congenital CMV infection is the most common intrauterine infection.

Accepted Answer

A) True 
 B)False

Question 8

Cytomegalovirus (CMV) is related to

Accepted Answer

A) Epstein-Barr virus (EBV). 
B) herpes simplex 1. 
C) herpes simplex 2. 
D) All of the above. 
A) Epstein-Barr virus (EBV). 
B) herpes simplex 1. 
C) herpes simplex 2. 
D) All of the above.

Question 9

Primary and recurrent maternal CMV infections cannot be transmitted in utero.

Accepted Answer

A) True 
 B)False

Question 10

Herpesviruses all share the characteristic of being

Accepted Answer

A) rare viruses. 
B) associated with bioterrorism agents. 
C) cell-associated. 
D) only found in the United States. 
A) rare viruses. 
B) associated with bioterrorism agents. 
C) cell-associated. 
D) only found in the United States.

Question 11

A fourfold rise in IgG antibody titer suggests but does not prove __________ CMV infection.

Accepted Answer

A) recent 
B) latent 
C) reactivated 
D) chronic 
A) recent 
B) latent 
C) reactivated 
D) chronic

Question 12

Antibodies to early antigens can be associated with

Accepted Answer

A) primary infection. 
B) reactivated infection. 
C) latent infection. 
D) Either A or B. 
A) primary infection. 
B) reactivated infection. 
C) latent infection. 
D) Either A or B.

Question 13

Forms of transfusion-acquired cytomegalovirus (CMV) infection include all the following except

Accepted Answer

A) primary infection. 
B) reactivated infection. 
C) reinfection with a different strain. 
D) latent infection. 
A) primary infection. 
B) reactivated infection. 
C) reinfection with a different strain. 
D) latent infection.

Question 14

A latent CMV infection is defined as

Accepted Answer

A) persistent infections characterized by periods of reactivation. 
B) the presence of genetic information in an unexpressed state in the host cell. 
C) a condition of a dynamic relationship between the virus and host. 
D) All of the above. 
A) persistent infections characterized by periods of reactivation. 
B) the presence of genetic information in an unexpressed state in the host cell. 
C) a condition of a dynamic relationship between the virus and host. 
D) All of the above.

Question 15

CMV serology is recommended for immunocompromised patients.

Accepted Answer

A) True 
 B)False

Question 16

The preferred method for diagnosis of CMV infection is

Accepted Answer

A) culture of virus. 
B) polymerase chain reaction (PCR). 
C) latex agglutination. 
D) Either A or B. 
A) culture of virus. 
B) polymerase chain reaction (PCR). 
C) latex agglutination. 
D) Either A or B.

Question 17

The great majority of infections in allograft recipients:

Accepted Answer

A) are transmitted by a donated organ. 
B) arise from the reactivation of the recipient's latent virus. 
C) are transmitted through transfusion of packed red blood cells. 
D) Both A and B. 
A) are transmitted by a donated organ. 
B) arise from the reactivation of the recipient's latent virus. 
C) are transmitted through transfusion of packed red blood cells. 
D) Both A and B.

Question 18

CMV infection in normal adults and children is

Accepted Answer

A) associated with CMV hepatitis as well. 
B) asymptomatic in most patients. 
C) occasionally a self-limited, mononucleosis-like syndrome. 
D) All of the above. 
A) associated with CMV hepatitis as well. 
B) asymptomatic in most patients. 
C) occasionally a self-limited, mononucleosis-like syndrome. 
D) All of the above.

Question 19

All the herpesviruses are relatively large, enveloped ________ viruses.

Accepted Answer

A) DNA 
B) RNA 
C) retro 
D) Both B and C. 
A) DNA 
B) RNA 
C) retro 
D) Both B and C.

Question 20

Cells of tissues that can harbor CMV include

Accepted Answer

A) peripheral blood leukocytes. 
B) transplanted tissues 
C) prostate tissue. 
D) Both A and B. 
A) peripheral blood leukocytes. 
B) transplanted tissues 
C) prostate tissue. 
D) Both A and B.

Exam 20: Cytomegalovirus

Match the infections with the appropriate immunoglobulin response. -Primary infection

The blood product that can transmit cytomegalovirus (CMV) is

Match the infections with the appropriate immunoglobulin response. -Reactivation of latent infection in seropositive IgG patient

Patients with the highest risk of mortality from CMV are

Individuals with the greatest risk of developing CMV infection are

Match the three types of CMV infection associated with blood transfusion with their appropriate description. -Primary infection

Congenital CMV infection is the most common intrauterine infection.

Cytomegalovirus (CMV) is related to

Primary and recurrent maternal CMV infections cannot be transmitted in utero.

Herpesviruses all share the characteristic of being

A fourfold rise in IgG antibody titer suggests but does not prove __________ CMV infection.

Antibodies to early antigens can be associated with

Forms of transfusion-acquired cytomegalovirus (CMV) infection include all the following except

A latent CMV infection is defined as

CMV serology is recommended for immunocompromised patients.

The preferred method for diagnosis of CMV infection is

The great majority of infections in allograft recipients:

CMV infection in normal adults and children is

All the herpesviruses are relatively large, enveloped ________ viruses.

Cells of tissues that can harbor CMV include

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Rapid Testing

Precipitation and Particle Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Flow Cytometry

Molecular Laboratory Techniques

Infectious Diseases: Traditional and Alternate Diagnostic Techniques

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Infectious Mononucleosis

Viral Hepatitis

Rubella and Rubeola Infections

Primary and Acquired Immune Deficiency Syndromes

Hypersensitivity Reactions

Immunoproliferative Disorders

Tolerance, Autoimmunity, and Autoimmune Diseases

Systemic Lupus Erythematosus

Rheumatoid Arthritis

Transplantation: Hla, Solid Organ, and Hematopoietic Stem Cells

Tumor Immunology and Up-To-Date Applications of Next-Generation Sequencing

Primer on Vaccines

Filters