Exam 17: Learning and Memory

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Review the research pertaining to medial temporal lobe structures and declarative memory.

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The research pertaining to medial temporal lobe structures and declarative memory has shown that these structures, including the hippocampus and surrounding regions, play a crucial role in the formation and retrieval of declarative memories. Declarative memory refers to the conscious recollection of facts and events, and studies have consistently demonstrated the importance of the medial temporal lobe in this process.

Research using various techniques such as neuroimaging, lesion studies, and animal models has provided evidence for the involvement of the medial temporal lobe in declarative memory. For example, patients with damage to the hippocampus and surrounding areas often exhibit profound deficits in forming new declarative memories, while retaining other cognitive functions. Additionally, neuroimaging studies have shown increased activity in the medial temporal lobe during tasks that require the encoding and retrieval of declarative memories.

Furthermore, research has also highlighted the specific contributions of different regions within the medial temporal lobe to declarative memory. For instance, the hippocampus is thought to be particularly important for the initial encoding and consolidation of declarative memories, while the surrounding cortical regions may play a role in the retrieval and integration of these memories.

Overall, the research on medial temporal lobe structures and declarative memory has provided valuable insights into the neural mechanisms underlying our ability to remember past events and information. Understanding these processes is not only important for advancing our knowledge of human cognition, but also has implications for the diagnosis and treatment of memory-related disorders.

In LTP formation, nitric oxide and arachidonic acid may serve as

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Compared to animals placed in impoverished conditions, animals kept in enriched conditions have been found to have heavier brains, due primarily to increases in the

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Research on patient H.M. and others with similar brain damage confirmed that there are two types of memory, distinguishable as

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In the hippocampus, commissural fibers carry information from the

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NMDA receptors induce LTP

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In the formation of LTP, the entry of Ca2+ ions into the neuron activates _______, which are enzymes that _______ the activity of intracellular proteins.

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Adult mice living in enriched conditions produce new neurons in the

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Describe how different protein kinases are important in LTP. Relate their action to the actions of CREB and its effect on synaptic remodeling.

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In mammals, the physical basis of a memory formed by learning a particular task, which is called the _______, is thought to be encoded by changes in the activity of a circuit of neurons, not just one neuron.

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The three successive events that are necessary for recall of a past event are encoding, _______, and retrieval.

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It appears that the medial temporal system is not required for

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According to Hebb's notion of cell assemblies, information can be stored by groups of neurons that are

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In order to find evidence of an engram, optogenetics has been used to turn _______ neurons that _______ a conditioned fear response.

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Describe the circuitry in the Aplysia siphon withdrawal reflex, and explain cellular and molecular changes to this circuit as a result of training.

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Eye-blink conditioning is an example of _______ conditioning and has been used to study mammalian cerebellar circuits.

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In mice, genetic deletion of CREB

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Which statement about memory is true?

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Matching -Sensory buffer _____

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H.M.'s performance on the mirror tracing task showed that he could acquire a kind of _______ memory.

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