Question 1

In the early stages of T-cell activation, __________________.

Accepted Answer

A)  T cells are retained in lymphoid organs, allowing the cytokine exposure necessary to continue activation 
B)  enhanced T cell migration to peripheral sites of injury and infection following cytokine exposure 
C)  the T cells transiently secrete IL-2 
D)  the T cells bind IL-2 with high affinity to inhibit apoptosis 
A)  T cells are retained in lymphoid organs, allowing the cytokine exposure necessary to continue activation 
B)  enhanced T cell migration to peripheral sites of injury and infection following cytokine exposure 
C)  the T cells transiently secrete IL-2 
D)  the T cells bind IL-2 with high affinity to inhibit apoptosis

Question 2

Patients suffering from an infection begin feeling better after about 5-7 days of their illness because _____________. (Select all that apply)

Accepted Answer

A)  their antibody titer is peaking 
B)  multivalent IgM pentameric antibodies have eliminated a lot of the pathogens 
C)  antibody class switching is responsible for the production of a secondary wave of IgA secretion 
D)  antibody affinity is declining 
A)  their antibody titer is peaking 
B)  multivalent IgM pentameric antibodies have eliminated a lot of the pathogens 
C)  antibody class switching is responsible for the production of a secondary wave of IgA secretion 
D)  antibody affinity is declining

Question 3

_______is the antibody class that crosses the placenta to provide passive immunity to neonates.

Accepted Answer

A)  IgG 
B)  IgA 
C)  IgM 
D)  IgE 
A)  IgG 
B)  IgA 
C)  IgM 
D)  IgE

Question 4

_______________ is a class of molecule that can both chemically recognize the presence of antigens and participate in the resulting immune response. (Select all that apply)

Accepted Answer

A)  CD4 
B)  TCR 
C)  MHC molecules 
D)  antibodies 
A)  CD4 
B)  TCR 
C)  MHC molecules 
D)  antibodies

Question 5

A proteasome is ____________.

Accepted Answer

A)  the cleft in the top of a Class II MHC molecule 
B)  the channel in the ER that transports protein fragments inside to bind with Class I MHC molecules, forming a neoantigen 
C)  a phagolysosome 
D)  a tube-like protein complex that unfolds and degrades foreign cytosolic proteins to generate the peptide fragments of neoantigens 
A)  the cleft in the top of a Class II MHC molecule 
B)  the channel in the ER that transports protein fragments inside to bind with Class I MHC molecules, forming a neoantigen 
C)  a phagolysosome 
D)  a tube-like protein complex that unfolds and degrades foreign cytosolic proteins to generate the peptide fragments of neoantigens

Question 6

Antigen-processing pathways correlate with the location of what cellular feature?

Accepted Answer

A)  Class I MHC molecules 
B)  Class II MHC molecules 
C)  the foreign protein 
D)  the neoantigen 
A)  Class I MHC molecules 
B)  Class II MHC molecules 
C)  the foreign protein 
D)  the neoantigen

Question 7

Transplant failure can be reduced by ____________. (Select all that apply)

Accepted Answer

A)  matching the Class I MHC molecules between donor and recipient 
B)  matching the Class II MHC molecules between donor and recipient 
C)  maximizing CD4 levels expressed on T cells 
D)  minimizing CD45Rc levels expressed on T cells 
A)  matching the Class I MHC molecules between donor and recipient 
B)  matching the Class II MHC molecules between donor and recipient 
C)  maximizing CD4 levels expressed on T cells 
D)  minimizing CD45Rc levels expressed on T cells

Question 8

Indicate the correct sequence of events in the maturation of B and T lymphocytes.
1) Immature T cells in thymus and immature B cells in bone marrow undergo rapid mitosis under the influence of specific cytokines
2) Segments of genes that produce lymphocyte receptors are spliced and rearranged to produce almost 1018 different receptors.
3) Cells failing to produce a functional receptor are eliminated via apoptosis
4) Antigen receptors on immature T and B cells are screened during positive selection so that only useful receptors are generated.
5) After passing positive selection, T and B cells complete maturation process and start their patrol of the body for the presence of pathogens.

Accepted Answer

A)  1, 2, 3, 4, 5 
B)  5, 4, 3, 2, 1 
C)  1, 2, 4, 3, 5 
D)  1, 4, 3, 2, 5 
A)  1, 2, 3, 4, 5 
B)  5, 4, 3, 2, 1 
C)  1, 2, 4, 3, 5 
D)  1, 4, 3, 2, 5

Question 9

___________ promotes rapid antigen phagocytosis.

Accepted Answer

A)  Opsonization 
B)  Complement activation 
C)  Neutralization 
D)  Antibody-dependent cell-mediated cytotoxicity 
A)  Opsonization 
B)  Complement activation 
C)  Neutralization 
D)  Antibody-dependent cell-mediated cytotoxicity

Question 10

Which of the following T cell subsets express CD4 glycoproteins. (Select all that apply)

Accepted Answer

A)  Helper T cells 
B)  Regulatory T cells 
C)  Cytotoxic T cells 
D)  Natural Killer T cells 
A)  Helper T cells 
B)  Regulatory T cells 
C)  Cytotoxic T cells 
D)  Natural Killer T cells

In the early stages of T-cell activation, __________________.

Patients suffering from an infection begin feeling better after about 5-7 days of their illness because _____________. (Select all that apply)

_______is the antibody class that crosses the placenta to provide passive immunity to neonates.

_______________ is a class of molecule that can both chemically recognize the presence of antigens and participate in the resulting immune response. (Select all that apply)

A proteasome is ____________.

Antigen-processing pathways correlate with the location of what cellular feature?

Transplant failure can be reduced by ____________. (Select all that apply)

___________ promotes rapid antigen phagocytosis.

Which of the following T cell subsets express CD4 glycoproteins. (Select all that apply)

Microbial World

An Introduction to the Chemical Basis of Life

The Biochemistry of Macromolecules

Microscopy

Prokaryote Organisms

Eukaryotic Cells

Eukaryotic Organisms

Viruses and Infectious Particles

Metabolism

Microbial Genetics and Genetic Engineering

Microbial Growth and Control

Antimicrobial Agents

Innate Immunity

Vaccination, Immunoassays, and Immune Disorders

Microbial Pathogenesis

Epidemiology and Infection Control

Diseases of the Respiratory System

Diseases of the Skin and Eyes

Diseases of the Gastrointestinal System

Diseases of the Urogenital System

Diseases of the Nervous System

Diseases of the Cardiovascular and Lymphatic Systems

Environmental and Industrial Microbiology

Filters

Exam 14: Adaptive Immunity

In the early stages of T-cell activation, __________________.

Patients suffering from an infection begin feeling better after about 5-7 days of their illness because _____________. (Select all that apply)

_______is the antibody class that crosses the placenta to provide passive immunity to neonates.

_______________ is a class of molecule that can both chemically recognize the presence of antigens and participate in the resulting immune response. (Select all that apply)

A proteasome is ____________.

Antigen-processing pathways correlate with the location of what cellular feature?

Transplant failure can be reduced by ____________. (Select all that apply)

___________ promotes rapid antigen phagocytosis.

Which of the following T cell subsets express CD4 glycoproteins. (Select all that apply)

Microbial World

An Introduction to the Chemical Basis of Life

The Biochemistry of Macromolecules

Microscopy

Prokaryote Organisms

Eukaryotic Cells

Eukaryotic Organisms

Viruses and Infectious Particles

Metabolism

Microbial Genetics and Genetic Engineering

Microbial Growth and Control

Antimicrobial Agents

Innate Immunity

Vaccination, Immunoassays, and Immune Disorders

Microbial Pathogenesis

Epidemiology and Infection Control

Diseases of the Respiratory System

Diseases of the Skin and Eyes

Diseases of the Gastrointestinal System

Diseases of the Urogenital System

Diseases of the Nervous System

Diseases of the Cardiovascular and Lymphatic Systems

Environmental and Industrial Microbiology

Filters