Question 1

Heat shock proteins are those stable at higher temperatures.

Accepted Answer

A) True 
 B)False

Question 2

A helical wheel can be used to show

Accepted Answer

A) the pitch of a helix structure. 
B) the amphipathic nature of a helix. 
C) DNA binding. 
D) pleated sheets. 
A) the pitch of a helix structure. 
B) the amphipathic nature of a helix. 
C) DNA binding. 
D) pleated sheets.

Question 3

The porphyrin prosthetic group is held into the interior of globin molecules by covalent bonds to specific amino acid residues.

Accepted Answer

A) True 
 B)False

Question 4

Interactomes describe interactions between

Accepted Answer

A) DNA and RNA. 
B) RNA polymerase and RNA. 
C) DNA polymerase and DNA. 
D) Proteins with other proteins. 
A) DNA and RNA. 
B) RNA polymerase and RNA. 
C) DNA polymerase and DNA. 
D) Proteins with other proteins.

Question 5

Proteins often consist of multiple subunits so that they may have different functions under different conditions.

Accepted Answer

A) True 
 B)False

Question 6

Cooperative binding of oxygen by hemoglobin

Accepted Answer

A) is induced by hemoglobin. 
B) is a result of different affinities for oxygen by each subunit protein. 
C) is induced by oxygenation. 
D) is a result of interaction with myoglobin. 
A) is induced by hemoglobin. 
B) is a result of different affinities for oxygen by each subunit protein. 
C) is induced by oxygenation. 
D) is a result of interaction with myoglobin.

Question 7

How many monomers are there in an oligomeric protein designated αβ2γ2?

Accepted Answer

A) 2 
B) 3 
C) 4 
D) 5 
E) Not given. 
A) 2 
B) 3 
C) 4 
D) 5 
E) Not given.

Question 8

The amino acid that destabilizes alpha-helical structures and is usually found at the ends of alpha helices is

Accepted Answer

A) glycine. 
B) alanine. 
C) asparagine. 
D) glutamate. 
A) glycine. 
B) alanine. 
C) asparagine. 
D) glutamate.

Question 9

________ received a Nobel Prize in 1964 for determining the structure of vitamin B12.He/she also solved the structure of penicillin in 1947 and developed many techniques used in the study of large proteins.

Accepted Answer

A) Max Perutz 
B) Linus Pauling 
C) Rosalind Franklin 
D) Dorothy Crowfoot 
A) Max Perutz 
B) Linus Pauling 
C) Rosalind Franklin 
D) Dorothy Crowfoot

Question 10

Computers are used to advance the understanding of three-dimensional protein structure by

Accepted Answer

A) determining the specific sequence of amino acids. 
B) finding repeating subunit patterns. 
C) calculating atomic positions from X-ray diffraction patterns. 
D) collimating X-ray beams. 
A) determining the specific sequence of amino acids. 
B) finding repeating subunit patterns. 
C) calculating atomic positions from X-ray diffraction patterns. 
D) collimating X-ray beams.

Question 11

A change from one conformation of a molecule to another involves ________.

Accepted Answer

A) rotation about bonds only 
B) breaking and reforming of covalent bonds 
C) inversion about a center of symmetry 
D) Any of the above 
A) rotation about bonds only 
B) breaking and reforming of covalent bonds 
C) inversion about a center of symmetry 
D) Any of the above

Question 12

Which is not an example of an oligomeric protein?

Accepted Answer

A) Cytochrome c. 
B) Potassium channel protein. 
C) MS2 capsid protein. 
D) Hemoglobin. 
E) Bacterial photosynthetic reaction center. 
A) Cytochrome c. 
B) Potassium channel protein. 
C) MS2 capsid protein. 
D) Hemoglobin. 
E) Bacterial photosynthetic reaction center.

Question 13

The conformation of the backbone of a polypeptide is described completely by the angle(s)of rotation about which bond(s)?

Accepted Answer

A) The peptide bond only. 
B) N-Cα only. 
C) N-Cα,Cα-C and C-N bonds. 
D) N-Cα and Cα-C bonds only. 
A) The peptide bond only. 
B) N-Cα only. 
C) N-Cα,Cα-C and C-N bonds. 
D) N-Cα and Cα-C bonds only.

Question 14

β-strands are a type of secondary structure.

Accepted Answer

A) True 
 B)False

Question 15

The ________ is the single shape a protein adopts under physiological conditions.

Accepted Answer

A) minimal configuration 
B) native conformation 
C) primary structure 
D) most stable enantiomer 
A) minimal configuration 
B) native conformation 
C) primary structure 
D) most stable enantiomer

Question 16

The amount of energy required to denature a protein is often small.

Accepted Answer

A) True 
 B)False

Question 17

Supersecondary structures that contain recognizable combinations of α-helices,β-strands and loops (e.g.the Greek Key)are called ________.

Accepted Answer

A) domains 
B) folds 
C) homologous regions 
D) motifs 
A) domains 
B) folds 
C) homologous regions 
D) motifs

Question 18

Disulfide bond formation between two cysteine residues appropriately located in a polypeptide chain drives protein folding into the proper configuration.

Accepted Answer

A) True 
 B)False

Question 19

The principle forces holding subunits of an oligomeric protein to each other are ________.

Accepted Answer

A) peptide bonds 
B) hydrophobic interactions 
C) covalent bonds 
D) disulfide bonds 
A) peptide bonds 
B) hydrophobic interactions 
C) covalent bonds 
D) disulfide bonds

Question 20

Ascorbic acid is necessary for the formation of hydroxyproline and hydroxylysine residues before they are incorporated into the collagen protein molecule.

Accepted Answer

A) True 
 B)False

Exam 4: Proteins: Three-Dimensional Structure and Function

Heat shock proteins are those stable at higher temperatures.

A helical wheel can be used to show

The porphyrin prosthetic group is held into the interior of globin molecules by covalent bonds to specific amino acid residues.

Interactomes describe interactions between

Proteins often consist of multiple subunits so that they may have different functions under different conditions.

Cooperative binding of oxygen by hemoglobin

How many monomers are there in an oligomeric protein designated αβ2γ2?

The amino acid that destabilizes alpha-helical structures and is usually found at the ends of alpha helices is

________ received a Nobel Prize in 1964 for determining the structure of vitamin B12.He/she also solved the structure of penicillin in 1947 and developed many techniques used in the study of large proteins.

Computers are used to advance the understanding of three-dimensional protein structure by

A change from one conformation of a molecule to another involves ________.

Which is not an example of an oligomeric protein?

The conformation of the backbone of a polypeptide is described completely by the angle(s)of rotation about which bond(s)?

β-strands are a type of secondary structure.

The ________ is the single shape a protein adopts under physiological conditions.

The amount of energy required to denature a protein is often small.

Supersecondary structures that contain recognizable combinations of α-helices,β-strands and loops (e.g.the Greek Key)are called ________.

Disulfide bond formation between two cysteine residues appropriately located in a polypeptide chain drives protein folding into the proper configuration.

The principle forces holding subunits of an oligomeric protein to each other are ________.

Ascorbic acid is necessary for the formation of hydroxyproline and hydroxylysine residues before they are incorporated into the collagen protein molecule.

Introduction to Biochemistry

Water

Amino Acids and the Primary Structures of Proteins

Properties of Enzymes

Mechanisms of Enzymes

Coenzymes and Vitamins

Carbohydrates

Lipids and Membranes

Introduction to Metabolism

Glycolysis

Gluconeogenesis, the Pentose Phosphate Pathway, and Glycogen Metabolism

The Citric Acid Cycle

Electron Transport and Atp Synthesis

Photosynthesis

Lipid Metabolism

Amino Acid Metabolism

Nucleotide Metabolism

Nucleic Acids

DNA Replication, repair, and Recombination

Transcription and RNA Processing

Protein Synthesis

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