Question 1

Which of the following are examples of suppressor mutations?

Accepted Answer

A)  an intragenic mutation that restores protein structure 
B)  an intergenic mutation that increases the activity of a protein performing the same function as the mutated protein 
C)  an intergenic mutation that activates a transcription factor that dramatically upregulates expression of the mutant protein 
D)  All of the answers are possible suppressor mutations. 
A)  an intragenic mutation that restores protein structure 
B)  an intergenic mutation that increases the activity of a protein performing the same function as the mutated protein 
C)  an intergenic mutation that activates a transcription factor that dramatically upregulates expression of the mutant protein 
D)  All of the answers are possible suppressor mutations. D

Question 2

The Ames test may be used to determine if an agent is a mutagen.

Accepted Answer

A) True 
 B)False  True

Question 3

The complete loss of either a guanine or adenine from DNA is an example of ________.

Accepted Answer

A)  depurination 
B)  tautomeric shifts 
C)  deamination 
D)  None of the answers are correct. 
A)  depurination 
B)  tautomeric shifts 
C)  deamination 
D)  None of the answers are correct. A

Question 4

How does position effect influence gene expression?

Accepted Answer

A)  The movement of the genetic material on the chromosome by inversions or translocations may place a coding sequence near a new regulatory region, thus activating the expression of the gene. 
B)  The movement of the gene may place it into a region that is highly condensed. 
C)  The movement of a gene may remove it from its normal promoter, thus silencing the gene. 
D)  All of the answers are correct. 
A)  The movement of the genetic material on the chromosome by inversions or translocations may place a coding sequence near a new regulatory region, thus activating the expression of the gene. 
B)  The movement of the gene may place it into a region that is highly condensed. 
C)  The movement of a gene may remove it from its normal promoter, thus silencing the gene. 
D)  All of the answers are correct.

Question 5

Reverse mutations involve changing a wild-type allele to a mutant allele.

Accepted Answer

A) True 
 B)False

Question 6

Ethyl methanesulfonate (EMS)is an example of a deaminating agent.

Accepted Answer

A) True 
 B)False

Question 7

Which of the following integrate into the double-helix of DNA,interfering with DNA replication?

Accepted Answer

A)  EMS 
B)  nitrous acid 
C)  5BU 
D)  acridine dyes 
A)  EMS 
B)  nitrous acid 
C)  5BU 
D)  acridine dyes

Question 8

If a point mutation increases the number of offspring an organism can produce,it would be called a ________ mutation.

Accepted Answer

A)  neutral 
B)  lethal 
C)  beneficial 
D)  conditional 
E)  deleterious 
A)  neutral 
B)  lethal 
C)  beneficial 
D)  conditional 
E)  deleterious

Question 9

Breakpoints in chromosome can lead to mutant phenotypes when they occur in the middle of a gene.

Accepted Answer

A) True 
 B)False

Question 10

Which environmental agent shown can induce mutations?

Accepted Answer

A)  UV radiation 
B)  x-rays 
C)  gamma rays 
D)  All of the answers are correct. 
A)  UV radiation 
B)  x-rays 
C)  gamma rays 
D)  All of the answers are correct.

Question 11

When guanine is oxidized into 8-oxoguanine,it will base pair with adenine during DNA replication,causing a transversion mutation.

Accepted Answer

A) True 
 B)False

Question 12

Match between columns
                        Premises: Converts an amino-acid codon to a termination codon
When a change in a single amino acid does not have a noticeable effect on the protein
Involves the addition or deletion of nucleotides
Changes a single amino acid in the protein
Does not involve a change in the amino acid structure of the protein

Accepted Answer

The Answer of Nonsense and Frameshift and Neutral and Silent is...

Question 13

Mutations that change the configuration of a protein at a specific temperature are called ________ mutations.

Accepted Answer

A)  neutral 
B)  beneficial 
C)  deleterious 
D)  conditional 
A)  neutral 
B)  beneficial 
C)  deleterious 
D)  conditional

Question 14

Which of the following is an example of a base analog?

Accepted Answer

A)  EMS 
B)  nitrous acid 
C)  5BU 
D)  nitrogen mustards 
E)  acridine dyes 
A)  EMS 
B)  nitrous acid 
C)  5BU 
D)  nitrogen mustards 
E)  acridine dyes

Question 15

Somatic cells are those that give rise to sperm and egg cells.

Accepted Answer

A) True 
 B)False

Question 16

The wild-type eye color of Drosophila is red.A single-base mutation occurs that produces a white eye color.Which of the following is correct regarding this mutation?

Accepted Answer

A)  It is an example of a mutation that alters protein function. 
B)  Individuals with white eyes are called reversions. 
C)  It would be an example of a silent mutation. 
D)  All of the answers are correct. 
A)  It is an example of a mutation that alters protein function. 
B)  Individuals with white eyes are called reversions. 
C)  It would be an example of a silent mutation. 
D)  All of the answers are correct.

Question 17

Which repair process can use an enzyme called photolyase?

Accepted Answer

A)  homologous recombination repair 
B)  direct repair 
C)  base excision repair 
D)  mismatch repair 
E)  nucleotide excision repair 
A)  homologous recombination repair 
B)  direct repair 
C)  base excision repair 
D)  mismatch repair 
E)  nucleotide excision repair

Question 18

After screening a colony of bacteria for a given gene,you discover 100 mutant colonies out of 3 million total colonies.What is the mutation frequency for this gene in the population?

Accepted Answer

A)  1.0 x 10⁵ 
B)  1.0 x 10⁻⁵ 
C)  3.0 x 10⁵ 
D)  3.3 x 10⁻⁵ 
A)  1.0 x 10⁵ 
B)  1.0 x 10⁻⁵ 
C)  3.0 x 10⁵ 
D)  3.3 x 10⁻⁵

Question 19

Homologous recombination repair requires the presence of a sister chromatid.

Accepted Answer

A) True 
 B)False

Question 20

The mutation frequency would be the same for all genes in a given culture.

Accepted Answer

A) True 
 B)False

Exam 19: Gene Mutation and DNA Repair

Which of the following are examples of suppressor mutations?

The Ames test may be used to determine if an agent is a mutagen.

The complete loss of either a guanine or adenine from DNA is an example of ________.

How does position effect influence gene expression?

Reverse mutations involve changing a wild-type allele to a mutant allele.

Ethyl methanesulfonate (EMS)is an example of a deaminating agent.

Which of the following integrate into the double-helix of DNA,interfering with DNA replication?

If a point mutation increases the number of offspring an organism can produce,it would be called a ________ mutation.

Breakpoints in chromosome can lead to mutant phenotypes when they occur in the middle of a gene.

Which environmental agent shown can induce mutations?

When guanine is oxidized into 8-oxoguanine,it will base pair with adenine during DNA replication,causing a transversion mutation.

Mutations that change the configuration of a protein at a specific temperature are called ________ mutations.

Which of the following is an example of a base analog?

Somatic cells are those that give rise to sperm and egg cells.

The wild-type eye color of Drosophila is red.A single-base mutation occurs that produces a white eye color.Which of the following is correct regarding this mutation?

Which repair process can use an enzyme called photolyase?

After screening a colony of bacteria for a given gene,you discover 100 mutant colonies out of 3 million total colonies.What is the mutation frequency for this gene in the population?

Homologous recombination repair requires the presence of a sister chromatid.

The mutation frequency would be the same for all genes in a given culture.

Overview of Genetics

Reproduction and Chromosome Transmission

Mendelian Inheritance

Sex Determination and Sex Chromosomes

Extensions of Mendelian Inheritance

Extranuclear Inheritance, Imprinting, and Maternal Effect

Genetic Linkage and Mapping in Eukaryotes

Variation in Chromosome Structure and Number

Genetics in Bacteria

Genetics of Viruses

Molecular Structure of DNA and RNA

Molecular Structure of Chromosomes and Transposition

Dna Replication and Recombination

Gene Transcription and RNA Modification

Translation of MRNA

Gene Regulation in Bacteria

Gene Regulation in Eukaryotes

Non-Coding Rnas

Molecular Technologies

Genomics

Medical Genetics and Cancer

Population Genetics

Quantitative Genetics

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