Question 1

Sickle cell trait may provide protection against the lethal form of malaria.

Accepted Answer

A) True 
 B)False

Question 2

Which vitamin improves the absorption of oral iron taken to treat iron deficiency anemia in children?

Accepted Answer

A)  Vitamin A 
B)  Vitamin B 
C)  Vitamin C 
D)  Vitamin E 
A)  Vitamin A 
B)  Vitamin B 
C)  Vitamin C 
D)  Vitamin E

Question 3

Hemophilia B is caused by clotting factor _____ deficiency.

Accepted Answer

A)  V 
B)  VIII 
C)  IX 
D)  X 
A)  V 
B)  VIII 
C)  IX 
D)  X

Question 4

Match the type of hemophilia with its characteristics.(Terms can be used more than once. )
-Caused by clotting factor XI deficiency and an autosomal recessive trait

Accepted Answer

A) Hemophilia A 
B) Hemophilia B 
C) Hemophilia C 
D) von Willebrand disease 
A) Hemophilia A 
B) Hemophilia B 
C) Hemophilia C 
D) von Willebrand disease

Question 5

How is glucose 6-phosphate dehydrogenase (G-6-PD)inherited?

Accepted Answer

A)  As an X-linked dominant disorder 
B)  As an X-linked recessive disorder 
C)  As an autosomal dominant disorder 
D)  As an autosomal recessive disorder 
A)  As an X-linked dominant disorder 
B)  As an X-linked recessive disorder 
C)  As an autosomal dominant disorder 
D)  As an autosomal recessive disorder

Question 6

Which disorder results in decreased erythrocytes and platelets with changes in leukocytes and has clinical manifestations of pallor,fatigue,petechiae,purpura,bleeding,and fever?

Accepted Answer

A)  Idiopathic thrombocytopenic purpura (ITP) 
B)  Acute lymphocytic leukemia (ALL) 
C)  Non-Hodgkin lymphoma (NHL) 
D)  Iron deficiency anemia (ID
A)  
A)  Idiopathic thrombocytopenic purpura (ITP) 
B)  Acute lymphocytic leukemia (ALL) 
C)  Non-Hodgkin lymphoma (NHL) 
D)  Iron deficiency anemia (ID
A)

Question 7

Rh incompatibility occurs in fewer than 10% of pregnancies and rarely causes hemolytic disease of the newborn in the first incompatible fetus.

Accepted Answer

A) True 
 B)False

Question 8

In a developing embryo,erythrocyte production shifts from the vessel to the liver until the fifth month of gestation when the hematopoiesis begins to occur in the bone marrow.

Accepted Answer

A) True 
 B)False

Question 9

In ß-thalassemia major,most erythroblasts are destroyed in the spleen.

Accepted Answer

A) True 
 B)False

Question 10

Which kind of anemia is occurs in thalassemia?

Accepted Answer

A)  Microcytic,hypochromic 
B)  Microcytic,normochromic 
C)  Macrocytic,hyperchromic 
D)  Macrocytic,normochromic 
A)  Microcytic,hypochromic 
B)  Microcytic,normochromic 
C)  Macrocytic,hyperchromic 
D)  Macrocytic,normochromic

Question 11

Sickled erythrocytes (characteristic of sickle cell anemia)are stiff and cannot change shape as easily as normal erythrocytes and thus tend to plug the microcirculation.

Accepted Answer

A) True 
 B)False

Question 12

Hemolytic disease of the newborn can occur if:

Accepted Answer

A)  the mother is Rh-positive and the fetus is Rh-negative. 
B)  the mother is Rh-negative and the fetus is Rh-positive. 
C)  the mother has type A blood and the fetus has type O. 
D) the mother has type AB blood and the fetus has type B. 
A)  the mother is Rh-positive and the fetus is Rh-negative. 
B)  the mother is Rh-negative and the fetus is Rh-positive. 
C)  the mother has type A blood and the fetus has type O. 
D) the mother has type AB blood and the fetus has type B.

Question 13

Fetuses who do not survive anemia in utero are usually stillborn,with gross edema of the entire body,a condition called:

Accepted Answer

A)  spherocytosis. 
B)  icterus gravis neonatorum. 
C)  erythroblastosis fetalis. 
D)  hydrops fetalis. 
A)  spherocytosis. 
B)  icterus gravis neonatorum. 
C)  erythroblastosis fetalis. 
D)  hydrops fetalis.

Question 14

MATCHING
Match the sickle cell crises with its description.(Terms can be used more than once. )
-Large amounts of blood become acutely pooled in the liver and spleen

Accepted Answer

A) Vaso-occlusive crisis 
B) Aplastic crisis 
C) Sequestration crisis 
D) Hyperhemolytic crisis 
A) Vaso-occlusive crisis 
B) Aplastic crisis 
C) Sequestration crisis 
D) Hyperhemolytic crisis

Question 15

In a full-term infant,the normal erythrocyte life span is _____ days,while the adult is _____ days.

Accepted Answer

A)  30 to 50;80 
B)  60 to 80;120 
C)  90 to 110;140 
D)  120 to 130;150 
A)  30 to 50;80 
B)  60 to 80;120 
C)  90 to 110;140 
D)  120 to 130;150

Question 16

What does glucose 6-phosphate dehydrogenase (G-6-PD)have in common with sickle cell disease?

Accepted Answer

A)  Both are inherited X-linked recessive disorders. 
B)  Both are inherited autosomal recessive disorders. 
C)  Both disorders are initiated by hypoxemia and acidosis. 
D)  Both occur equally in males and females. 
A)  Both are inherited X-linked recessive disorders. 
B)  Both are inherited autosomal recessive disorders. 
C)  Both disorders are initiated by hypoxemia and acidosis. 
D)  Both occur equally in males and females.

Question 17

An infant's hemoglobin must fall below ___ g/dl before signs of pallor,anoxia,tachycardia,and systolic murmurs occur.

Accepted Answer

A)  11 
B)  9 
C)  7 
D)  5 
A)  11 
B)  9 
C)  7 
D)  5

Question 18

What are the manifestations of chronic sickle cell disease in children?

Accepted Answer

A)  Atelectasis and pneumonia 
B)  Edema of the hands and feet 
C)  Stasis ulcers of the hands,ankles,and feet 
D)  Splenomegaly and hepatomegaly 
A)  Atelectasis and pneumonia 
B)  Edema of the hands and feet 
C)  Stasis ulcers of the hands,ankles,and feet 
D)  Splenomegaly and hepatomegaly

Question 19

Why does fetal hemoglobin have a greater affinity for oxygen than adult hemoglobin?

Accepted Answer

A)  Because the fetus does not have its own oxygen supply and must reply on oxygen from the maternal vascular system 
B)  Because the fetus has two-chains on the hemoglobin,rather than two ß-chains as in the adult 
C)  Because fetal hemoglobin interacts less readily with 2,3 diphosphoglycerate (2,3 DP),which inhibits hemoglobin-oxygen binding 
D)  Because fetal hemoglobin production occurs in the vessels and liver rather than in the bone marrow as in the adult 
A)  Because the fetus does not have its own oxygen supply and must reply on oxygen from the maternal vascular system 
B)  Because the fetus has two-chains on the hemoglobin,rather than two ß-chains as in the adult 
C)  Because fetal hemoglobin interacts less readily with 2,3 diphosphoglycerate (2,3 DP),which inhibits hemoglobin-oxygen binding 
D)  Because fetal hemoglobin production occurs in the vessels and liver rather than in the bone marrow as in the adult

Question 20

_____ is an autosomal dominant inherited hemorrhagic disease.

Accepted Answer

A)  Hemophilia A 
B)  von Willebrand disease 
C)  Christmas disease 
D)  Hemophilia B 
A)  Hemophilia A 
B)  von Willebrand disease 
C)  Christmas disease 
D)  Hemophilia B

Exam 27: Alterations in Hematologic Function in Children

Sickle cell trait may provide protection against the lethal form of malaria.

Which vitamin improves the absorption of oral iron taken to treat iron deficiency anemia in children?

Hemophilia B is caused by clotting factor _____ deficiency.

Match the type of hemophilia with its characteristics.(Terms can be used more than once. ) -Caused by clotting factor XI deficiency and an autosomal recessive trait

How is glucose 6-phosphate dehydrogenase (G-6-PD)inherited?

Which disorder results in decreased erythrocytes and platelets with changes in leukocytes and has clinical manifestations of pallor,fatigue,petechiae,purpura,bleeding,and fever?

Rh incompatibility occurs in fewer than 10% of pregnancies and rarely causes hemolytic disease of the newborn in the first incompatible fetus.

In a developing embryo,erythrocyte production shifts from the vessel to the liver until the fifth month of gestation when the hematopoiesis begins to occur in the bone marrow.

In ß-thalassemia major,most erythroblasts are destroyed in the spleen.

Which kind of anemia is occurs in thalassemia?

Sickled erythrocytes (characteristic of sickle cell anemia)are stiff and cannot change shape as easily as normal erythrocytes and thus tend to plug the microcirculation.

Hemolytic disease of the newborn can occur if:

Fetuses who do not survive anemia in utero are usually stillborn,with gross edema of the entire body,a condition called:

MATCHING Match the sickle cell crises with its description.(Terms can be used more than once. ) -Large amounts of blood become acutely pooled in the liver and spleen

In a full-term infant,the normal erythrocyte life span is _____ days,while the adult is _____ days.

What does glucose 6-phosphate dehydrogenase (G-6-PD)have in common with sickle cell disease?

An infant's hemoglobin must fall below ___ g/dl before signs of pallor,anoxia,tachycardia,and systolic murmurs occur.

What are the manifestations of chronic sickle cell disease in children?

Why does fetal hemoglobin have a greater affinity for oxygen than adult hemoglobin?

_____ is an autosomal dominant inherited hemorrhagic disease.

Cellular Biology

Altered Cellular and Tissue Biology

The Cellular Environment

Genes and Genetic Diseases

Genes, Environment-Lifestyle, and Common Diseases

Innate Immunity Including Inflammation

Adaptive Immunity

Alterations in Immunity and Inflammation Including Hypersensitivies

Infection Including Hivaids

Stress and Disease

Biology of Cancer

Tumor Invasion and Metastasis

Cancer in Children

Structure and Function of the Neurologic System

Pain, Temperature Regulation, Sleep, and Sensory Function

Concepts of Neurologic Dysfunction

Disorders of Neurologic Function

Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders

Alterations of Neurologic Function in Children

Mechanisms of Hormonal Regulation

Alterations of Hormonal Regulation

Structure and Function of the Reproductive Systems

Alterations of the Reproductive Systems

Sexually Transmitted Infections

Structure and Function of the Hematologic System

Alterations of Erythrocyte Function

Structure and Function of the Cardiovascular and Lymphatic Systems

Alterations of Cardiovascular Function

Alterations of Cardiovascular Function in Children

Structure and Function of the Pulmonary System

Alterations of Pulmonary Function

Structure and Function of the Renal and Urologic Systems

Alterations of Renal and Urinary Tract Function

Alterations of Renal and Urinary Tract Function in Children

Structure and Function of the Digestive System

Alterations of Digestive Function

Alterations of Digestive Function in Children

Structure and Function of the Musculoskeletal System

Alterations of Musculoskeletal Function

Alterations of Musculoskeletal Function in Children

Structure, Function, and Disorders of the Integument

Alterations of the Integument in Children

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

Alterations of Leukocyte, Lymphoid, and Hemostatic Function

Alterations of Pulmonary Function in Children

Filters

In a full-term infant,the normal erythrocyte life span is _ days,while the adult is _ days.