Question 1

What prevents kernicterus?

Accepted Answer

A)  Administration of intravenous fluids to dilute the blood and remove the bilirubin through the kidneys faster 
B)  Replacement transfusion of Rh-positive erythrocytes to prevent the deposit of bilirubin in the kidneys 
C)  Performance of a splenectomy to prevent the destruction of abnormal erythrocytes 
D)  Replacement transfusion of Rh-negative erythrocytes to prevent the deposit of bilirubin in the brain 
A)  Administration of intravenous fluids to dilute the blood and remove the bilirubin through the kidneys faster 
B)  Replacement transfusion of Rh-positive erythrocytes to prevent the deposit of bilirubin in the kidneys 
C)  Performance of a splenectomy to prevent the destruction of abnormal erythrocytes 
D)  Replacement transfusion of Rh-negative erythrocytes to prevent the deposit of bilirubin in the brain

Question 2

MATCHING
Match the sickle cell crises with its description.(Terms can be used more than once. )
-Vasospasm occurs,halting blood flow through vessels

Accepted Answer

A) Vaso-occlusive crisis 
B) Aplastic crisis 
C) Sequestration crisis 
D) Hyperhemolytic crisis 
A) Vaso-occlusive crisis 
B) Aplastic crisis 
C) Sequestration crisis 
D) Hyperhemolytic crisis

Question 3

Sickle cell crisis can be prevented by avoiding fever,infection,acidosis,dehydration,constricting clothing,and exposure to cold.

Accepted Answer

A) True 
 B)False

Question 4

Match the type of hemophilia with its characteristics.(Terms can be used more than once. )
-Caused by clotting factor VIII deficiency and an autosomal dominant trait

Accepted Answer

A) Hemophilia A 
B) Hemophilia B 
C) Hemophilia C 
D) von Willebrand disease 
A) Hemophilia A 
B) Hemophilia B 
C) Hemophilia C 
D) von Willebrand disease

Question 5

What is the life span of an erythrocyte in sickle cell anemia?

Accepted Answer

A)  10 to 20 days 
B)  40 to 60 days 
C)  80 to 100 days 
D)  100 to 120 days 
A)  10 to 20 days 
B)  40 to 60 days 
C)  80 to 100 days 
D)  100 to 120 days

Question 6

The most dramatic form of acquired congenital hemolytic anemia is hemolytic disease of the newborn,also termed erythroblastosis fetalis.

Accepted Answer

A) True 
 B)False

Question 7

MATCHING
Match the sickle cell crises with its description.(Terms can be used more than once. )
-Compensatory erythropoiesis is compromised,thus limiting the number of erythrocytes that are replaced

Accepted Answer

A) Vaso-occlusive crisis 
B) Aplastic crisis 
C) Sequestration crisis 
D) Hyperhemolytic crisis 
A) Vaso-occlusive crisis 
B) Aplastic crisis 
C) Sequestration crisis 
D) Hyperhemolytic crisis

Question 8

Match the type of hemophilia with its characteristics.(Terms can be used more than once. )
-Caused by clotting factor VIII deficiency and an X-linked recessive trait

Accepted Answer

A) Hemophilia A 
B) Hemophilia B 
C) Hemophilia C 
D) von Willebrand disease 
A) Hemophilia A 
B) Hemophilia B 
C) Hemophilia C 
D) von Willebrand disease

Question 9

Hemophilia A is inherited in an _____ fashion.

Accepted Answer

A)  autosomal dominant 
B)  autosomal recessive 
C)  X-linked recessive 
D)  X-linked dominant 
A)  autosomal dominant 
B)  autosomal recessive 
C)  X-linked recessive 
D)  X-linked dominant

Question 10

Sickle cell disease is inherited in an _____ fashion.

Accepted Answer

A)  autosomal dominant 
B)  autosomal recessive 
C)  X-linked dominant 
D)  X-linked recessive 
A)  autosomal dominant 
B)  autosomal recessive 
C)  X-linked dominant 
D)  X-linked recessive

Question 11

How is hemoglobin S (HbS)formed in sickle cell disease?

Accepted Answer

A)  By a deficiency in glucose 6-phosphate dehydrogenase (G-6-P
D) that changes hemoglobin A to hemoglobin S 
B)  By a genetic mutation in which two amino acids (histidine and leucine)are missing 
C)  By a genetic mutation in which one amino acid (valine)is replaced by another (glutamic acid) 
D)  By an autoimmune response in which one amino acid (proline)is detected as an antigen by abnormal immunoglobulin G (IgG) 
A)  By a deficiency in glucose 6-phosphate dehydrogenase (G-6-P
D) that changes hemoglobin A to hemoglobin S 
B)  By a genetic mutation in which two amino acids (histidine and leucine)are missing 
C)  By a genetic mutation in which one amino acid (valine)is replaced by another (glutamic acid) 
D)  By an autoimmune response in which one amino acid (proline)is detected as an antigen by abnormal immunoglobulin G (IgG)

Exam 27: Alterations in Hematologic Function in Children

What prevents kernicterus?

MATCHING Match the sickle cell crises with its description.(Terms can be used more than once. ) -Vasospasm occurs,halting blood flow through vessels

Sickle cell crisis can be prevented by avoiding fever,infection,acidosis,dehydration,constricting clothing,and exposure to cold.

Match the type of hemophilia with its characteristics.(Terms can be used more than once. ) -Caused by clotting factor VIII deficiency and an autosomal dominant trait

What is the life span of an erythrocyte in sickle cell anemia?

The most dramatic form of acquired congenital hemolytic anemia is hemolytic disease of the newborn,also termed erythroblastosis fetalis.

MATCHING Match the sickle cell crises with its description.(Terms can be used more than once. ) -Compensatory erythropoiesis is compromised,thus limiting the number of erythrocytes that are replaced

Match the type of hemophilia with its characteristics.(Terms can be used more than once. ) -Caused by clotting factor VIII deficiency and an X-linked recessive trait

Hemophilia A is inherited in an _____ fashion.

Sickle cell disease is inherited in an _____ fashion.

How is hemoglobin S (HbS)formed in sickle cell disease?

Cellular Biology

Altered Cellular and Tissue Biology

The Cellular Environment

Genes and Genetic Diseases

Genes, Environment-Lifestyle, and Common Diseases

Innate Immunity Including Inflammation

Adaptive Immunity

Alterations in Immunity and Inflammation Including Hypersensitivies

Infection Including Hivaids

Stress and Disease

Biology of Cancer

Tumor Invasion and Metastasis

Cancer in Children

Structure and Function of the Neurologic System

Pain, Temperature Regulation, Sleep, and Sensory Function

Concepts of Neurologic Dysfunction

Disorders of Neurologic Function

Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders

Alterations of Neurologic Function in Children

Mechanisms of Hormonal Regulation

Alterations of Hormonal Regulation

Structure and Function of the Reproductive Systems

Alterations of the Reproductive Systems

Sexually Transmitted Infections

Structure and Function of the Hematologic System

Alterations of Erythrocyte Function

Structure and Function of the Cardiovascular and Lymphatic Systems

Alterations of Cardiovascular Function

Alterations of Cardiovascular Function in Children

Structure and Function of the Pulmonary System

Alterations of Pulmonary Function

Structure and Function of the Renal and Urologic Systems

Alterations of Renal and Urinary Tract Function

Alterations of Renal and Urinary Tract Function in Children

Structure and Function of the Digestive System

Alterations of Digestive Function

Alterations of Digestive Function in Children

Structure and Function of the Musculoskeletal System

Alterations of Musculoskeletal Function

Alterations of Musculoskeletal Function in Children

Structure, Function, and Disorders of the Integument

Alterations of the Integument in Children

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

Alterations of Leukocyte, Lymphoid, and Hemostatic Function

Alterations of Pulmonary Function in Children

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