Question 1

Draw the most stable enol of the following ketone.

Accepted Answer

The answer of Draw the most stable enol of the...

Question 2

How would you accomplish the following conversion?

Accepted Answer

A) H+/H2O; HC   N 
B) (-OH/NaC   N) 
C) Br2/H+,H2O; NaC   N 
D) HBr; NaC   N 
E) LiAlH4; HC   N; KMnO4 
A) H+/H2O; HC   N 
B) (-OH/NaC   N) 
C) Br2/H+,H2O; NaC   N 
D) HBr; NaC   N 
E) LiAlH4; HC   N; KMnO4

Question 3

What product is formed in the mixed Claisen condensation between methyl benzoate and cyclohexanone?

Accepted Answer

The answer of What product is formed in the mixed...

Question 4

Give the major product for the following reaction.

Accepted Answer

The answer of Give the major product for the following...

Question 5

Which of the labeled hydrogen atoms in the following structure is the most acidic?

Accepted Answer

A) 1 
B) 2 
C) 3 
D) 4 
E) 5 
A) 1 
B) 2 
C) 3 
D) 4 
E) 5

Question 6

Fill in the empty boxes.

Accepted Answer

The answer of Fill in the empty boxes.  ...

Question 7

Give the major product for the following reaction.

Accepted Answer

A)    
B)    
C)    
D)    
E)    
A)    
B)    
C)    
D)    
E)

Question 8

Provide the major organic product(s)of the reaction shown below.

Accepted Answer

The answer of Provide the major organic product(s)of the reaction...

Question 9

Why is the pKa of acetone 20 while that of ethane is 50? Explain the origin for this difference in acidity.

Accepted Answer

When a proton is removed from ethane,the

Question 10

Give the major product for the following reaction.

Accepted Answer

A)    
B)    
C)    
D)    
E) no reaction 
A)    
B)    
C)    
D)    
E) no reaction

Question 11

What two starting materials yield OHCCH2CO2CH2CH3 as the mixed Claisen condensation product?

Accepted Answer

HCO₂CH₂CH₃ an

Question 12

Give the major product for the reaction.

Accepted Answer

A)    
B)    
C)    
D)    
E)    
A)    
B)    
C)    
D)    
E)

Question 13

What is the major organic product of the following reaction?

Accepted Answer

A) I 
B) II 
C) III 
D) IV 
E) V 
A) I 
B) II 
C) III 
D) IV 
E) V

Question 14

List the following carbonyl compounds in order of decreasing pKa: 2,4-pentanedione,diethyl malonate,propanal,ethyl acetate.

Accepted Answer

ethyl acetate > prop

Question 15

An α,β-unsaturated ketone is a product in which of the following reactions?

Accepted Answer

A) Aldol condensation 
B) Claisen condensation 
C) Diekmann condensation 
D) Robinson annulation 
E) Michael addition 
A) Aldol condensation 
B) Claisen condensation 
C) Diekmann condensation 
D) Robinson annulation 
E) Michael addition

Question 16

Enolates are frequently formed by treating an aldehyde or ketone with LDA.However,the LDA must first be generated by reacting diisopropylamine with butyllithium.Why don't chemists just use butyllithium itself to deprotonate the aldehyde or ketone and form the enolate?

Accepted Answer

Butyllithium is a strong enough base but

Question 17

Give the major product for the following reaction.

Accepted Answer

A)    
B)    
C)    
D)    
E)    
A)    
B)    
C)    
D)    
E)

Question 18

Provide the major organic product of the following.

Accepted Answer

The answer of Provide the major organic product of the...

Question 19

Provide the structure of the major organic product which results when PhCO2CH2CH3 and CH3CH2CO2CH2CH3 are heated in the presence of sodium ethoxide and the compound generated is subsequently treated with cold,dilute acid.

Accepted Answer

Question 20

Give the major product of the following reaction.

Accepted Answer

The answer of Give the major product of the following...

Exam 17: Reactions at the Α-Carbon

Draw the most stable enol of the following ketone.

How would you accomplish the following conversion?

What product is formed in the mixed Claisen condensation between methyl benzoate and cyclohexanone?

Give the major product for the following reaction.

Which of the labeled hydrogen atoms in the following structure is the most acidic?

Fill in the empty boxes.

Give the major product for the following reaction.

Provide the major organic product(s)of the reaction shown below.

Why is the pKa of acetone 20 while that of ethane is 50? Explain the origin for this difference in acidity.

Give the major product for the following reaction.

What two starting materials yield OHCCH2CO2CH2CH3 as the mixed Claisen condensation product?

Give the major product for the reaction.

What is the major organic product of the following reaction?

List the following carbonyl compounds in order of decreasing pKa: 2,4-pentanedione,diethyl malonate,propanal,ethyl acetate.

An α,β-unsaturated ketone is a product in which of the following reactions?

Enolates are frequently formed by treating an aldehyde or ketone with LDA.However,the LDA must first be generated by reacting diisopropylamine with butyllithium.Why don't chemists just use butyllithium itself to deprotonate the aldehyde or ketone and form the enolate?

Give the major product for the following reaction.

Provide the major organic product of the following.

Provide the structure of the major organic product which results when PhCO2CH2CH3 and CH3CH2CO2CH2CH3 are heated in the presence of sodium ethoxide and the compound generated is subsequently treated with cold,dilute acid.

Give the major product of the following reaction.

Remembering General Chemistry: Electronic Structure and Bonding

Acids and Bases: Central to Understanding Organic Chemistry

An Introduction to Organic Compounds: Nomenclature, physical Properties, and Structure

Isomers: the Arrangement of Atoms in Space

Alkenes: Structure,nomenclature,and an Introduction to Reactivity - Thermodynamics and Kinetics

The Reactions of Alkenes - the Stereochemistry of Addition Reactions

The Reactions of Alkynes - Introduction to Multistep Synthesis

Delocalized Electrons: Their Effect on Stability, pka, and the Products of a Reaction - Aromaticity and Electronic Effects: an Introduction to the Reactions of Benzene

Substitution and Elimination Reactions of Alkyl Halides

Reactions of Alcohols, ethers, epoxides, amines and Sulfur-Containing Compounds

Organometallic Compounds

Radicals

Mass Spectrometry,infrared Spectroscopy,and Uvvis Spectroscopy

Nmr Spectroscopy

Reactions of Carboxylic Acids and Carboxylic Acid Derivatives

Reactions of Aldehydes and Ketones

Reactions of Benzene and Substituted Benzenes

More About Amines - Reactions of Heterocylic Compounds

The Organic Chemistry of Carbohydrates

Amino Acids,peptides,and Proteins

Catalysis in Organic Reactions and in Enzymatic Reactions

The Organic Chemistry of the Coenzymes, compounds Derived From Vitamins

The Organic Chemistry of the Metabolic Pathways

The Organic Chemistry of Lipids

The Chemistry of the Nucleic Acids

Synthetic Polymers

Pericyclic Reactions

Filters

What two starting materials yield OHCCH₂CO₂CH₂CH₃ as the mixed Claisen condensation product?

Provide the structure of the major organic product which results when PhCO₂CH₂CH₃ and CH₃CH₂CO₂CH₂CH₃ are heated in the presence of sodium ethoxide and the compound generated is subsequently treated with cold,dilute acid.