Question 1

Which of the following is involved in connecting the centromere to the spindles during chromosome segregation in mitosis?

Accepted Answer

A)  Kinetochore 
B)  Euchromatin 
C)  Histone protein H1 
D)  Heterochromatin 
A)  Kinetochore 
B)  Euchromatin 
C)  Histone protein H1 
D)  Heterochromatin

Question 2

An exchange of genetic material between chromosomes is called a(n):

Accepted Answer

A)  Deletion 
B)  Inversion 
C)  Insertion 
D)  Translocation 
A)  Deletion 
B)  Inversion 
C)  Insertion 
D)  Translocation

Question 3

How is high-resolution banding achieved?

Accepted Answer

A)  Increase the concentration of Giemsa. 
B)  Stain the chromosomes longer. 
C)  Stain the chromosomes at low temperatures. 
D)  Stain the chromosomes before maximal condensation. 
A)  Increase the concentration of Giemsa. 
B)  Stain the chromosomes longer. 
C)  Stain the chromosomes at low temperatures. 
D)  Stain the chromosomes before maximal condensation.

Question 4

Chromosomes are divided into different parts, and locations are denoted by numbers corresponding to the different parts in which of the following orders?

Accepted Answer

A)  Sub-band, band, chromosome, region 
B)  Region, band, sub-band, chromosome 
C)  Band, chromosome, region, sub-band 
D)  Chromosome, region, band, sub-band 
A)  Sub-band, band, chromosome, region 
B)  Region, band, sub-band, chromosome 
C)  Band, chromosome, region, sub-band 
D)  Chromosome, region, band, sub-band

Question 5

A polymorphism is distinguished from a mutation in what way?

Accepted Answer

A)  Its frequency in a given population 
B)  The size of the genetic region involved 
C)  The severity of effect on phenotype 
D)  Associations with other genetic events 
A)  Its frequency in a given population 
B)  The size of the genetic region involved 
C)  The severity of effect on phenotype 
D)  Associations with other genetic events

Question 6

In spectral karyotyping, each of the 23 chromosomes is distinguished by:

Accepted Answer

A)  Size 
B)  Degree of staining 
C)  Fluorescent color 
D)  Position 
A)  Size 
B)  Degree of staining 
C)  Fluorescent color 
D)  Position

Question 7

Which of the following is an advantage of interphase FISH as compared with metaphase FISH?

Accepted Answer

A)  Examination of 20 spreads in interphase FISH has increased sensitivity. 
B)  One can identify mutations anywhere in the chromosome in interphase FISH. 
C)  Interphase FISH allows identification of all chromosomes. 
D)  Results are available faster in interphase FISH procedures than metaphase FISH procedures. 
A)  Examination of 20 spreads in interphase FISH has increased sensitivity. 
B)  One can identify mutations anywhere in the chromosome in interphase FISH. 
C)  Interphase FISH allows identification of all chromosomes. 
D)  Results are available faster in interphase FISH procedures than metaphase FISH procedures.

Question 8

A chromosome formed when parts of two or more chromosomes are joined to a third normal chromosome is called a(n):

Accepted Answer

A)  Ring chromosome 
B)  Isochromosome 
C)  Derivative chromosome 
D)  Balanced translocation 
A)  Ring chromosome 
B)  Isochromosome 
C)  Derivative chromosome 
D)  Balanced translocation

Question 9

A change in DNA sequence that is present in at least 1% to 2% of the population is called a(n):

Accepted Answer

A)  Phenotype 
B)  Polymorphism 
C)  Aneuploid 
D)  Mutation 
A)  Phenotype 
B)  Polymorphism 
C)  Aneuploid 
D)  Mutation

Question 10

The karyotype of a normal male is designated by which of the following?

Accepted Answer

A)  46, XX 
B)  46, XY 
C)  47, XX 
D)  47, XY 
A)  46, XX 
B)  46, XY 
C)  47, XX 
D)  47, XY

Which of the following is involved in connecting the centromere to the spindles during chromosome segregation in mitosis?

An exchange of genetic material between chromosomes is called a(n):

How is high-resolution banding achieved?

Chromosomes are divided into different parts, and locations are denoted by numbers corresponding to the different parts in which of the following orders?

A polymorphism is distinguished from a mutation in what way?

In spectral karyotyping, each of the 23 chromosomes is distinguished by:

Which of the following is an advantage of interphase FISH as compared with metaphase FISH?

A chromosome formed when parts of two or more chromosomes are joined to a third normal chromosome is called a(n):

A change in DNA sequence that is present in at least 1% to 2% of the population is called a(n):

The karyotype of a normal male is designated by which of the following?

DNA

RNA

Proteins

Nucleic Acid Extraction Methods

Resolution and Detection of Nucleic Acids

Analysis and Characterization of Nucleic Acids and Proteins

Nucleic Acid Amplification

Gene Mutations

DNA Sequencing

DNA Polymorphisms and Human Identification

Detection and Identification of Microorganisms

Molecular Detection of Inherited Diseases

Molecular Oncology

DNA-Based Tissue Typing

Quality Assurance and Quality Control in the Molecular Laboratory

Filters

Exam 8: Chromosomal Structure and Chromosomal Mutations

Which of the following is involved in connecting the centromere to the spindles during chromosome segregation in mitosis?

An exchange of genetic material between chromosomes is called a(n):

How is high-resolution banding achieved?

Chromosomes are divided into different parts, and locations are denoted by numbers corresponding to the different parts in which of the following orders?

A polymorphism is distinguished from a mutation in what way?

In spectral karyotyping, each of the 23 chromosomes is distinguished by:

Which of the following is an advantage of interphase FISH as compared with metaphase FISH?

A chromosome formed when parts of two or more chromosomes are joined to a third normal chromosome is called a(n):

A change in DNA sequence that is present in at least 1% to 2% of the population is called a(n):

The karyotype of a normal male is designated by which of the following?

DNA

RNA

Proteins

Nucleic Acid Extraction Methods

Resolution and Detection of Nucleic Acids

Analysis and Characterization of Nucleic Acids and Proteins

Nucleic Acid Amplification

Gene Mutations

DNA Sequencing

DNA Polymorphisms and Human Identification

Detection and Identification of Microorganisms

Molecular Detection of Inherited Diseases

Molecular Oncology

DNA-Based Tissue Typing

Quality Assurance and Quality Control in the Molecular Laboratory

Filters