Question 1

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once.
-Gold salts

Accepted Answer

A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain 
A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain

Question 2

A patient has taken NSAIDs for an extended period of time for the treatment of RA.What presenting symptoms most appropriately indicate the patient may have hepatic failure?

Accepted Answer

A) History of black,tarry stools;left lower quadrant pain;and fever 
B) Abdominal skin rashes,pruritis,nail pitting,and decreased capillary refill 
C) Flank pain,urinary frequency,urinary urgency,and hematuria 
D) Right upper quadrant tenderness,fatigue,lethargy,and persistent headaches 
A) History of black,tarry stools;left lower quadrant pain;and fever 
B) Abdominal skin rashes,pruritis,nail pitting,and decreased capillary refill 
C) Flank pain,urinary frequency,urinary urgency,and hematuria 
D) Right upper quadrant tenderness,fatigue,lethargy,and persistent headaches

Question 3

Which gold compound is exclusively utilized for the treatment of juvenile rheumatoid arthritis (JRA)?

Accepted Answer

A) hydroxychloroquine 
B) aurothioglucose suspension 
C) sodium aurothiomalate 
D) infliximab 
A) hydroxychloroquine 
B) aurothioglucose suspension 
C) sodium aurothiomalate 
D) infliximab

Question 4

A 42-year-old male visits the ENT clinic complaining of a 2-week history of tinnitus.Physical examination is negative for infectious or neurological pathology.What important history may explain the patient's symptoms?

Accepted Answer

A) He was diagnosed with cerumen impaction 3 months ago and successfully treated with cerumen softeners and ear flushing. 
B) He was diagnosed with a ruptured tympanic membrane 5 years ago after which his hearing returned to normal. 
C) He began taking etodolac 3 weeks ago for right shoulder pain and swelling. 
D) There is a family history of brain tumors. 
A) He was diagnosed with cerumen impaction 3 months ago and successfully treated with cerumen softeners and ear flushing. 
B) He was diagnosed with a ruptured tympanic membrane 5 years ago after which his hearing returned to normal. 
C) He began taking etodolac 3 weeks ago for right shoulder pain and swelling. 
D) There is a family history of brain tumors.

Question 5

Match the NSAID adverse reaction with the correct signs and symptoms.
-Hepatic failure

Accepted Answer

A) Fatigue,lethargy,pruritus,jaundice,and headache 
B) Black tarry stool,skin rash,edema,and weight gain 
C) Nausea,vomiting,and diaphoresis 
D) Headache,dizziness,tinnitus,and hearing loss 
A) Fatigue,lethargy,pruritus,jaundice,and headache 
B) Black tarry stool,skin rash,edema,and weight gain 
C) Nausea,vomiting,and diaphoresis 
D) Headache,dizziness,tinnitus,and hearing loss

Question 6

Match the NSAID adverse reaction with the correct signs and symptoms.
-Gastrointestinal ulceration

Accepted Answer

A) Fatigue,lethargy,pruritus,jaundice,and headache 
B) Black tarry stool,skin rash,edema,and weight gain 
C) Nausea,vomiting,and diaphoresis 
D) Headache,dizziness,tinnitus,and hearing loss 
A) Fatigue,lethargy,pruritus,jaundice,and headache 
B) Black tarry stool,skin rash,edema,and weight gain 
C) Nausea,vomiting,and diaphoresis 
D) Headache,dizziness,tinnitus,and hearing loss

Question 7

A 55-year-old female patient is referred to a rheumatologist after being diagnosed with RA by her primary care physician 3 months ago.She was initially prescribed ketoprofen.She is referred due to no improvement in her symptoms.What is the most appropriate pharmacologic agent to add to the patient's regimen?

Accepted Answer

A) corticosteroid 
B) etanercept (Enbrel) 
C) acetaminophen 
D) oxycodone (Percocet) 
A) corticosteroid 
B) etanercept (Enbrel) 
C) acetaminophen 
D) oxycodone (Percocet)

Question 8

Match the therapeutic agent with its correct mechanism of action.Mechanism of actions may be used more than once.
-allopurinol (Zyloprim)

Accepted Answer

A) Enzyme xanthine oxidase inhibitor 
B) Plant alkaloid believed to interfere with leukocyte function 
C) Inhibits renal tubular absorption of uric acid 
A) Enzyme xanthine oxidase inhibitor 
B) Plant alkaloid believed to interfere with leukocyte function 
C) Inhibits renal tubular absorption of uric acid

Question 9

Which agent used to treat hyperuricemia also increases circulating levels of antibiotics?

Accepted Answer

A) probenecid (Benemid) 
B) colchicine 
C) allopurinol (Zyloprim) 
D) sulfinpyrazone (Anturane) 
A) probenecid (Benemid) 
B) colchicine 
C) allopurinol (Zyloprim) 
D) sulfinpyrazone (Anturane)

Question 10

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once.
-DMARDs

Accepted Answer

A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain 
A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain

Question 11

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once.
-colchicine

Accepted Answer

A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain 
A) Improved joint mobility and function 
B) Treatment of gout 
C) Prescribed for pain

Question 12

Salicylism is common among those who self-medicate with any drug in the NSAID class.Which of the following is not a common presenting symptom of salicylism?

Accepted Answer

A) Headache 
B) Dizziness 
C) Thirst 
D) Hypoventilation 
E) Nausea 
A) Headache 
B) Dizziness 
C) Thirst 
D) Hypoventilation 
E) Nausea

Question 13

A 36-year-old woman is diagnosed with RA.She is a stay-at-home mother of two school-age children.She begins a treatment protocol that includes anakinra 100 mg SQ once daily.What additional therapeutic intervention is least relevant to her pathology management?

Accepted Answer

A) Avoidance of infections 
B) Physical therapy 
C) Exercise 
D) Rest 
E) Hydration 
A) Avoidance of infections 
B) Physical therapy 
C) Exercise 
D) Rest 
E) Hydration

Question 14

COX-1-inhibiting NSAIDs result in adverse effects on the gastrointestinal tract.What causes this adverse effect?

Accepted Answer

A) COX-1 regulates gastric acid secretion. 
B) COX-1 inhibits the synthesis of prostaglandins. 
C) COX-1 regulates endothelial cells in the kidney. 
D) COX-1 promotes the secretion of histamine. 
A) COX-1 regulates gastric acid secretion. 
B) COX-1 inhibits the synthesis of prostaglandins. 
C) COX-1 regulates endothelial cells in the kidney. 
D) COX-1 promotes the secretion of histamine.

Question 15

Inflammation in the body leads to cell membrane destruction and the release of chemical mediators.What enzyme is necessary in order to produce these mediators?

Accepted Answer

A) Lipo-oxygenase 
B) Cytokine 
C) Histamine 
D) Prostaglandin 
E) Leukotriene 
A) Lipo-oxygenase 
B) Cytokine 
C) Histamine 
D) Prostaglandin 
E) Leukotriene

Question 16

What is the most appropriate situation in which corticosteroids can be used in conscientious prescribing of DMARDs?

Accepted Answer

A) Late in treatment to provide symptomatic relief when biologic DMARDs fail 
B) In high doses for patients who fail to get adequate response from a DMARD 
C) In bursts to treat acute flares of disease 
D) If adequate response was achieved by a biologic DMARD 
A) Late in treatment to provide symptomatic relief when biologic DMARDs fail 
B) In high doses for patients who fail to get adequate response from a DMARD 
C) In bursts to treat acute flares of disease 
D) If adequate response was achieved by a biologic DMARD

Question 17

Although gold salts have been utilized for the treatment of inflammation for more than 65 years,why are they currently agents of last resort-reserved for those patients who do not respond to anything else?

Accepted Answer

A) Gold salts are slow acting. 
B) Gold salts are less toxic than DMARDs. 
C) Gold salts are an older and less expensive drug. 
D) Gold salts require regular urine protein monitoring. 
A) Gold salts are slow acting. 
B) Gold salts are less toxic than DMARDs. 
C) Gold salts are an older and less expensive drug. 
D) Gold salts require regular urine protein monitoring.

Question 18

Match the drug with its correct mechanism of action.
-hydroxyychloroquine (Plaquenil)

Accepted Answer

A) Decreases the T-cell response to mitogens 
B) Chimeric monoclonal antibody 
C) Alters cellular mechanisms such as collagen biosynthesis 
D) Folate antimetabolite that inhibits DNA synthesis 
E) Triggers p53 translocation,inhibiting pyrimidine 
A) Decreases the T-cell response to mitogens 
B) Chimeric monoclonal antibody 
C) Alters cellular mechanisms such as collagen biosynthesis 
D) Folate antimetabolite that inhibits DNA synthesis 
E) Triggers p53 translocation,inhibiting pyrimidine

Question 19

Match the therapeutic agent with its correct mechanism of action.Mechanism of actions may be used more than once.
-probenecid (Benemid)

Accepted Answer

A) Enzyme xanthine oxidase inhibitor 
B) Plant alkaloid believed to interfere with leukocyte function 
C) Inhibits renal tubular absorption of uric acid 
A) Enzyme xanthine oxidase inhibitor 
B) Plant alkaloid believed to interfere with leukocyte function 
C) Inhibits renal tubular absorption of uric acid

Question 20

Match the drug with its correct mechanism of action.
-auranofin (Ridaura)

Accepted Answer

A) Decreases the T-cell response to mitogens 
B) Chimeric monoclonal antibody 
C) Alters cellular mechanisms such as collagen biosynthesis 
D) Folate antimetabolite that inhibits DNA synthesis 
E) Triggers p53 translocation,inhibiting pyrimidine 
A) Decreases the T-cell response to mitogens 
B) Chimeric monoclonal antibody 
C) Alters cellular mechanisms such as collagen biosynthesis 
D) Folate antimetabolite that inhibits DNA synthesis 
E) Triggers p53 translocation,inhibiting pyrimidine

Exam 4: Drugs Used in the Treatment of Bone and Joint Disorders

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once. -Gold salts

A patient has taken NSAIDs for an extended period of time for the treatment of RA.What presenting symptoms most appropriately indicate the patient may have hepatic failure?

Which gold compound is exclusively utilized for the treatment of juvenile rheumatoid arthritis (JRA)?

A 42-year-old male visits the ENT clinic complaining of a 2-week history of tinnitus.Physical examination is negative for infectious or neurological pathology.What important history may explain the patient's symptoms?

Match the NSAID adverse reaction with the correct signs and symptoms. -Hepatic failure

Match the NSAID adverse reaction with the correct signs and symptoms. -Gastrointestinal ulceration

Match the therapeutic agent with its correct mechanism of action.Mechanism of actions may be used more than once. -allopurinol (Zyloprim)

Which agent used to treat hyperuricemia also increases circulating levels of antibiotics?

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once. -DMARDs

Match the pathology with its correct therapeutic intervention.Pathologies may be used more than once. -colchicine

Salicylism is common among those who self-medicate with any drug in the NSAID class.Which of the following is not a common presenting symptom of salicylism?

A 36-year-old woman is diagnosed with RA.She is a stay-at-home mother of two school-age children.She begins a treatment protocol that includes anakinra 100 mg SQ once daily.What additional therapeutic intervention is least relevant to her pathology management?

COX-1-inhibiting NSAIDs result in adverse effects on the gastrointestinal tract.What causes this adverse effect?

Inflammation in the body leads to cell membrane destruction and the release of chemical mediators.What enzyme is necessary in order to produce these mediators?

What is the most appropriate situation in which corticosteroids can be used in conscientious prescribing of DMARDs?

Although gold salts have been utilized for the treatment of inflammation for more than 65 years,why are they currently agents of last resort-reserved for those patients who do not respond to anything else?

Match the drug with its correct mechanism of action. -hydroxyychloroquine (Plaquenil)

Match the therapeutic agent with its correct mechanism of action.Mechanism of actions may be used more than once. -probenecid (Benemid)

Match the drug with its correct mechanism of action. -auranofin (Ridaura)

Conscientious and Rational Prescribing in the 21st Century

An Introduction to Pharmacodynamics and Pharmacokinetics

Communicating With Patients About Medications: a Patient-Centered Approach

Drugs Used in the Treatment of Eye and Ear Disorders

Drugs Used in the Treatment of Cardiovascular Disorders

Drugs Used to Regulate Blood Pressure

Drugs Used in the Treatment of Hyperlipidemias

Drugs Used in the Treatment of Blood Disorders

Drugs Used in the Treatment of Pulmonary Diseases and Disorders

Drugs Used in the Treatment of Common Disorders of the Gastrointestinal System

Drugs Used to Treat Endocrine Gland Disorders

Drugs Used in the Treatment of Diabetes Mellitus

Drugs Used to Treat Common Neurological Conditions

Practical Pharmacotherapy of Drugs Used to Treat Psychiatric Disorders

Drugs Used in the Treatment of Skin Disorders

Modern Approaches to Managing Bacterial Infections

Drugs Used in the Treatment of Nonbacterial Infections

Drugs Used in the Treatment of Neoplasms

Drugs Used to Affect Womens Health

Drugs Used to Affect Mens Health

Prescribing for the Geriatric Patient

Prescribing for the Pediatric Patient

Drugs Used to Manage Pain

The Integrative Medicine Pharmacopoeia: Herbals, vitamins, and Dietary Supplements

Agents Used to Manipulate the Immune Response

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