Exam 14: Ige-Mediated Immunity and Allergy

All of the following are biological effects mediated by the products of mast cells except _____.

During a primary immune response IgM sometimes switches to IgE.Which of the following best describes the consequence of this early switch?

A.Describe in detail the mechanism responsible for mast-cell activation during a type I hypersensitivity reaction. B.What are the products of mast-cell activation?

The antigens that provoke hypersensitivity reactions are referred to as

Anita Garcia,17 years old,and her roommate Rosa Rosario were celebrating a friend's birthday at a dessert buffet at a local restaurant when Anita developed acute dyspnea,and angioedema.She complained of an itchy rash,and then had difficulty swallowing.Rosa drove Anita to the emergency room two blocks away rather than wait for an ambulance.As they approached the hospital,Anita lost consciousness.This medical emergency would most probably result in immediate _____ before any subsequent treatment.

Which of the following regarding FcεRI is false?

A.Describe two ways in which the immunoglobulins acting as antigen receptors on the surface of a mast cell differ from the immunoglobulins acting as the antigen receptors on the surface of a B cell. B.What is the essential difference in response of these two cell types when antigen binds to these surface immunoglobulins.

Aspirin (acetyl salicylate)inhibits prostaglandin synthesis by binding irreversibly to prostaglandin synthase,the first enzyme in the _____ pathway.

Anita Garcia,17 years old,and her roommate Rosa Rosario were celebrating a friend's birthday at a dessert buffet at a local restaurant when Anita developed acute dyspnea,and angioedema.She complained of an itchy rash,and then had difficulty swallowing.Rosa drove Anita to the emergency room two blocks away rather than wait for an ambulance.As they approached the hospital,Anita lost consciousness -What do you think Anita was suffering from? Given the circumstances in which the episode occurred,suggest a likely cause.

During the course of a successful desensitization process,the patient's antibodies will change from an _____isotype to an _____ isotype.

The sheddase _____ cleaves FcεRII on the cell surface,resulting in the production of monomeric and trimeric forms of FcεRII.

Explain briefly how penicillin initiates a type I hypersensitivity response.

A.Explain how erythrocytes become coated with complement component C3b during an allergic reaction to penicillin. B.Why is this important to the mechanism by which IgE antibodies are produced?

Identify the mismatched pair.

A.Explain the importance of allergens having protease activity in the context of antigen-specific T-cell activation. B.Provide a specific example of a major allergen that has protease activity.

Why are antihistamines used to treat allergic rhinitis and allergic asthma? What symptoms of each disease,respectively,do they alleviate.

Which of the following directly inhibits the cyclooxygenase pathway by inhibiting the activity of prostaglandin synthase?

Give three ways in which a susceptible person can help to minimize the risk of having an allergic reaction.

Which of the following are consequences of anaphylactic shock? (Select all that apply.)