Exam 6: The Development of B Lymphocytes

A defect in which of the following proteins blocks B-cell development at the pre-B-cell stage,resulting in almost no circulating antibodies in individuals with this defect?

Free

(Multiple Choice)

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Question 1

Correct Answer:

Verified

The consequence of allelic exclusion at the immunoglobulin loci ensures that _____.(Select all that apply.)

Free

(Multiple Choice)

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Question 2

Correct Answer:

Verified

B,E

What is the role of primary lymphoid follicles in eliminating B cells that have antigen receptors specific for soluble self antigen?

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(Essay)

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Question 3

Correct Answer:

Verified

To survive,circulating B cells must enter primary follicles where survival signals are delivered by cells in the follicles,including follicular dendritic cells (which are the stromal cells of primary lymphoid follicles).Circulating B cells that fail to enter follicles in secondary lymphoid tissues will die in the peripheral circulation with a half-life of about 3 days.B cells with antigen receptors specific for soluble self antigen are generally rendered anergic in the bone marrow or the circulation.Anergic B cells that enter secondary lymphoid organs are held in the T-cell areas adjacent to primary follicles and are not permitted to penetrate the follicle.As a result,they do not receive the necessary stimulatory signal for survival.Instead,anergic B cells will undergo apoptosis in the T-cell zone.This is an efficient cleansing mechanism and serves to delete potentially autoreactive B cells from the circulation.

Immunological tolerance in the B-cell repertoire is called _ tolerance when it develops in primary lymphoid organs,and _ tolerance when it is induced outside the bone marrow.

(Multiple Choice)

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Question 4

When producing monoclonal antibodies,why is it important to use as a fusion partner a myeloma cell that is unable to produce its own immunoglobulin?

(Multiple Choice)

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Question 5

Describe the six functionally distinct phases of B-cell development.

(Essay)

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Question 6

A developing B cell unable to generate a productive rearrangement on any of the four light-chain loci will undergo

(Multiple Choice)

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Question 7

Which of the following is a characteristic of B-2 cells?

(Multiple Choice)

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Question 8

Which of the following would occur after the production of a functional μ chain as a pre-B-cell receptor?

(Multiple Choice)

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Question 9

Which of the following is correctly matched? (Select all that apply.)

(Multiple Choice)

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Question 10

Indicate which of the following statements concerning memory B cells are true (T)and which are false (F):

Memory B cells are derived from germinal center B cells as immune responses subside. ___

True

Memory B cells have more stringent requirements for activation than naive B cells do.

False

Memory B cells possess high-affinity antigen receptors as a consequence of affinity maturation.

Correct Answer:

Verified

Memory B cells are derived from germinal center B cells as immune responses subside. ___

Memory B cells have more stringent requirements for activation than naive B cells do.

(Matching)

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Question 11

Negative selection of developing B cells ensures that

(Multiple Choice)

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Question 12

An important advantage of having two gene loci (κ and λ)for the light chain is

(Multiple Choice)

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Question 13

The circulatory route through a lymphoid tissue for both immature B cells and mature B cells that do not encounter specific antigen is:

(Multiple Choice)

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Question 14

All hematopoietic stem cells express

(Multiple Choice)

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Question 15

A.Identify properties that are shared by anergic B cells and plasma cells. B.What key property is different?

(Essay)

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Question 16

Large pre-B cells undergo clonal expansion before the rearrangement of light-chain loci.Which of the following are beneficial consequences of clonal expansion? (Select all that apply.)

(Multiple Choice)

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Question 17

The latest stages of late pro-B-cell development are recognized by the association of a surrogate light chain with a μ chain.The surrogate light chain is composed of

(Multiple Choice)

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Question 18

Which of the following cell-surface markers differentiates hematopoietic stem cells from other cell constituents in the bone marrow?

(Multiple Choice)

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Question 19

Which of the following is not paired with its correct complement?

(Multiple Choice)

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Question 20

Showing 1 - 20 of 46

A defect in which of the following proteins blocks B-cell development at the pre-B-cell stage,resulting in almost no circulating antibodies in individuals with this defect?

The consequence of allelic exclusion at the immunoglobulin loci ensures that _____.(Select all that apply.)

What is the role of primary lymphoid follicles in eliminating B cells that have antigen receptors specific for soluble self antigen?

Immunological tolerance in the B-cell repertoire is called _ tolerance when it develops in primary lymphoid organs,and _ tolerance when it is induced outside the bone marrow.

When producing monoclonal antibodies,why is it important to use as a fusion partner a myeloma cell that is unable to produce its own immunoglobulin?

Describe the six functionally distinct phases of B-cell development.

A developing B cell unable to generate a productive rearrangement on any of the four light-chain loci will undergo

Which of the following is a characteristic of B-2 cells?

Which of the following would occur after the production of a functional μ chain as a pre-B-cell receptor?

Which of the following is correctly matched? (Select all that apply.)

Negative selection of developing B cells ensures that

An important advantage of having two gene loci (κ and λ)for the light chain is

The circulatory route through a lymphoid tissue for both immature B cells and mature B cells that do not encounter specific antigen is:

All hematopoietic stem cells express

A.Identify properties that are shared by anergic B cells and plasma cells. B.What key property is different?

Large pre-B cells undergo clonal expansion before the rearrangement of light-chain loci.Which of the following are beneficial consequences of clonal expansion? (Select all that apply.)

The latest stages of late pro-B-cell development are recognized by the association of a surrogate light chain with a μ chain.The surrogate light chain is composed of

Which of the following cell-surface markers differentiates hematopoietic stem cells from other cell constituents in the bone marrow?

Which of the following is not paired with its correct complement?

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters

Exam 6: The Development of B Lymphocytes

A defect in which of the following proteins blocks B-cell development at the pre-B-cell stage,resulting in almost no circulating antibodies in individuals with this defect?

The consequence of allelic exclusion at the immunoglobulin loci ensures that _____.(Select all that apply.)

What is the role of primary lymphoid follicles in eliminating B cells that have antigen receptors specific for soluble self antigen?

Immunological tolerance in the B-cell repertoire is called _______ tolerance when it develops in primary lymphoid organs,and _______ tolerance when it is induced outside the bone marrow.

When producing monoclonal antibodies,why is it important to use as a fusion partner a myeloma cell that is unable to produce its own immunoglobulin?

Describe the six functionally distinct phases of B-cell development.

A developing B cell unable to generate a productive rearrangement on any of the four light-chain loci will undergo

Which of the following is a characteristic of B-2 cells?

Which of the following would occur after the production of a functional μ chain as a pre-B-cell receptor?

Which of the following is correctly matched? (Select all that apply.)

Negative selection of developing B cells ensures that

An important advantage of having two gene loci (κ and λ)for the light chain is

The circulatory route through a lymphoid tissue for both immature B cells and mature B cells that do not encounter specific antigen is:

All hematopoietic stem cells express

A.Identify properties that are shared by anergic B cells and plasma cells. B.What key property is different?

Large pre-B cells undergo clonal expansion before the rearrangement of light-chain loci.Which of the following are beneficial consequences of clonal expansion? (Select all that apply.)

The latest stages of late pro-B-cell development are recognized by the association of a surrogate light chain with a μ chain.The surrogate light chain is composed of

Which of the following cell-surface markers differentiates hematopoietic stem cells from other cell constituents in the bone marrow?

Which of the following is not paired with its correct complement?

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters

Immunological tolerance in the B-cell repertoire is called _ tolerance when it develops in primary lymphoid organs,and _ tolerance when it is induced outside the bone marrow.