Question 1

Expression of homeotic genes

Accepted Answer

A) assigns a unique identity to each segment. 
B) defines anterior and posterior ends of the fly. 
C) controls the expression of the segment polarity genes. 
D) subdivides the embryo into a precise number of segments. 
A) assigns a unique identity to each segment. 
B) defines anterior and posterior ends of the fly. 
C) controls the expression of the segment polarity genes. 
D) subdivides the embryo into a precise number of segments.

Question 2

In primary mutant screens,

Accepted Answer

A) mutant flies are identified by morphology and then the mutant genes are isolated and studied. 
B) mutant flies are created by RNAi using random RNA sequences and then the genes affected identified. 
C) mutant flies are created by gain-of-function expression of random genes. 
D) two mutant flies are mated to determine if there is an effect on morphology. 
A) mutant flies are identified by morphology and then the mutant genes are isolated and studied. 
B) mutant flies are created by RNAi using random RNA sequences and then the genes affected identified. 
C) mutant flies are created by gain-of-function expression of random genes. 
D) two mutant flies are mated to determine if there is an effect on morphology.

Question 3

The Aniridia gene in humans is involved in eye formation.Although eye development is very different in flies, this gene is highly conserved.What is the Drosophila homolog of Aniridia?

Accepted Answer

A) eyeless 
B) Pax-6 
C) noeye 
D) ommatidia 
A) eyeless 
B) Pax-6 
C) noeye 
D) ommatidia

Question 4

How would you best follow the timing of expression of a given protein during development in a live animal?

Accepted Answer

A) in situ hybridization 
B) RT-PCR 
C) using a transgenic organism that expresses a GFP fusion protein 
D) microarray analysis 
E) using antibodies against the protein of interest 
A) in situ hybridization 
B) RT-PCR 
C) using a transgenic organism that expresses a GFP fusion protein 
D) microarray analysis 
E) using antibodies against the protein of interest

Question 5

Gene order can be inferred from gene expression patterns because

Accepted Answer

A) an upstream gene can affect downstream gene expression. 
B) mRNAs for proteins in a pathway are produced at the same time, but then are translated only when the proteins are needed. 
C) proteins in a pathway are produced at the same time but the proteins that are not needed are degraded. 
D) mRNAs for proteins in a pathway are produced at the same time and those that are not needed are destabilized by miRNAs. 
E) gene expression does not depend on upstream genes. 
A) an upstream gene can affect downstream gene expression. 
B) mRNAs for proteins in a pathway are produced at the same time, but then are translated only when the proteins are needed. 
C) proteins in a pathway are produced at the same time but the proteins that are not needed are degraded. 
D) mRNAs for proteins in a pathway are produced at the same time and those that are not needed are destabilized by miRNAs. 
E) gene expression does not depend on upstream genes.

Question 6

Which of the following is a zygotic gap gene in Drosophila?

Accepted Answer

A) knirps (kni) 
B) even-skipped (eve) 
C) caudal (cad) 
D) hedgehog (hh) 
A) knirps (kni) 
B) even-skipped (eve) 
C) caudal (cad) 
D) hedgehog (hh)

Question 7

A molecule whose concentration determines the developmental fate of a cell is called

Accepted Answer

A) monomorphic. 
B) a maternal effect gene. 
C) a signaling molecule. 
D) a morphogen. 
A) monomorphic. 
B) a maternal effect gene. 
C) a signaling molecule. 
D) a morphogen.

Expression of homeotic genes

In primary mutant screens,

The Aniridia gene in humans is involved in eye formation.Although eye development is very different in flies, this gene is highly conserved.What is the Drosophila homolog of Aniridia?

How would you best follow the timing of expression of a given protein during development in a live animal?

Gene order can be inferred from gene expression patterns because

Which of the following is a zygotic gap gene in Drosophila?

A molecule whose concentration determines the developmental fate of a cell is called

Genetics: the Study of Biological Information

Mendels Principles of Heredity

Extensions to Mendels Laws

The Chromosome Theory of Inheritance

Linkage, Recombination, and the Mapping of Genes on Chromosomes

DNA Structure, Replication, and Recombination

Anatomy and Function of a Gene: Dissection Through Mutation

Gene Expression: the Flow of Information From Dna to Rna to Protein

Digital Analysis of Dna

Genome Annotation

Analyzing Genomic Variation

The Eukaryotic Chromosome

Chromosomal Rearrangements and Changes in Chromosome Number

Bacterial Genetics

Organellar Inheritance

Gene Regulation in Prokaryotes

Gene Regulation in Eukaryotes

Manipulating the Genomes of Eukaryotes

The Genetics of Cancer

Variation and Selection in Populations

The Genetics of Complex Traits

Filters

Exam 19: The Genetic Analysis of Development

Expression of homeotic genes

In primary mutant screens,

The Aniridia gene in humans is involved in eye formation.Although eye development is very different in flies, this gene is highly conserved.What is the Drosophila homolog of Aniridia?

How would you best follow the timing of expression of a given protein during development in a live animal?

Gene order can be inferred from gene expression patterns because

Which of the following is a zygotic gap gene in Drosophila?

A molecule whose concentration determines the developmental fate of a cell is called

Genetics: the Study of Biological Information

Mendels Principles of Heredity

Extensions to Mendels Laws

The Chromosome Theory of Inheritance

Linkage, Recombination, and the Mapping of Genes on Chromosomes

DNA Structure, Replication, and Recombination

Anatomy and Function of a Gene: Dissection Through Mutation

Gene Expression: the Flow of Information From Dna to Rna to Protein

Digital Analysis of Dna

Genome Annotation

Analyzing Genomic Variation

The Eukaryotic Chromosome

Chromosomal Rearrangements and Changes in Chromosome Number

Bacterial Genetics

Organellar Inheritance

Gene Regulation in Prokaryotes

Gene Regulation in Eukaryotes

Manipulating the Genomes of Eukaryotes

The Genetics of Cancer

Variation and Selection in Populations

The Genetics of Complex Traits

Filters