Question 1

Proteins that consist of two identical polypeptide subunits are classified as

Accepted Answer

A)  monomers. 
B)  oligomers. 
C)  heterodimers. 
D)  homodimers. 
E)  diplomers. 
A)  monomers. 
B)  oligomers. 
C)  heterodimers. 
D)  homodimers. 
E)  diplomers.

Question 2

_______________ motifs function to promote the DNA-binding activity of many transcriptional activator proteins.

Accepted Answer

A)  ABP 
B)  Zinc-finger 
C)  Basolateral 
D)  Leucine zipper 
E)  Medial cleft 
A)  ABP 
B)  Zinc-finger 
C)  Basolateral 
D)  Leucine zipper 
E)  Medial cleft

Question 3

All of the following are associated with the formation of a functional miRNA except

Accepted Answer

A)  lack of an open reading frame (ORF). 
B)  5' GTP cap and 3' poly A tail. 
C)  stem-loop structures. 
D)  translation on ribosomes. 
E)  RNA pol II promoter. 
A)  lack of an open reading frame (ORF). 
B)  5' GTP cap and 3' poly A tail. 
C)  stem-loop structures. 
D)  translation on ribosomes. 
E)  RNA pol II promoter.

Question 4

Which of the following is not true of enhancer DNA sequences?

Accepted Answer

A)  They contain the TATA box regulatory element. 
B)  They may be located upstream of a TATA box. 
C)  They can be more than 10 kilobases from the gene they regulate. 
D)  They may increase or decrease gene transcription levels. 
E)  They may contain multiple regulatory elements. 
A)  They contain the TATA box regulatory element. 
B)  They may be located upstream of a TATA box. 
C)  They can be more than 10 kilobases from the gene they regulate. 
D)  They may increase or decrease gene transcription levels. 
E)  They may contain multiple regulatory elements.

Question 5

RNA interference is a posttranscriptional process for modulating gene expression in prokaryotes.

Accepted Answer

A) True 
 B)False

Question 6

What would be the most likely result of transferring the UTR (untranslated region)from one gene to another?

Accepted Answer

A)  the binding of transcription factors may change 
B)  the posttranslational modification may change 
C)  the ubiquitination of the protein may change 
D)  the half-life of the mRNA may change 
E)  the rate of transcription may be decreased 
A)  the binding of transcription factors may change 
B)  the posttranslational modification may change 
C)  the ubiquitination of the protein may change 
D)  the half-life of the mRNA may change 
E)  the rate of transcription may be decreased

Question 7

The ________________ is the repeating structural unit of chromatin,consisting of approximately 200 base pairs of DNA and associated histone proteins.

Accepted Answer

A)  transcriptosome 
B)  regulosome 
C)  nucleosome 
D)  enhanceosome 
E)  spliceosome 
A)  transcriptosome 
B)  regulosome 
C)  nucleosome 
D)  enhanceosome 
E)  spliceosome

Question 8

_________________ are transcription factors that decrease transcriptional activity by associating with specific enhancer elements or activator proteins.

Accepted Answer

A)  Deregulators 
B)  Depleters 
C)  Regulators 
D)  Repressors 
E)  TBPs 
A)  Deregulators 
B)  Depleters 
C)  Regulators 
D)  Repressors 
E)  TBPs

Question 9

Recessive mutations in the sxl gene in Drosophila are lethal in XX females because

Accepted Answer

A)  sxl functions as a repressor of male-specific dosage-compensation genes. 
B)  recessive mutations indicate an increase in sxl activity. 
C)  these mutations are the result of a loss of both X chromosomes. 
D)  sxl is required for transcription of male-specific genes. 
E)  recessive mutations are always lethal. 
A)  sxl functions as a repressor of male-specific dosage-compensation genes. 
B)  recessive mutations indicate an increase in sxl activity. 
C)  these mutations are the result of a loss of both X chromosomes. 
D)  sxl is required for transcription of male-specific genes. 
E)  recessive mutations are always lethal.

Question 10

In yeast,the SIR protein complex physically interacts with histones H3 and H4 to cause

Accepted Answer

A)  mRNA folding. 
B)  transcriptional silencing. 
C)  transcriptional activation. 
D)  basal transcription. 
E)  initiation of replication. 
A)  mRNA folding. 
B)  transcriptional silencing. 
C)  transcriptional activation. 
D)  basal transcription. 
E)  initiation of replication.

Question 11

One function of chromatin is to increase transcription to a high basal level.

Accepted Answer

A) True 
 B)False

Question 12

Trans-acting proteins that influence transcription are commonly referred to as

Accepted Answer

A)  DNA polymerases. 
B)  tumor suppressors. 
C)  enhancers. 
D)  transcription factors. 
E)  promoter elements. 
A)  DNA polymerases. 
B)  tumor suppressors. 
C)  enhancers. 
D)  transcription factors. 
E)  promoter elements.

Question 13

In repressor quenching,a repressor protein binds directly to an activator protein.

Accepted Answer

A) True 
 B)False

Question 14

Gene A is maternally imprinted while Gene B is paternally imprinted.A mother with Genes A and B imprinted and a father with an imprinted Gene A have a daughter and a son.The children then marry individuals known not to be imprinted for either gene.What is the imprint status of the daughter and son respectively? If each marriage results in the birth of a daughter and a son,what would you expect the imprint status of genes A and B to be for the grandchildren?

Accepted Answer

The mother is imprinted for Genes A and

Question 15

Zinc-finger peptide motifs are responsible for what aspect of protein function?

Accepted Answer

A)  kinase activity 
B)  DNA binding 
C)  mRNA splicing 
D)  DNA replication 
E)  methylation 
A)  kinase activity 
B)  DNA binding 
C)  mRNA splicing 
D)  DNA replication 
E)  methylation

Question 16

_______________ is used to describe a situation in which a gene's expression pattern is dependent upon the parent from whom it was inherited.

Accepted Answer

A)  Genomic imprinting 
B)  Spermatogenesis 
C)  Heterodimerization 
D)  Homodimerization 
E)  Gender-specific RNA stability 
A)  Genomic imprinting 
B)  Spermatogenesis 
C)  Heterodimerization 
D)  Homodimerization 
E)  Gender-specific RNA stability

Question 17

Genomic imprinting is an example of epigenetic alteration of DNA.

Accepted Answer

A) True 
 B)False

Question 18

Why do Max/Max homodimers convert to Myc/Max heterodimers in the presence of Myc protein?

Accepted Answer

A)  Myc has a higher affinity for Max than Max has for Max. 
B)  Myc more tightly associates with DNA,thus recruiting Max monomers to the enhancer. 
C)  The enhancer element being regulated only associates with Myc/Max heterodimers. 
D)  Max is rapidly degraded in the presence of Myc. 
E)  Myc/Myc homodimers are rapidly degraded in the presence of Max. 
A)  Myc has a higher affinity for Max than Max has for Max. 
B)  Myc more tightly associates with DNA,thus recruiting Max monomers to the enhancer. 
C)  The enhancer element being regulated only associates with Myc/Max heterodimers. 
D)  Max is rapidly degraded in the presence of Myc. 
E)  Myc/Myc homodimers are rapidly degraded in the presence of Max.

Question 19

Which of the following is not a mechanism for posttranslational modification controlling gene function?

Accepted Answer

A)  ubiquitination 
B)  methylation 
C)  phosphorylation 
D)  dephosphorylation 
E)  covalent attachment of small molecules to protein. 
A)  ubiquitination 
B)  methylation 
C)  phosphorylation 
D)  dephosphorylation 
E)  covalent attachment of small molecules to protein.

Question 20

Which of the following is true in twin studies of imprinting and epigenetics?

Accepted Answer

A)  Monozygotic twins have identical CpG methylation patterns 
B)  CpG methylation patterns are more similar in dizygotic twins than in monozygotic twins 
C)  Twin studies are not useful in methylation because environment overwhelms heritability in epigenetics 
D)  Dizygotic twins have identical CpG methylation patterns 
E)  CpG methylation patterns are more similar in monozygotic twins than in dizygotic twins 
A)  Monozygotic twins have identical CpG methylation patterns 
B)  CpG methylation patterns are more similar in dizygotic twins than in monozygotic twins 
C)  Twin studies are not useful in methylation because environment overwhelms heritability in epigenetics 
D)  Dizygotic twins have identical CpG methylation patterns 
E)  CpG methylation patterns are more similar in monozygotic twins than in dizygotic twins

Exam 10: Analyzing Genomic Variation

Proteins that consist of two identical polypeptide subunits are classified as

_______________ motifs function to promote the DNA-binding activity of many transcriptional activator proteins.

All of the following are associated with the formation of a functional miRNA except

Which of the following is not true of enhancer DNA sequences?

RNA interference is a posttranscriptional process for modulating gene expression in prokaryotes.

What would be the most likely result of transferring the UTR (untranslated region)from one gene to another?

The ________________ is the repeating structural unit of chromatin,consisting of approximately 200 base pairs of DNA and associated histone proteins.

_________________ are transcription factors that decrease transcriptional activity by associating with specific enhancer elements or activator proteins.

Recessive mutations in the sxl gene in Drosophila are lethal in XX females because

In yeast,the SIR protein complex physically interacts with histones H3 and H4 to cause

One function of chromatin is to increase transcription to a high basal level.

Trans-acting proteins that influence transcription are commonly referred to as

In repressor quenching,a repressor protein binds directly to an activator protein.

Zinc-finger peptide motifs are responsible for what aspect of protein function?

_______________ is used to describe a situation in which a gene's expression pattern is dependent upon the parent from whom it was inherited.

Genomic imprinting is an example of epigenetic alteration of DNA.

Why do Max/Max homodimers convert to Myc/Max heterodimers in the presence of Myc protein?

Which of the following is not a mechanism for posttranslational modification controlling gene function?

Which of the following is true in twin studies of imprinting and epigenetics?

Mendels Principles of Heredity

Extensions to Mendels Laws

The Chromosome Theory of Inheritance

Linkage, Recombination, and the Mapping of Genes on Chromosomes

Dna Structure, Replication, and Recombination

Anatomy and Function of a Gene: Dissection Through Mutation

Gene Expression: the Flow of Information From Dna to Rna to Protein

Digital Analysis of Genomes

Genome Annotation

The Eukaryotic Chromosome

Chromosomal Rearrangements and Changes in Chromosome Number

Bacterial Genetics

Organellar Inheritance

Gene Regulation in Prokaryotes

Gene Regulation in Eukaryotes

Manipulating the Genomes of Eukaryotes

The Genetic Analysis of Development

The Genetics of Cancer

Variation and Selection in Populations

Genetics of Complex Traits

Exploring Synthetic Biology: Concepts, Techniques, and Applications

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