Question 1

Which statement(s) is/are false? (Select all that apply.)

Accepted Answer

A)  ZIP is to PKMζ as the catalytic unit is to PKC. 
B)  PKMζ and PKC are activated by second messengers. 
C)  ZIP prevents late stage LTP but not initial induction. 
D)  ZIP prevents GluA2 AMPA receptors from being trafficked into the PSD. 
E)  None of the above 
A)  ZIP is to PKMζ as the catalytic unit is to PKC. 
B)  PKMζ and PKC are activated by second messengers. 
C)  ZIP prevents late stage LTP but not initial induction. 
D)  ZIP prevents GluA2 AMPA receptors from being trafficked into the PSD. 
E)  None of the above A,B

Question 2

PKMζ lacks an inhibitory unit, so it is always active.

Accepted Answer

A) True 
 B)False  False

Question 3

Which statement(s) about PKMζ is/are true? (Select all that apply.)

Accepted Answer

A)  It can traffic AMPA receptors into the PSD and stay in a perpetually active state. 
B)  It can phosphorylate other proteins. 
C)  It has an inhibitory binding site. 
D)  It can be synthesized in one synapse and captured in another. 
E)  None of the above 
A)  It can traffic AMPA receptors into the PSD and stay in a perpetually active state. 
B)  It can phosphorylate other proteins. 
C)  It has an inhibitory binding site. 
D)  It can be synthesized in one synapse and captured in another. 
E)  None of the above A,B,C,D

Question 4

Name the molecules necessary for the initial translation of PKMζ.

Accepted Answer

The answer of Name the molecules necessary for the initial...

Question 5

If PKMζ is directly apply to a slice, it will _______ synapses.

Accepted Answer

The answer of If PKMζ is directly apply to a...

Question 6

What is ZIP's function?

Accepted Answer

The answer of What is ZIP's function?...

Question 7

Inhibiting PKMζ prevents LTP maintenance because it interferes with_______. (Select all that apply.)

Accepted Answer

A)  NMDA receptor function 
B)  the endocytic removal of AMPA from the PSD 
C)  the release of GluA2 receptors into the synapse 
D)  PSD-95 clustering in the postsynaptic density 
E)  None of the above 
A)  NMDA receptor function 
B)  the endocytic removal of AMPA from the PSD 
C)  the release of GluA2 receptors into the synapse 
D)  PSD-95 clustering in the postsynaptic density 
E)  None of the above

Question 8

How is PKMζ different from PKC?

Accepted Answer

The answer of How is PKMζ different from PKC?...

Question 9

What is the molecular turnover problem?

Accepted Answer

The answer of What is the molecular turnover problem?...

Question 10

The fact that ZIP is nonselective in eliminated LTP suggests that there may be more than one maintenance kinase.

Accepted Answer

A) True 
 B)False

Question 11

At the synaptic level, how does ZIP reverse LTP maintenance?

Accepted Answer

The answer of At the synaptic level, how does ZIP...

Question 12

Kinases such as PKC require a _______ to become active.

Accepted Answer

The answer of Kinases such as PKC require a _______...

Question 13

CaMKII does not have self-perpetuating properties.

Accepted Answer

A) True 
 B)False

Question 14

Does ZIP applied two- or five-hours following induction have any effects on LTP expression?

Accepted Answer

The answer of Does ZIP applied two- or five-hours following...

Question 15

An enlarged spine supports LTP maintenance because _______. (Select all that apply.)

Accepted Answer

A)  it attracts synaptic proteins 
B)  spine size contributes to the selective distribution of synaptic proteins to stimulated spines 
C)  large spines attract microtubules that deliver mRNA to where it is needed 
D)  proteins do not degrade in enlarged spines 
E)  None of the above. 
A)  it attracts synaptic proteins 
B)  spine size contributes to the selective distribution of synaptic proteins to stimulated spines 
C)  large spines attract microtubules that deliver mRNA to where it is needed 
D)  proteins do not degrade in enlarged spines 
E)  None of the above.

Question 16

PKMζ mRNA is prevented from translation by a translator _______ protein.

Accepted Answer

The answer of PKMζ mRNA is prevented from translation by...

Question 17

According to Crick, even though memory molecules decay they can be replaced one at a time so that the existing structure can survive.

Accepted Answer

A) True 
 B)False

Question 18

PKMζ supports LTP maintenance because it _______. (Select all that apply.)

Accepted Answer

A)  contributes to the release of pools of GluA2 receptors 
B)  contributes to the trafficking of PSD-95 into the postsynaptic density 
C)  activates the UPS. 
D)  interferes with the endocytic removal of AMPA receptors from the PSD 
E)  None of the above 
A)  contributes to the release of pools of GluA2 receptors 
B)  contributes to the trafficking of PSD-95 into the postsynaptic density 
C)  activates the UPS. 
D)  interferes with the endocytic removal of AMPA receptors from the PSD 
E)  None of the above

Question 19

A combination of many molecules is required to translate of PKMζ.

Accepted Answer

A) True 
 B)False

Question 20

If the gene for PKMζ is deleted LTP will not be maintained.

Accepted Answer

A) True 
 B)False

Which statement(s) is/are false? (Select all that apply.)

PKMζ lacks an inhibitory unit, so it is always active.

Which statement(s) about PKMζ is/are true? (Select all that apply.)

Name the molecules necessary for the initial translation of PKMζ.

If PKMζ is directly apply to a slice, it will _______ synapses.

What is ZIP's function?

Inhibiting PKMζ prevents LTP maintenance because it interferes with_______. (Select all that apply.)

How is PKMζ different from PKC?

What is the molecular turnover problem?

The fact that ZIP is nonselective in eliminated LTP suggests that there may be more than one maintenance kinase.

At the synaptic level, how does ZIP reverse LTP maintenance?

Kinases such as PKC require a _______ to become active.

CaMKII does not have self-perpetuating properties.

Does ZIP applied two- or five-hours following induction have any effects on LTP expression?

An enlarged spine supports LTP maintenance because _______. (Select all that apply.)

PKMζ mRNA is prevented from translation by a translator _______ protein.

According to Crick, even though memory molecules decay they can be replaced one at a time so that the existing structure can survive.

PKMζ supports LTP maintenance because it _______. (Select all that apply.)

A combination of many molecules is required to translate of PKMζ.

If the gene for PKMζ is deleted LTP will not be maintained.

Introduction: Fundamental Concepts and Historical Foundations

Memory and the Brain: Central Concepts

Generating Long-Term Potentiation

Stabilizing Long-Term Potentiation

Consolidating Ltp: Translation and Transcription

Consolidating Ltp: Specific Mechanisms

Bringing It All Together

Making Memories: Conceptual Issues and Methodologies

Memory Formation: Early Stages

Memory Consolidation

Memory Modulation Systems

The Yin and Yang of Memory: Forgetting Versus Maintenance

Hunting for Engrams

The Fate of Retrieved Memories

Memory Systems and the Hippocampus

The Hippocampus Index and Episodic Memory

When Memories Age

Actions, Habits, and the Cortico-Striatal System

Learning About Danger: the Neurobiology of Fear Memories

Filters

Exam 7: Maintaining Long-Term Potentiation

Which statement(s) is/are false? (Select all that apply.)

PKMζ lacks an inhibitory unit, so it is always active.

Which statement(s) about PKMζ is/are true? (Select all that apply.)

Name the molecules necessary for the initial translation of PKMζ.

If PKMζ is directly apply to a slice, it will _______ synapses.

What is ZIP's function?

Inhibiting PKMζ prevents LTP maintenance because it interferes with_______. (Select all that apply.)

How is PKMζ different from PKC?

What is the molecular turnover problem?

The fact that ZIP is nonselective in eliminated LTP suggests that there may be more than one maintenance kinase.

At the synaptic level, how does ZIP reverse LTP maintenance?

Kinases such as PKC require a _______ to become active.

CaMKII does not have self-perpetuating properties.

Does ZIP applied two- or five-hours following induction have any effects on LTP expression?

An enlarged spine supports LTP maintenance because _______. (Select all that apply.)

PKMζ mRNA is prevented from translation by a translator _______ protein.

According to Crick, even though memory molecules decay they can be replaced one at a time so that the existing structure can survive.

PKMζ supports LTP maintenance because it _______. (Select all that apply.)

A combination of many molecules is required to translate of PKMζ.

If the gene for PKMζ is deleted LTP will not be maintained.

Introduction: Fundamental Concepts and Historical Foundations

Memory and the Brain: Central Concepts

Generating Long-Term Potentiation

Stabilizing Long-Term Potentiation

Consolidating Ltp: Translation and Transcription

Consolidating Ltp: Specific Mechanisms

Bringing It All Together

Making Memories: Conceptual Issues and Methodologies

Memory Formation: Early Stages

Memory Consolidation

Memory Modulation Systems

The Yin and Yang of Memory: Forgetting Versus Maintenance

Hunting for Engrams

The Fate of Retrieved Memories

Memory Systems and the Hippocampus

The Hippocampus Index and Episodic Memory

When Memories Age

Actions, Habits, and the Cortico-Striatal System

Learning About Danger: the Neurobiology of Fear Memories

Filters