Question 1

If C/EBPβ is inhibited, BDNF will be transcribed

Accepted Answer

A) True 
 B)False  False

Question 2

What is the importance of the two distinct peak levels of BDNF expression?

Accepted Answer

One peak of BDNF occurs 1 hour after training and is critical for fear response memory on 1- and 7-day retention intervals. The second occurs 12 hours later and supports the memory on the 7-day retention test.

Question 3

The TOP protein 4E-BP normally interferes with the initiation of local protein synthesis.

Accepted Answer

A) True 
 B)False  True

Question 4

A memory may be considered consolidated when it is no longer vulnerable to transcription and translation inhibitors.

Accepted Answer

A) True 
 B)False

Question 5

Inhibiting protein synthesis just prior to avoidance training _______. (Select all that apply.)

Accepted Answer

A)  impairs memory retention one hour following training 
B)  impairs memory retention at all retention intervals 
C)  impairs retention at all retentions intervals longer than hour 
D)  has no effect on memory retention one hour following training 
E)  None of the above 
A)  impairs memory retention one hour following training 
B)  impairs memory retention at all retention intervals 
C)  impairs retention at all retentions intervals longer than hour 
D)  has no effect on memory retention one hour following training 
E)  None of the above

Question 6

Blocking protein synthesis interferes with the formation of short-term memories.

Accepted Answer

A) True 
 B)False

Question 7

What were the results and implications of systematically injecting the protein-synthesis inhibitor anisomycin prior to fear conditioning?

Accepted Answer

The answer of What were the results and implications of...

Question 8

C/EBPβ is targeted by CREB for transcription.

Accepted Answer

A) True 
 B)False

Question 9

Anisomycin administered just prior to training prevents retention at two-, seven-, and nine-day intervals. But, if anisomycin is administered just a few minutes following training, it only impairs retention at the seven- and nine-day intervals. What does this collection of findings imply?

Accepted Answer

The answer of Anisomycin administered just prior to training prevents...

Question 10

The TOP protein _______ normally interferes with the initiation of local protein synthesis

Accepted Answer

The answer of The TOP protein _______ normally interferes with...

Question 11

Inhibiting protein synthesis should effect short-term memory.

Accepted Answer

A) True 
 B)False

Question 12

How did John Guzowski examine the importance of CREB for memory retention?

Accepted Answer

The answer of How did John Guzowski examine the importance...

Question 13

What is the key independent variable manipulated to determine if a molecule is selectively involved in LTM but not STM?

Accepted Answer

The answer of What is the key independent variable manipulated...

Question 14

What is the evidence that proteins translated in response to the mTORC1 signaling are important for the consolidation of long-term memory but not for producing a short-term memory?

Accepted Answer

The answer of What is the evidence that proteins translated...

Question 15

What is the role of BDNF in the autoregulatory loop?

Accepted Answer

The answer of What is the role of BDNF in...

Question 16

Rapamycin administer prior to training interfered with retention one hour later.

Accepted Answer

A) True 
 B)False

Question 17

When trying to assess the effect of a gene or drug on short-term memory, the retention interval is _______ or less.

Accepted Answer

The answer of When trying to assess the effect of...

Question 18

The initial round of protein synthesis _______. (Select all that apply.)

Accepted Answer

A)  depends on genomic signaling 
B)  depends of post-translation processes 
C)  depends on BDNF $\rightarrow$ TrkB signaling 
D)  depends on both post-translation processes and BDNF signaling 
E)  does not depend on post-translation processes 
A)  depends on genomic signaling 
B)  depends of post-translation processes 
C)  depends on BDNF $\rightarrow$ TrkB signaling 
D)  depends on both post-translation processes and BDNF signaling 
E)  does not depend on post-translation processes

Question 19

The mTORC2 complex regulates protein synthesis but the mTORC1 complex regulates actin polymerization.

Accepted Answer

A) True 
 B)False

Question 20

If rapamycin is delivered _______ avoidance learning it will prevent retentions at retention intervals two days or longer.

Accepted Answer

The answer of If rapamycin is delivered _______ avoidance learning...

If C/EBPβ is inhibited, BDNF will be transcribed

What is the importance of the two distinct peak levels of BDNF expression?

The TOP protein 4E-BP normally interferes with the initiation of local protein synthesis.

A memory may be considered consolidated when it is no longer vulnerable to transcription and translation inhibitors.

Inhibiting protein synthesis just prior to avoidance training _______. (Select all that apply.)

Blocking protein synthesis interferes with the formation of short-term memories.

What were the results and implications of systematically injecting the protein-synthesis inhibitor anisomycin prior to fear conditioning?

C/EBPβ is targeted by CREB for transcription.

Anisomycin administered just prior to training prevents retention at two-, seven-, and nine-day intervals. But, if anisomycin is administered just a few minutes following training, it only impairs retention at the seven- and nine-day intervals. What does this collection of findings imply?

The TOP protein _______ normally interferes with the initiation of local protein synthesis

Inhibiting protein synthesis should effect short-term memory.

How did John Guzowski examine the importance of CREB for memory retention?

What is the key independent variable manipulated to determine if a molecule is selectively involved in LTM but not STM?

What is the evidence that proteins translated in response to the mTORC1 signaling are important for the consolidation of long-term memory but not for producing a short-term memory?

What is the role of BDNF in the autoregulatory loop?

Rapamycin administer prior to training interfered with retention one hour later.

When trying to assess the effect of a gene or drug on short-term memory, the retention interval is _______ or less.

The initial round of protein synthesis _______. (Select all that apply.)

The mTORC2 complex regulates protein synthesis but the mTORC1 complex regulates actin polymerization.

If rapamycin is delivered _______ avoidance learning it will prevent retentions at retention intervals two days or longer.

Introduction: Fundamental Concepts and Historical Foundations

Memory and the Brain: Central Concepts

Generating Long-Term Potentiation

Stabilizing Long-Term Potentiation

Consolidating Ltp: Translation and Transcription

Consolidating Ltp: Specific Mechanisms

Maintaining Long-Term Potentiation

Bringing It All Together

Making Memories: Conceptual Issues and Methodologies

Memory Formation: Early Stages

Memory Modulation Systems

The Yin and Yang of Memory: Forgetting Versus Maintenance

Hunting for Engrams

The Fate of Retrieved Memories

Memory Systems and the Hippocampus

The Hippocampus Index and Episodic Memory

When Memories Age

Actions, Habits, and the Cortico-Striatal System

Learning About Danger: the Neurobiology of Fear Memories

Filters

Exam 11: Memory Consolidation

If C/EBPβ is inhibited, BDNF will be transcribed

What is the importance of the two distinct peak levels of BDNF expression?

The TOP protein 4E-BP normally interferes with the initiation of local protein synthesis.

A memory may be considered consolidated when it is no longer vulnerable to transcription and translation inhibitors.

Inhibiting protein synthesis just prior to avoidance training _______. (Select all that apply.)

Blocking protein synthesis interferes with the formation of short-term memories.

What were the results and implications of systematically injecting the protein-synthesis inhibitor anisomycin prior to fear conditioning?

C/EBPβ is targeted by CREB for transcription.

Anisomycin administered just prior to training prevents retention at two-, seven-, and nine-day intervals. But, if anisomycin is administered just a few minutes following training, it only impairs retention at the seven- and nine-day intervals. What does this collection of findings imply?

The TOP protein _______ normally interferes with the initiation of local protein synthesis

Inhibiting protein synthesis should effect short-term memory.

How did John Guzowski examine the importance of CREB for memory retention?

What is the key independent variable manipulated to determine if a molecule is selectively involved in LTM but not STM?

What is the evidence that proteins translated in response to the mTORC1 signaling are important for the consolidation of long-term memory but not for producing a short-term memory?

What is the role of BDNF in the autoregulatory loop?

Rapamycin administer prior to training interfered with retention one hour later.

When trying to assess the effect of a gene or drug on short-term memory, the retention interval is _______ or less.

The initial round of protein synthesis _______. (Select all that apply.)

The mTORC2 complex regulates protein synthesis but the mTORC1 complex regulates actin polymerization.

If rapamycin is delivered _______ avoidance learning it will prevent retentions at retention intervals two days or longer.

Introduction: Fundamental Concepts and Historical Foundations

Memory and the Brain: Central Concepts

Generating Long-Term Potentiation

Stabilizing Long-Term Potentiation

Consolidating Ltp: Translation and Transcription

Consolidating Ltp: Specific Mechanisms

Maintaining Long-Term Potentiation

Bringing It All Together

Making Memories: Conceptual Issues and Methodologies

Memory Formation: Early Stages

Memory Modulation Systems

The Yin and Yang of Memory: Forgetting Versus Maintenance

Hunting for Engrams

The Fate of Retrieved Memories

Memory Systems and the Hippocampus

The Hippocampus Index and Episodic Memory

When Memories Age

Actions, Habits, and the Cortico-Striatal System

Learning About Danger: the Neurobiology of Fear Memories

Filters