Question 1

What is the function of a synaptic tag and what is its physical basis?

Accepted Answer

Spines compete for the protein needed to sustain them. A tagged spine is more successful in this competition than spines that have not been tagged. It is likely that that the physical basis of the tag is spine with an enlarged actin cytoskeleton that can interact with other proteins such as microtubules to capture protein.

Question 2

The _______ model assumes dendrite is a functional unit that contains all the machinery required to supply synapses with the proteins needed to ensure enduring change (local protein synthesis).

Accepted Answer

clustered plasticity

Question 3

Stimulating spines regulate local dendritic spine dynamics by _______. (Select all that apply.)

Accepted Answer

A)  changing the distribution of ribosomes and mRNA 
B)  initiating genomic signaling 
C)  initiating actin polymerization 
D)  preventing the delivery of mRNA to the spine 
E)  All of the above 
A)  changing the distribution of ribosomes and mRNA 
B)  initiating genomic signaling 
C)  initiating actin polymerization 
D)  preventing the delivery of mRNA to the spine 
E)  All of the above A,C

Question 4

What is an immediate early gene?

Accepted Answer

The answer of What is an immediate early gene?...

Question 5

How does the UPS work?

Accepted Answer

Post-translation modifications

Question 6

How does the UPS contribute to protein synthesis and consolidation?

Accepted Answer

The answer of How does the UPS contribute to protein...

Question 7

The synaptic tag and capture hypothesis is based on three assumptions. What are they?

Accepted Answer

The answer of The synaptic tag and capture hypothesis is...

Question 8

Inhibiting _______ receptors prevents the relocation of mRNA in the dendritic spine region.

Accepted Answer

The answer of Inhibiting _______ receptors prevents the relocation of...

Question 9

mRNA in the dendritic spine region are stationary.

Accepted Answer

A) True 
 B)False

Question 10

What is ubiquitination?

Accepted Answer

It is the process of tagging p

Question 11

Which statement(s) is/are true? (Select all that apply.)

Accepted Answer

A)  Proteasomes degrade ubiquitin tagged proteins. 
B)  Proteasomes tag proteins for degradation. 
C)  Ubiquitin molecules degrade proteins. 
D)  Inhibiting the UPS system prevents enduring LTP. 
E)  None of the above 
A)  Proteasomes degrade ubiquitin tagged proteins. 
B)  Proteasomes tag proteins for degradation. 
C)  Ubiquitin molecules degrade proteins. 
D)  Inhibiting the UPS system prevents enduring LTP. 
E)  None of the above

Question 12

The synaptic tag and capture hypothesis was proposed to explain how plasticity products (mRNA and protein) get targeted to the correct synapses.

Accepted Answer

A) True 
 B)False

Question 13

Drugs such as β-lactone can prevent proteasomes from _______ protein.

Accepted Answer

The answer of Drugs such as β-lactone can prevent proteasomes...

Question 14

The idea that the capture of Arc by inactive CaMKII in unstimulated spines helps preserved potentiated spins is called the _______ hypothesis.

Accepted Answer

The answer of The idea that the capture of Arc...

Question 15

Inhibiting the UPS system inhibits LTP induction and prevents the late enduring phase of LTP.

Accepted Answer

A) True 
 B)False

Question 16

What are the sources of BDNF?

Accepted Answer

The answer of What are the sources of BDNF?...

Question 17

The antisense methodology allows researchers to prevent the translation of specific mRNA into protein

Accepted Answer

A) True 
 B)False

Question 18

Local protein synthesis requires the assembly of TOP proteins into functional ribosomal complexes.

Accepted Answer

A) True 
 B)False

Question 19

According to the Frey and Morris, synaptic tag and capture hypothesis only _______ synapses can capture plasticity products

Accepted Answer

The answer of According to the Frey and Morris, synaptic...

Question 20

The BDNF $\rightarrow$ TrkB $\rightarrow$mTOR signaling pathway initiates local protein synthesis by _______. (Select all that apply.)

Accepted Answer

A)  signaling the nucleus to transcribe genes that support LTP 
B)  removing the inhibitory influence of the TOP protein 4E-BP 
C)  releasing calcium from the endoplasmic reticulum 
D)  allowing new functional ribosomal complexes to form 
E)  None of the above 
A)  signaling the nucleus to transcribe genes that support LTP 
B)  removing the inhibitory influence of the TOP protein 4E-BP 
C)  releasing calcium from the endoplasmic reticulum 
D)  allowing new functional ribosomal complexes to form 
E)  None of the above

What is the function of a synaptic tag and what is its physical basis?

The _______ model assumes dendrite is a functional unit that contains all the machinery required to supply synapses with the proteins needed to ensure enduring change (local protein synthesis).

Stimulating spines regulate local dendritic spine dynamics by _______. (Select all that apply.)

What is an immediate early gene?

How does the UPS work?

How does the UPS contribute to protein synthesis and consolidation?

The synaptic tag and capture hypothesis is based on three assumptions. What are they?

Inhibiting _______ receptors prevents the relocation of mRNA in the dendritic spine region.

mRNA in the dendritic spine region are stationary.

What is ubiquitination?

Which statement(s) is/are true? (Select all that apply.)

The synaptic tag and capture hypothesis was proposed to explain how plasticity products (mRNA and protein) get targeted to the correct synapses.

Drugs such as β-lactone can prevent proteasomes from _______ protein.

The idea that the capture of Arc by inactive CaMKII in unstimulated spines helps preserved potentiated spins is called the _______ hypothesis.

Inhibiting the UPS system inhibits LTP induction and prevents the late enduring phase of LTP.

What are the sources of BDNF?

The antisense methodology allows researchers to prevent the translation of specific mRNA into protein

Local protein synthesis requires the assembly of TOP proteins into functional ribosomal complexes.

According to the Frey and Morris, synaptic tag and capture hypothesis only _______ synapses can capture plasticity products

The BDNF $\rightarrow$ TrkB $\rightarrow$ mTOR signaling pathway initiates local protein synthesis by _______. (Select all that apply.)

Introduction: Fundamental Concepts and Historical Foundations

Memory and the Brain: Central Concepts

Generating Long-Term Potentiation

Stabilizing Long-Term Potentiation

Consolidating Ltp: Translation and Transcription

Maintaining Long-Term Potentiation

Bringing It All Together

Making Memories: Conceptual Issues and Methodologies

Memory Formation: Early Stages

Memory Consolidation

Memory Modulation Systems

The Yin and Yang of Memory: Forgetting Versus Maintenance

Hunting for Engrams

The Fate of Retrieved Memories

Memory Systems and the Hippocampus

The Hippocampus Index and Episodic Memory

When Memories Age

Actions, Habits, and the Cortico-Striatal System

Learning About Danger: the Neurobiology of Fear Memories

Filters

Exam 6: Consolidating Ltp: Specific Mechanisms

What is the function of a synaptic tag and what is its physical basis?

The _______ model assumes dendrite is a functional unit that contains all the machinery required to supply synapses with the proteins needed to ensure enduring change (local protein synthesis).

Stimulating spines regulate local dendritic spine dynamics by _______. (Select all that apply.)

What is an immediate early gene?

How does the UPS work?

How does the UPS contribute to protein synthesis and consolidation?

The synaptic tag and capture hypothesis is based on three assumptions. What are they?

Inhibiting _______ receptors prevents the relocation of mRNA in the dendritic spine region.

mRNA in the dendritic spine region are stationary.

What is ubiquitination?

Which statement(s) is/are true? (Select all that apply.)

The synaptic tag and capture hypothesis was proposed to explain how plasticity products (mRNA and protein) get targeted to the correct synapses.

Drugs such as β-lactone can prevent proteasomes from _______ protein.

The idea that the capture of Arc by inactive CaMKII in unstimulated spines helps preserved potentiated spins is called the _______ hypothesis.

Inhibiting the UPS system inhibits LTP induction and prevents the late enduring phase of LTP.

What are the sources of BDNF?

The antisense methodology allows researchers to prevent the translation of specific mRNA into protein

Local protein synthesis requires the assembly of TOP proteins into functional ribosomal complexes.

According to the Frey and Morris, synaptic tag and capture hypothesis only _______ synapses can capture plasticity products

The BDNF →\rightarrow→ TrkB →\rightarrow→ mTOR signaling pathway initiates local protein synthesis by _______. (Select all that apply.)

Introduction: Fundamental Concepts and Historical Foundations

Memory and the Brain: Central Concepts

Generating Long-Term Potentiation

Stabilizing Long-Term Potentiation

Consolidating Ltp: Translation and Transcription

Maintaining Long-Term Potentiation

Bringing It All Together

Making Memories: Conceptual Issues and Methodologies

Memory Formation: Early Stages

Memory Consolidation

Memory Modulation Systems

The Yin and Yang of Memory: Forgetting Versus Maintenance

Hunting for Engrams

The Fate of Retrieved Memories

Memory Systems and the Hippocampus

The Hippocampus Index and Episodic Memory

When Memories Age

Actions, Habits, and the Cortico-Striatal System

Learning About Danger: the Neurobiology of Fear Memories

Filters

The BDNF $\rightarrow$ TrkB $\rightarrow$ mTOR signaling pathway initiates local protein synthesis by _______. (Select all that apply.)