Exam 7: Maintaining Long-Term Potentiation

PKMζ lacks an inhibitory unit, so it is always inactive.

What was Mary Kennedy's view of "memory maintenance molecules"?

Interfering with a memory maintenance molecule 24 hours after the memory is formed should have no effect on the ability to retrieve the memory.

If ZIP is applied to the slice five hours after LTP is induced it will _______ LTP.

A crucial experiment by Sacktor's group (Tsokas et al., 2016) revealed that antisense to PKMζ erased LTP in both the wildtype and the PKCι/λ mutant mouse.

Describe the two general ways in which PKMζ maintains potentiation.

What two forces operate to return synapses to their basal unpotentiated state?

Explain how PKMζ self-perpetuates.

PKMζ is perpetually active and it self-perpetuates.

ZIP is used to inactivate PKMζ.

Which statement(s) correctly describe(s) PKMζ? (Select all that apply.)

Genomic signaling processes can contribute to memory maintenance because _______. (Select all that apply.)

Where is PKM? translated?

Where is PKMζ mRNA found and translated?

Potentiated synapses endure because there is no pressure to return to their basal unpotentiated state.

Memories outlast the molecules that support the initial synaptic changes.

Even though CaMKII has self-perpetuating properties, this kinase does not appear to be a memory maintenance molecule.

ZIP application prior to induction will prevent late-phase LTP but not initial LTP expression.

_______ is a polypeptide used to inhibit PKMζ function.

PKMζ differs from most kinases because it has no _______ domain.