Exam 10: Memory Formation: Early Stages

GluN1 subunits are not required to form functional NMDA receptors.

An important step in the generation of a memory is the release of glutamate onto dendritic spines.

The CA1KO mouse was able to display LTP in the CA1 regions but not in the dentate gyrus.

A behavioral experience that produces a memory is likely to result in more phosphorylated cofilin and more autophosphorylated CaMKII.

Describe how the radial arm maze can be used to study both working and reference memory.

Ampakines are neither agonists nor antagonists.

The CA1KO mouse was able to display LTP in the dentate gyrus region but not in the CA1.

Fear conditioning increased the presence of phosphorylated CaMKII in dendritic spines. This result means that the conditioning experience _______ this _______.

Which statement(s) is/are true? (Select all that apply.)

GluN1 subunits are necessary to form functional NMDA receptors.

Morris used genetically engineered mice in the first study that investigated the role of NMDA receptors in memory formation.

Explain why it is possible to induce LTP in the dentate gyrus of the CA1KO mouse, but not in the CA1 region of the brain. How does this affect the mouse's performance in the place-learning task?

An enduring LTP can be established independent of any contribution from GluA1 receptors, but it requires GluA2 AMPA receptors.

Every functional NMDA receptor has _______ subunits.

Roberto Malinow's laboratory (Rumpel et al., 2006) used two strategies to prove that fear conditioning drives AMPA receptors into amygdala neuron synapses. What were they?

Richard Morris was the first researcher to directly investigate the role of _______ in memory formation.

Which strategy/strategies did Malinow's laboratory use to investigate the role of AMPA receptors in memory formation? (Select all that apply.)

As the nervous system develops, _______ subunits tend to be replaced by _______ subunits.

Morris was the first to find a possible role for NMDA receptors in memory formation. What was his essentially methodology?

AMPA receptors are needed only for memory acquisition, but NMDA receptors are required for both acquisition and retrieval.