Exam 4: Stabilizing Long-Term Potentiation

In it nonactive state CaMKII bundles active filament.

The delivery of low-frequency stimulation prior to induction of LTP has no effect on its generation but prevents LTP stabilization.

The Rho-ROCK GTPase pathway phosphorylates _______.

What is the role of LIMK in the stabilization of LTP?

Which of the following observations were revealed by single spine imaging studies? (Select all that apply.)

How can a weak stimulus (low frequency) be used to prevent the development of a long-lasting LTP?

Neural cadherins can exist as either monomers or cis-stranded dimers, with equal adhesive properties.

Application of a low-frequency stimulus within a day after the TBS-inducing stimulus is sufficient to interrupt the development of a long-lasting LTP.

Identify a role for inactive CaMKII.

Neutralizing the response of β integrins to extracellular ligands prevents enduring LTP normally produced by TBS, but it has no effect on the initial induction of LTP.

When in a phosphorylated state, cofilin no longer _______ F-actin.

Explain the observation that people with amnesia resulting from an accident often can recall events that took place long ago but not events that occurred within minutes of the accident?

When cofilin is phosphorylated, F-actin is more likely to remain in its filament state.

Why is non-phosphorylated cofilin important to the subsequent enlargement of the spine?

If NMDA receptors are inhibited, caged glutamate will prevent _______.

Large spines endure longer than small spines.

When cofilin is phosphorylated actin polymerization is prevented.

Stabilization of LTP depends on the regulation of actin dynamics.

When cofilin is phosphorylated actin polymerization is prevented.

The severing properties of cofilin are initially important to stabilization. However, it is important this this function be terminated. Why?