Exam 3: Generating Long-Term Potentiation

The molecule _______ traps AMPA receptors in the PSD.

Second messengers can be quickly synthesized.

Which event(s) is/are necessary for the lateral diffusion of AMPA receptors into the PSD? (Select all that apply.)

Ionotropic receptors protrude outside and inside the cell.

NMDA receptors but not AMPA receptors influx calcium.

Glutamate is a(n) _______ neurotransmitter.

Calcium is a second messenger.

Antagonizing NMDA receptor after LTP is established prevents LTP expression.

A major mechanism for the expression of LTP involves increasing the number of _______ receptors in the membrane at synapses.

Constitutive AMPA receptor trafficking is primarily a diffusion process.

Why should inhibiting AMPA receptors prevent the generation of LTP?

Why is the NMDA receptor an ionotropic glutamate receptor?

CaMKII is important in the delivery of AMPA receptors to the PSD because it phosphorylates stargazin.

Stargazin is critical to the opening of the AMPA receptor.

Which statement(s) is/are true? (Select all that apply.)

NMDA receptors are necessary for the _______ of LTP, but not for the _______ of LTP.

PSD-95 is critical to the trapping of AMPA receptors in the PSD.

What were Collingridge's results that established the importance of NMDA receptors to our understanding of LTP?

What is the role of calpain in the generation of LTP?

Which step(s) is/are required to degrade the actin cytoskeleton? (Select all that apply.)