Question 1

Rheumatoid arthritis (RA)is characterized by:

Accepted Answer

A)  joint pain and tenderness. 
B)  the presence of rheumatoid factor in the blood. 
C)  association with HLA-DR genes. 
D)  all of the above. 
A)  joint pain and tenderness. 
B)  the presence of rheumatoid factor in the blood. 
C)  association with HLA-DR genes. 
D)  all of the above. D

Question 2

The laboratory serum agglutination assay for rheumatoid factor (RF):

Accepted Answer

A)  detects IgG rheumatoid factors. 
B)  detects IgM rheumatoid factors. 
C)  does not generate many false-positive results. 
D)  is sensitive to changes in RF titer. 
A)  detects IgG rheumatoid factors. 
B)  detects IgM rheumatoid factors. 
C)  does not generate many false-positive results. 
D)  is sensitive to changes in RF titer. B

Question 3

Immunologic features of rheumatoid arthritis include immune complexes.

Accepted Answer

A) True 
 B)False  True

Question 4

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include persistently high numbers of swollen joints.

Accepted Answer

A) True 
 B)False

Question 5

Immunologic features of rheumatoid arthritis include antinuclear antibodies (ANAs).

Accepted Answer

A) True 
 B)False

Question 6

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include the presence of certain HLA class I alleles.

Accepted Answer

A) True 
 B)False

Question 7

The immunoglobulin classes most often associated with rheumatoid factors (RFs)are:

Accepted Answer

A)  IgM and IgG. 
B)  IgG and IgA. 
C)  IgM and IgA. 
D)  IgA and IgD. 
A)  IgM and IgG. 
B)  IgG and IgA. 
C)  IgM and IgA. 
D)  IgA and IgD.

Question 8

Being rheumatoid factor (RF)-positive correlates with other organ system involvement (e.g. ,vasculitis,Felty's syndrome,Sjögren's syndrome).

Accepted Answer

A) True 
 B)False

Question 9

Rheumatoid arthritis (RA)can be treated with the ______________ class of drugs.

Accepted Answer

A)  nonsteroidal antiinflammatory 
B)  corticosteroid 
C)  disease-modifying antirheumatic 
D)  all of the above 
A)  nonsteroidal antiinflammatory 
B)  corticosteroid 
C)  disease-modifying antirheumatic 
D)  all of the above

Question 10

MATCHING
Match the form of juvenile rheumatoid arthritis (JRA)with the appropriate description.

-Pauciarticular arthritis

Accepted Answer

A) Tends to be HLA-DR5-positive.Polyarthritis begins in five or more joints and occurs in about 40% of patients 
B) Arthritis involving four or fewer joints occurs in 40% of patients.One subgroup is associated with HLA-Dw5 and HLA-DR5 
A) Tends to be HLA-DR5-positive.Polyarthritis begins in five or more joints and occurs in about 40% of patients 
B) Arthritis involving four or fewer joints occurs in 40% of patients.One subgroup is associated with HLA-Dw5 and HLA-DR5

Question 11

The female-to-male ratio in patients with rheumatoid arthritis (RA)is:

Accepted Answer

A)  0.5:1. 
B)  1:1. 
C)  2.5:1. 
D)  2:3. 
A)  0.5:1. 
B)  1:1. 
C)  2.5:1. 
D)  2:3.

Question 12

Pathogenic mechanisms hypothesized for rheumatoid arthritis include:

Accepted Answer

A)  an infective agent or other stimulus binds to receptors on dendritic cells (DCs). 
B)  activated T lymphocytes proliferate and migrate into the joint. 
C)  complement activation. 
D)  both a and b 
A)  an infective agent or other stimulus binds to receptors on dendritic cells (DCs). 
B)  activated T lymphocytes proliferate and migrate into the joint. 
C)  complement activation. 
D)  both a and b

Question 13

The RA agglutination test is based on the reaction between patient antibodies in the serum,known as the rheumatoid factor,and an antigen derived from:

Accepted Answer

A)  human gamma globulin (IgM). 
B)  rabbit gamma globulin (IgM). 
C)  human gamma globulin (IgG). 
D)  rabbit gamma globulin (IgG). 
A)  human gamma globulin (IgM). 
B)  rabbit gamma globulin (IgM). 
C)  human gamma globulin (IgG). 
D)  rabbit gamma globulin (IgG).

Question 14

Being rheumatoid factor (RF)-positive correlates with the severity of the disease (in general).

Accepted Answer

A) True 
 B)False

Question 15

Immunologic features of rheumatoid arthritis include anti-cyclic citrullinated peptide (anti-CCP).

Accepted Answer

A) True 
 B)False

Question 16

A biologic false-positive rheumatoid factor (RF)assay can be manifested by patients with:

Accepted Answer

A)  systemic lupus erythematosus (SL
E) . 
B)  hepatitis. 
C)  syphilis. 
D)  all of the above. 
A)  systemic lupus erythematosus (SL
E) . 
B)  hepatitis. 
C)  syphilis. 
D)  all of the above.

Question 17

Indicate whether the following laboratory assays are highly specific or nonspecific for RA:
1)Cyclic citrullinated peptide (CCP)antibodies
2)Antibodies to anti-perinuclear factor (APF)
3)Antibodies to keratin (AKA)
4)Antinuclear antibodies (ANAs)

Accepted Answer

A)  Highly specific for RA 
B)  Nonspecific for RA 
A)  Highly specific for RA 
B)  Nonspecific for RA

Question 18

MATCHING
Match the form of juvenile rheumatoid arthritis (JRA)with the appropriate description.

-Still's disease

Accepted Answer

A) Tends to be HLA-DR5-positive.Polyarthritis begins in five or more joints and occurs in about 40% of patients 
B) Arthritis involving four or fewer joints occurs in 40% of patients.One subgroup is associated with HLA-Dw5 and HLA-DR5 
A) Tends to be HLA-DR5-positive.Polyarthritis begins in five or more joints and occurs in about 40% of patients 
B) Arthritis involving four or fewer joints occurs in 40% of patients.One subgroup is associated with HLA-Dw5 and HLA-DR5

Question 19

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include low serum levels of acute-phase reactants of immunoglobulin M (IgM)rheumatoid factor.

Accepted Answer

A) True 
 B)False

Question 20

Which of the following immunoglobulins or molecular components is used in rheumatoid factor (RF)rapid slide assays?

Accepted Answer

A)  Fc portion of IgM 
B)  Fc portion of IgG 
C)  IgM 
D)  IgG 
A)  Fc portion of IgM 
B)  Fc portion of IgG 
C)  IgM 
D)  IgG

Exam 30: Rheumatoid Arthritis

Rheumatoid arthritis (RA)is characterized by:

The laboratory serum agglutination assay for rheumatoid factor (RF):

Immunologic features of rheumatoid arthritis include immune complexes.

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include persistently high numbers of swollen joints.

Immunologic features of rheumatoid arthritis include antinuclear antibodies (ANAs).

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include the presence of certain HLA class I alleles.

The immunoglobulin classes most often associated with rheumatoid factors (RFs)are:

Being rheumatoid factor (RF)-positive correlates with other organ system involvement (e.g. ,vasculitis,Felty's syndrome,Sjögren's syndrome).

Rheumatoid arthritis (RA)can be treated with the ______________ class of drugs.

MATCHING Match the form of juvenile rheumatoid arthritis (JRA)with the appropriate description. -Pauciarticular arthritis

The female-to-male ratio in patients with rheumatoid arthritis (RA)is:

Pathogenic mechanisms hypothesized for rheumatoid arthritis include:

The RA agglutination test is based on the reaction between patient antibodies in the serum,known as the rheumatoid factor,and an antigen derived from:

Being rheumatoid factor (RF)-positive correlates with the severity of the disease (in general).

Immunologic features of rheumatoid arthritis include anti-cyclic citrullinated peptide (anti-CCP).

A biologic false-positive rheumatoid factor (RF)assay can be manifested by patients with:

Indicate whether the following laboratory assays are highly specific or nonspecific for RA: 1)Cyclic citrullinated peptide (CCP)antibodies 2)Antibodies to anti-perinuclear factor (APF) 3)Antibodies to keratin (AKA) 4)Antinuclear antibodies (ANAs)

MATCHING Match the form of juvenile rheumatoid arthritis (JRA)with the appropriate description. -Still's disease

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include low serum levels of acute-phase reactants of immunoglobulin M (IgM)rheumatoid factor.

Which of the following immunoglobulins or molecular components is used in rheumatoid factor (RF)rapid slide assays?

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Point-Of-Care Testing

Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Automated Procedures

Molecular Techniques

The Immune Response in Infectious Diseases

A Primer on Vaccines

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Cytomegalovirus

Infectious Mononucleosis

Viral Hepatitis

Rubella and Rubeola Infections

Acquired Immunodeficiency Syndrome

Hypersensitivity Reactions

Immunoproliferative Disorders

Autoimmune Disorders

Systemic Lupus Erythematosus

Solid Organ Transplantation

Bone Marrow Transplantation

Tumor Immunology

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