Question 1

Acute lymphoblastic leukemia is treatable by stem cell transplantation.

Accepted Answer

A) True 
 B)False  True

Question 2

A major complication in patients with a bone marrow (BM)or peripheral blood stem cell (PBSC)transplant during the first month after transplantation is:

Accepted Answer

A)  fungal infection. 
B)  cytomegalovirus (CMV)infection. 
C)  hepatitis B infection. 
D)  graft-versus-host disease (GVH
D) . 
A)  fungal infection. 
B)  cytomegalovirus (CMV)infection. 
C)  hepatitis B infection. 
D)  graft-versus-host disease (GVH
D) . D

Question 3

Match the chemotherapeutic agents with an example or description.

-Alkylating agents

Accepted Answer

A) 5-Fluorouracil (5-FU) 
B) First agents used in bone marrow transplantation 
C) Cytotoxic predominantly during M phase or G2 and M phases of cell cycle 
A) 5-Fluorouracil (5-FU) 
B) First agents used in bone marrow transplantation 
C) Cytotoxic predominantly during M phase or G2 and M phases of cell cycle B

Question 4

The risk of developing graft-versus-host disease (GVHD)is strongly linked to the:

Accepted Answer

A)  use of cells from an unrelated donor. 
B)  use of autologous bone marrow (BM)or peripheral blood stem cells (PBSCs). 
C)  degree of HLA mismatch between patient and donor. 
D)  depletion of T lymphocytes from the transplant. 
A)  use of cells from an unrelated donor. 
B)  use of autologous bone marrow (BM)or peripheral blood stem cells (PBSCs). 
C)  degree of HLA mismatch between patient and donor. 
D)  depletion of T lymphocytes from the transplant.

Question 5

Match the chemotherapeutic agents with an example or description.

-Antimetabolites

Accepted Answer

A) 5-Fluorouracil (5-FU) 
B) First agents used in bone marrow transplantation 
C) Cytotoxic predominantly during M phase or G2 and M phases of cell cycle 
A) 5-Fluorouracil (5-FU) 
B) First agents used in bone marrow transplantation 
C) Cytotoxic predominantly during M phase or G2 and M phases of cell cycle

Question 6

Aplastic anemia is treatable by stem cell transplantation.

Accepted Answer

A) True 
 B)False

Question 7

PBSCs are obtained by:

Accepted Answer

A)  phlebotomy. 
B)  apheresis. 
C)  leukapheresis. 
D)  both b and c 
A)  phlebotomy. 
B)  apheresis. 
C)  leukapheresis. 
D)  both b and c

Question 8

The goal of a CD34+ antigen harvest is to infuse a minimum dose of _______ CD34+ cells of per kilogram of recipient weight.

Accepted Answer

A)    
B)    
C)    
D)    
A)    
B)    
C)    
D)

Question 9

MATCHING
Match the transplant types with the appropriate description.

-Syngeneic

Accepted Answer

A) Stem cells from identical twins 
B) Marrow from a related or unrelated donor 
C) Transplant of own cells 
A) Stem cells from identical twins 
B) Marrow from a related or unrelated donor 
C) Transplant of own cells

Question 10

Complications of bone marrow or peripheral blood stem cell (PBSC)transplantation include:

Accepted Answer

A)  infection and graft-versus-host disease (GVH
D) . 
B)  acute rejection and organ damage. 
C)  chronic rejection and death. 
D)  all of the above. 
A)  infection and graft-versus-host disease (GVH
D) . 
B)  acute rejection and organ damage. 
C)  chronic rejection and death. 
D)  all of the above.

Question 11

The cryopreservatives DMSO and pentastarch are used to:

Accepted Answer

A)  prevent toxicity. 
B)  keep cells from dehydrating. 
C)  prevent bacterial growth. 
D)  prevent fungal growth. 
A)  prevent toxicity. 
B)  keep cells from dehydrating. 
C)  prevent bacterial growth. 
D)  prevent fungal growth.

Question 12

Toxicities and side effects associated with the infusion of cryopreserved products are mainly caused by:

Accepted Answer

A)  DMSO preservative. 
B)  volume overload. 
C)  glycerol preservative. 
D)  both a and b 
A)  DMSO preservative. 
B)  volume overload. 
C)  glycerol preservative. 
D)  both a and b

Question 13

Pretransplant evaluation of a bone marrow recipient includes:

Accepted Answer

A)  HLA tissue typing. 
B)  disease status. 
C)  compatibility of donor and recipient. 
D)  all of the above. 
A)  HLA tissue typing. 
B)  disease status. 
C)  compatibility of donor and recipient. 
D)  all of the above.

Question 14

Differences between donor and recipient ABO and Rh blood groups have ______ effect on marrow engraftment.

Accepted Answer

A)  no 
B)  some 
C)  a major 
D)  an overwhelming 
A)  no 
B)  some 
C)  a major 
D)  an overwhelming

Question 15

Match the chemotherapeutic agents with an example or description.

-Alkaloids

Accepted Answer

A) 5-Fluorouracil (5-FU) 
B) First agents used in bone marrow transplantation 
C) Cytotoxic predominantly during M phase or G2 and M phases of cell cycle 
A) 5-Fluorouracil (5-FU) 
B) First agents used in bone marrow transplantation 
C) Cytotoxic predominantly during M phase or G2 and M phases of cell cycle

Question 16

MATCHING
Match the transplant types with the appropriate description.

-Autologous

Accepted Answer

A) Stem cells from identical twins 
B) Marrow from a related or unrelated donor 
C) Transplant of own cells 
A) Stem cells from identical twins 
B) Marrow from a related or unrelated donor 
C) Transplant of own cells

Question 17

Which of the following statements about progenitor blood cells is correct?

Accepted Answer

A)  They are pluripotent. 
B)  They are found in bone marrow and peripheral circulating blood. 
C)  They contain precursor cells to leukocytes and platelets. 
D)  All of the above. 
A)  They are pluripotent. 
B)  They are found in bone marrow and peripheral circulating blood. 
C)  They contain precursor cells to leukocytes and platelets. 
D)  All of the above.

Question 18

The most common type(s)of microorganisms found in bone marrow (BM)or peripheral blood stem cells (PBSCs)after transplantation infections is (are):

Accepted Answer

A)  fungi. 
B)  viruses. 
C)  bacteria. 
D)  both a and c 
A)  fungi. 
B)  viruses. 
C)  bacteria. 
D)  both a and c

Question 19

Increased cell selection and purging of grafts using cell surface membrane markers has resulted in:

Accepted Answer

A)  decreased risk of tumor reinfusion into autologous recipients. 
B)  decreases in the amount of T cells infused in allogeneic recipients. 
C)  a lower incidence of GVHD. 
D)  both a and b 
A)  decreased risk of tumor reinfusion into autologous recipients. 
B)  decreases in the amount of T cells infused in allogeneic recipients. 
C)  a lower incidence of GVHD. 
D)  both a and b

Question 20

If bone marrow or peripheral blood stem cells (PBSCs)are not used within _______ hours,the specimen must be frozen.

Accepted Answer

A)  8 
B)  12 
C)  24 
D)  96 
A)  8 
B)  12 
C)  24 
D)  96

Exam 32: Bone Marrow Transplantation

Acute lymphoblastic leukemia is treatable by stem cell transplantation.

A major complication in patients with a bone marrow (BM)or peripheral blood stem cell (PBSC)transplant during the first month after transplantation is:

Match the chemotherapeutic agents with an example or description. -Alkylating agents

The risk of developing graft-versus-host disease (GVHD)is strongly linked to the:

Match the chemotherapeutic agents with an example or description. -Antimetabolites

Aplastic anemia is treatable by stem cell transplantation.

PBSCs are obtained by:

The goal of a CD34+ antigen harvest is to infuse a minimum dose of _______ CD34+ cells of per kilogram of recipient weight.

MATCHING Match the transplant types with the appropriate description. -Syngeneic

Complications of bone marrow or peripheral blood stem cell (PBSC)transplantation include:

The cryopreservatives DMSO and pentastarch are used to:

Toxicities and side effects associated with the infusion of cryopreserved products are mainly caused by:

Pretransplant evaluation of a bone marrow recipient includes:

Differences between donor and recipient ABO and Rh blood groups have ______ effect on marrow engraftment.

Match the chemotherapeutic agents with an example or description. -Alkaloids

MATCHING Match the transplant types with the appropriate description. -Autologous

Which of the following statements about progenitor blood cells is correct?

The most common type(s)of microorganisms found in bone marrow (BM)or peripheral blood stem cells (PBSCs)after transplantation infections is (are):

Increased cell selection and purging of grafts using cell surface membrane markers has resulted in:

If bone marrow or peripheral blood stem cells (PBSCs)are not used within _______ hours,the specimen must be frozen.

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Point-Of-Care Testing

Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Automated Procedures

Molecular Techniques

The Immune Response in Infectious Diseases

A Primer on Vaccines

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Cytomegalovirus

Infectious Mononucleosis

Viral Hepatitis

Rubella and Rubeola Infections

Acquired Immunodeficiency Syndrome

Hypersensitivity Reactions

Immunoproliferative Disorders

Autoimmune Disorders

Systemic Lupus Erythematosus

Rheumatoid Arthritis

Solid Organ Transplantation

Tumor Immunology

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