Question 1

Similarities between organ-specific and organ-nonspecific disorders include the fact that antibodies may not appear in each of the main immunoglobulin classes.

Accepted Answer

A) True 
 B)False  False

Question 2

The cause of insulin-dependent diabetes mellitus is:

Accepted Answer

A)  immune destruction of B lymphocytes in pancreatic islets. 
B)  immune destruction of T lymphocytes in pancreatic islets. 
C)  anti-parietal cell antibody. 
D)  anti-islet cell antigen. 
A)  immune destruction of B lymphocytes in pancreatic islets. 
B)  immune destruction of T lymphocytes in pancreatic islets. 
C)  anti-parietal cell antibody. 
D)  anti-islet cell antigen. A

Question 3

Pernicious anemia (PA)is characterized by:

Accepted Answer

A)  deficiency of vitamin B12. 
B)  presence of antiparietal antibodies. 
C)  presence of intrinsic factor (IF)-blocking antibodies. 
D)  all of the above. 
A)  deficiency of vitamin B12. 
B)  presence of antiparietal antibodies. 
C)  presence of intrinsic factor (IF)-blocking antibodies. 
D)  all of the above. D

Question 4

Similarities between organ-specific and organ-nonspecific disorders include autoantibody tests of diagnostic value.

Accepted Answer

A) True 
 B)False

Question 5

Self-recognition (tolerance)is induced by:

Accepted Answer

A)  elimination of the small clone of immunocompetent cells programmed to react with the antigen. 
B)  induction of unresponsiveness in immunocompetent cells. 
C)  induction of unresponsiveness through triggering of a suppressor mechanism. 
D)  all of the above. 
A)  elimination of the small clone of immunocompetent cells programmed to react with the antigen. 
B)  induction of unresponsiveness in immunocompetent cells. 
C)  induction of unresponsiveness through triggering of a suppressor mechanism. 
D)  all of the above.

Question 6

MATCHING
Match the statements with the correct type of disorder (a or b).

-Parenchymal destruction by questionable cell-mediated hypersensitivity or antibodies.

Accepted Answer

A) Organ-specific 
B) Organ- nonspecific 
A) Organ-specific 
B) Organ- nonspecific

Question 7

Most immunologically mediated renal diseases fall into one of the following categories,except:

Accepted Answer

A)  association with circulating immune complexes. 
B)  association with circulating antigen. 
C)  association with anti-glomerular basement membrane antibody. 
D)  membranoproliferative glomerulonephritis. 
A)  association with circulating immune complexes. 
B)  association with circulating antigen. 
C)  association with anti-glomerular basement membrane antibody. 
D)  membranoproliferative glomerulonephritis.

Question 8

MATCHING
Match the statements with the correct type of disorder (a or b).

-Antigens only available to lymphoid system in low concentrations.

Accepted Answer

A) Organ-specific 
B) Organ- nonspecific 
A) Organ-specific 
B) Organ- nonspecific

Question 9

MATCHING
Match the statements with the correct type of disorder (a or b).

-Antigens accessible at higher concentrations.

Accepted Answer

A) Organ-specific 
B) Organ- nonspecific 
A) Organ-specific 
B) Organ- nonspecific

Question 10

MATCHING
Match the statements with the correct type of disorder (a or b).

-Lesions caused by deposition of antigen-antibody (immune)complexes.

Accepted Answer

A) Organ-specific 
B) Organ- nonspecific 
A) Organ-specific 
B) Organ- nonspecific

Question 11

Match the term with the appropriate definition.
-ANA

Accepted Answer

A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia 
A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia

Question 12

Match the term with the appropriate definition.
-Antineutrophil antibody

Accepted Answer

A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia 
A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia

Question 13

Anticardiolipin antibody is associated with:

Accepted Answer

A)  rheumatoid arthritis (R
A) . 
B)  multiple sclerosis (MS). 
C)  pernicious anemia (P
A) . 
D)  systemic lupus erythematosus (SL
E) . 
A)  rheumatoid arthritis (R
A) . 
B)  multiple sclerosis (MS). 
C)  pernicious anemia (P
A) . 
D)  systemic lupus erythematosus (SL
E) .

Question 14

Which of the following disorders is considered to be organ-nonspecific?

Accepted Answer

A)  Systemic lupus erythematosus 
B)  Insulin-dependent diabetes (type 1) 
C)  Hashimoto's thyroiditis 
D)  Carditis 
A)  Systemic lupus erythematosus 
B)  Insulin-dependent diabetes (type 1) 
C)  Hashimoto's thyroiditis 
D)  Carditis

Question 15

An early marker of beta pancreatic cell destruction is _________________ antibody.

Accepted Answer

A)  anti-DNA 
B)  anti-islet cell 
C)  antinuclear 
D)  anti-intrinsic factor 
A)  anti-DNA 
B)  anti-islet cell 
C)  antinuclear 
D)  anti-intrinsic factor

Question 16

The definition of autoimmunity is a(n):

Accepted Answer

A)  increase in tolerance to self antigens. 
B)  increase in immunosuppressive activities. 
C)  increased sensitivity to foreign antigens. 
D)  decreased tolerance to self antigens. 
A)  increase in tolerance to self antigens. 
B)  increase in immunosuppressive activities. 
C)  increased sensitivity to foreign antigens. 
D)  decreased tolerance to self antigens.

Question 17

Match the term with the appropriate definition.
-Anti-Scl antibody

Accepted Answer

A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia 
A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia

Question 18

Similarities between organ-specific and organ-nonspecific disorders include the fact that circulating autoantibodies react with normal body constituents.

Accepted Answer

A) True 
 B)False

Question 19

The basic immunologic mechanism responsible for autoimmune disorders is related to:

Accepted Answer

A)  activated T lymphocytes. 
B)  failure to activate B lymphocytes. 
C)  defective phagocytosis. 
D)  deposition of circulating immune complexes. 
A)  activated T lymphocytes. 
B)  failure to activate B lymphocytes. 
C)  defective phagocytosis. 
D)  deposition of circulating immune complexes.

Question 20

The immunologic manifestations of multiple sclerosis (MS)include all the following except:

Accepted Answer

A)  antimyelin antibodies. 
B)  an oligoclonal increase in CSF immunoglobulin. 
C)  T cell-dependent inflammatory demyelination 
D)  myelin antibodies are detectable in the CSF 
A)  antimyelin antibodies. 
B)  an oligoclonal increase in CSF immunoglobulin. 
C)  T cell-dependent inflammatory demyelination 
D)  myelin antibodies are detectable in the CSF

Exam 28: Autoimmune Disorders

Similarities between organ-specific and organ-nonspecific disorders include the fact that antibodies may not appear in each of the main immunoglobulin classes.

The cause of insulin-dependent diabetes mellitus is:

Pernicious anemia (PA)is characterized by:

Similarities between organ-specific and organ-nonspecific disorders include autoantibody tests of diagnostic value.

Self-recognition (tolerance)is induced by:

MATCHING Match the statements with the correct type of disorder (a or b). -Parenchymal destruction by questionable cell-mediated hypersensitivity or antibodies.

Most immunologically mediated renal diseases fall into one of the following categories,except:

MATCHING Match the statements with the correct type of disorder (a or b). -Antigens only available to lymphoid system in low concentrations.

MATCHING Match the statements with the correct type of disorder (a or b). -Antigens accessible at higher concentrations.

MATCHING Match the statements with the correct type of disorder (a or b). -Lesions caused by deposition of antigen-antibody (immune)complexes.

Match the term with the appropriate definition. -ANA

Match the term with the appropriate definition. -Antineutrophil antibody

Anticardiolipin antibody is associated with:

Which of the following disorders is considered to be organ-nonspecific?

An early marker of beta pancreatic cell destruction is _________________ antibody.

The definition of autoimmunity is a(n):

Match the term with the appropriate definition. -Anti-Scl antibody

Similarities between organ-specific and organ-nonspecific disorders include the fact that circulating autoantibodies react with normal body constituents.

The basic immunologic mechanism responsible for autoimmune disorders is related to:

The immunologic manifestations of multiple sclerosis (MS)include all the following except:

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Point-Of-Care Testing

Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Automated Procedures

Molecular Techniques

The Immune Response in Infectious Diseases

A Primer on Vaccines

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Cytomegalovirus

Infectious Mononucleosis

Viral Hepatitis

Rubella and Rubeola Infections

Acquired Immunodeficiency Syndrome

Hypersensitivity Reactions

Immunoproliferative Disorders

Systemic Lupus Erythematosus

Rheumatoid Arthritis

Solid Organ Transplantation

Bone Marrow Transplantation

Tumor Immunology

Filters