Question 1

A diffused or homogeneous pattern in antinuclear antibody (ANA)testing characterizes:

Accepted Answer

A)  nDNA,ds-DNA,histones,ssDNA,DNP,or histones. 
B)  Sm,RNP,SS-A,SS-B,hnRNP,and others. 
C)  centromere proteins A,B,and C. 
D)  nuclear lamins A,B,and C and nuclear pore proteins. 
A)  nDNA,ds-DNA,histones,ssDNA,DNP,or histones. 
B)  Sm,RNP,SS-A,SS-B,hnRNP,and others. 
C)  centromere proteins A,B,and C. 
D)  nuclear lamins A,B,and C and nuclear pore proteins. A

Question 2

The overall incidence of SLE has an increased frequency among:

Accepted Answer

A)  African Americans. 
B)  Native Americans. 
C)  Puerto Ricans. 
D)  all of the above. 
A)  African Americans. 
B)  Native Americans. 
C)  Puerto Ricans. 
D)  all of the above. D

Question 3

A speckled pattern in antinuclear antibody (ANA)testing characterizes:

Accepted Answer

A)  dsDNA,histones,and DNA-histone complexes. 
B)  anti-RNP and anti-Sm. 
C)  centromere proteins A,B,and C. 
D)  nuclear lamins A,B,and C and nuclear pore proteins. 
A)  dsDNA,histones,and DNA-histone complexes. 
B)  anti-RNP and anti-Sm. 
C)  centromere proteins A,B,and C. 
D)  nuclear lamins A,B,and C and nuclear pore proteins. B

Question 4

A condition called the _________________ syndrome can be secondary to lupus and may complicate pregnancy.

Accepted Answer

A)  antiphospholipid 
B)  antinuclear antibody 
C)  immune complex 
D)  plasma cell 
A)  antiphospholipid 
B)  antinuclear antibody 
C)  immune complex 
D)  plasma cell

Question 5

The site of deposition of immune complexes in systemic lupus erythematosus (SLE)is determined by:

Accepted Answer

A)  molecular configuration. 
B)  immunoglobulin class. 
C)  complement-fixing ability. 
D)  all of the above. 
A)  molecular configuration. 
B)  immunoglobulin class. 
C)  complement-fixing ability. 
D)  all of the above.

Question 6

One of the most potent inducers of abnormalities and clinical manifestations of SLE is:

Accepted Answer

A)  hydralazine. 
B)  procainamide. 
C)  isoniazid. 
D)  both a and b 
A)  hydralazine. 
B)  procainamide. 
C)  isoniazid. 
D)  both a and b

Question 7

MATCHING
Match the interpretation of the ANA staining pattern to its respective antibody.

-Peripheral or rim

Accepted Answer

A) 4-6S RNP 
B) Antibody to nucleolar RNA 
C) Antibody to any extractable nuclear antigen devoid of DNA or histone 
D) nDNA 
A) 4-6S RNP 
B) Antibody to nucleolar RNA 
C) Antibody to any extractable nuclear antigen devoid of DNA or histone 
D) nDNA

Question 8

Which autoimmune disorder is indicated by an increased titer of anti-Sm (anti-Smith)antibody?

Accepted Answer

A)  Rheumatoid arthritis 
B)  Systemic lupus erythematosus 
C)  Progressive systemic sclerosis 
D)  Polymyositis 
A)  Rheumatoid arthritis 
B)  Systemic lupus erythematosus 
C)  Progressive systemic sclerosis 
D)  Polymyositis

Question 9

Serologic assessment of renal disease in systemic lupus erythematosus (SLE)includes:

Accepted Answer

A)  cryoglobulin level assay. 
B)  serum electrophoresis. 
C)  serum creatinine level assay. 
D)  urinary protein excretion. 
A)  cryoglobulin level assay. 
B)  serum electrophoresis. 
C)  serum creatinine level assay. 
D)  urinary protein excretion.

Question 10

Patients with SLE characteristically manifest:

Accepted Answer

A)  a photosensitive facial rash. 
B)  polyarthritis. 
C)  dermatitis. 
D)  all of the above. 
A)  a photosensitive facial rash. 
B)  polyarthritis. 
C)  dermatitis. 
D)  all of the above.

Question 11

The most frequent cause(s)of mortality in hospitalized patients with SLE and progressive renal involvement or CNS disease is (are):

Accepted Answer

A)  infection 
B)  anemia 
C)  secondary malignancy 
D)  both a and b 
A)  infection 
B)  anemia 
C)  secondary malignancy 
D)  both a and b

Question 12

Many of the clinical manifestations of systemic lupus erythematosus are a consequence of:

Accepted Answer

A)  tissue damage mediated by immune complexes. 
B)  thrombocytopenia. 
C)  antiphospholipid syndrome. 
D)  antibodies to cell surface molecules. 
A)  tissue damage mediated by immune complexes. 
B)  thrombocytopenia. 
C)  antiphospholipid syndrome. 
D)  antibodies to cell surface molecules.

Question 13

A major cellular immunologic feature of SLE is:

Accepted Answer

A)  lack of generalized suppressor T cell function. 
B)  reduction of generalized suppressor T cell function. 
C)  hyperproduction of helper T cells. 
D)  all of the above. 
A)  lack of generalized suppressor T cell function. 
B)  reduction of generalized suppressor T cell function. 
C)  hyperproduction of helper T cells. 
D)  all of the above.

Question 14

Antibodies directed against ___________ cells,including the membrane molecules that mediate their responses,are regularly detected in patients with SLE.

Accepted Answer

A)  T 
B)  B 
C)  plasma 
D)  macrophage 
A)  T 
B)  B 
C)  plasma 
D)  macrophage

Question 15

The most common form of lupus is:

Accepted Answer

A)  discoid. 
B)  systemic. 
C)  drug-induced. 
A)  discoid. 
B)  systemic. 
C)  drug-induced.

Question 16

SLE is more common in:

Accepted Answer

A)  female infants. 
B)  male infants. 
C)  adult women. 
D)  adult men. 
A)  female infants. 
B)  male infants. 
C)  adult women. 
D)  adult men.

Question 17

MATCHING
Match the interpretation of the ANA staining pattern to its respective antibody.

-Nucleolar

Accepted Answer

A) 4-6S RNP 
B) Antibody to nucleolar RNA 
C) Antibody to any extractable nuclear antigen devoid of DNA or histone 
D) nDNA 
A) 4-6S RNP 
B) Antibody to nucleolar RNA 
C) Antibody to any extractable nuclear antigen devoid of DNA or histone 
D) nDNA

Question 18

Patients with systemic lupus erythematosus exhibit serum antibodies that include:

Accepted Answer

A)  nuclear components. 
B)  cell surface and cytoplasmic antigens. 
C)  immunoglobulin G (IgG). 
D)  all of the above. 
A)  nuclear components. 
B)  cell surface and cytoplasmic antigens. 
C)  immunoglobulin G (IgG). 
D)  all of the above.

Question 19

Laboratory features of SLE include:

Accepted Answer

A)  the presence of ANAs. 
B)  circulating anticoagulant and immune complexes. 
C)  decreased levels of complement. 
D)  all of the above. 
A)  the presence of ANAs. 
B)  circulating anticoagulant and immune complexes. 
C)  decreased levels of complement. 
D)  all of the above.

Question 20

Fill in the blanks in the table.
Antibodies in Systemic Rheumatic Diseases
   
A)Anti-native DNA
B)Anti-Jo-1
C)Anti-Scl-1

Accepted Answer

1,A;2,C;3,B
Antibodi

Exam 29: Systemic Lupus Erythematosus

A diffused or homogeneous pattern in antinuclear antibody (ANA)testing characterizes:

The overall incidence of SLE has an increased frequency among:

A speckled pattern in antinuclear antibody (ANA)testing characterizes:

A condition called the _________________ syndrome can be secondary to lupus and may complicate pregnancy.

The site of deposition of immune complexes in systemic lupus erythematosus (SLE)is determined by:

One of the most potent inducers of abnormalities and clinical manifestations of SLE is:

MATCHING Match the interpretation of the ANA staining pattern to its respective antibody. -Peripheral or rim

Which autoimmune disorder is indicated by an increased titer of anti-Sm (anti-Smith)antibody?

Serologic assessment of renal disease in systemic lupus erythematosus (SLE)includes:

Patients with SLE characteristically manifest:

The most frequent cause(s)of mortality in hospitalized patients with SLE and progressive renal involvement or CNS disease is (are):

Many of the clinical manifestations of systemic lupus erythematosus are a consequence of:

A major cellular immunologic feature of SLE is:

Antibodies directed against ___________ cells,including the membrane molecules that mediate their responses,are regularly detected in patients with SLE.

The most common form of lupus is:

SLE is more common in:

MATCHING Match the interpretation of the ANA staining pattern to its respective antibody. -Nucleolar

Patients with systemic lupus erythematosus exhibit serum antibodies that include:

Laboratory features of SLE include:

Fill in the blanks in the table. Antibodies in Systemic Rheumatic Diseases A)Anti-native DNA B)Anti-Jo-1 C)Anti-Scl-1

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Point-Of-Care Testing

Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Automated Procedures

Molecular Techniques

The Immune Response in Infectious Diseases

A Primer on Vaccines

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Cytomegalovirus

Infectious Mononucleosis

Viral Hepatitis

Rubella and Rubeola Infections

Acquired Immunodeficiency Syndrome

Hypersensitivity Reactions

Immunoproliferative Disorders

Autoimmune Disorders

Rheumatoid Arthritis

Solid Organ Transplantation

Bone Marrow Transplantation

Tumor Immunology

Filters