Question 1

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD).

-Recipients of autologous or allogeneic bone marrow grafts

Accepted Answer

A) High-risk patients 
B) Intermediate-risk patients 
C) Low-risk patients 
A) High-risk patients 
B) Intermediate-risk patients 
C) Low-risk patients A

Question 2

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD).

-Patients with aplastic anemia receiving antithymocyte globulin

Accepted Answer

A) High-risk patients 
B) Intermediate-risk patients 
C) Low-risk patients 
A) High-risk patients 
B) Intermediate-risk patients 
C) Low-risk patients B

Question 3

MATCHING
Match the terms with the appropriate definition.

-Syngraft

Accepted Answer

A) Graft between individuals of different species (e.g. ,pig heart valve to a human heart) 
B) Graft transferred from one position to another in the same individual (e.g. ,skin,hair,bone) 
C) Graft between genetically different recipient and donor of the same species;grafted donor tissue or organ contains antigens not present in recipient 
D) Graft transplanted between different but identical recipient and donor (e.g. ,kidney transplant between monozygous twins) 
A) Graft between individuals of different species (e.g. ,pig heart valve to a human heart) 
B) Graft transferred from one position to another in the same individual (e.g. ,skin,hair,bone) 
C) Graft between genetically different recipient and donor of the same species;grafted donor tissue or organ contains antigens not present in recipient 
D) Graft transplanted between different but identical recipient and donor (e.g. ,kidney transplant between monozygous twins) D

Question 4

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD).

-Children with severe congenital immunodeficiency syndromes involving T lymphocytes

Accepted Answer

A) High-risk patients 
B) Intermediate-risk patients 
C) Low-risk patients 
A) High-risk patients 
B) Intermediate-risk patients 
C) Low-risk patients

Question 5

Immunosuppression is used for the suppression of established rejection.

Accepted Answer

A) True 
 B)False

Question 6

Which of the following classes of MHC antigens is necessary for antigen recognition by CD4+ T lymphocytes?

Accepted Answer

A)  class I 
B)  class II 
C)  both class I and class II 
D)  neither class I nor class II 
A)  class I 
B)  class II 
C)  both class I and class II 
D)  neither class I nor class II

Question 7

In posttransfusion graft-versus-host reaction,symptoms begin within ________ day(s)after transfusion.

Accepted Answer

A)  1 
B)  2 to 4 
C)  3 to 5 
D)  3 to 30 
A)  1 
B)  2 to 4 
C)  3 to 5 
D)  3 to 30

Question 8

Immunosuppression is used for the maintenance of the transplant.

Accepted Answer

A) True 
 B)False

Question 9

The major histocompatibility complex (MHC)D region codes for ________ molecules.

Accepted Answer

A)  class I 
B)  class II 
C)  class III 
D)  all of the above 
A)  class I 
B)  class II 
C)  class III 
D)  all of the above

Question 10

The most accelerated type of graft rejection is called __________ rejection.

Accepted Answer

A)  hyperacute 
B)  acute 
C)  chronic 
D)  delayed 
A)  hyperacute 
B)  acute 
C)  chronic 
D)  delayed

Question 11

Potential graft-versus-host disease (GVHD)has all the following factor requirements except:

Accepted Answer

A)  a source of immunocompetent T lymphocytes. 
B)  a source of immunocompetent B lymphocytes. 
C)  age of the blood product. 
D)  inability to reject donor cells. 
A)  a source of immunocompetent T lymphocytes. 
B)  a source of immunocompetent B lymphocytes. 
C)  age of the blood product. 
D)  inability to reject donor cells.

Question 12

MATCHING
Match the terms with the appropriate definition.

-Xenograft

Accepted Answer

A) Graft between individuals of different species (e.g. ,pig heart valve to a human heart) 
B) Graft transferred from one position to another in the same individual (e.g. ,skin,hair,bone) 
C) Graft between genetically different recipient and donor of the same species;grafted donor tissue or organ contains antigens not present in recipient 
D) Graft transplanted between different but identical recipient and donor (e.g. ,kidney transplant between monozygous twins) 
A) Graft between individuals of different species (e.g. ,pig heart valve to a human heart) 
B) Graft transferred from one position to another in the same individual (e.g. ,skin,hair,bone) 
C) Graft between genetically different recipient and donor of the same species;grafted donor tissue or organ contains antigens not present in recipient 
D) Graft transplanted between different but identical recipient and donor (e.g. ,kidney transplant between monozygous twins)

Question 13

HLA-B27 antigen is the only HLA antigen with a disease association strong enough to be useful in the differential diagnosis of:

Accepted Answer

A)  Reiter's syndrome. 
B)  juvenile chronic arthritis with spinal involvement. 
C)  anterior uveitis. 
D)  ankylosing spondylitis. 
A)  Reiter's syndrome. 
B)  juvenile chronic arthritis with spinal involvement. 
C)  anterior uveitis. 
D)  ankylosing spondylitis.

Question 14

Immunosuppression is used for induction (intense immunosuppression in the initial days after transplantation).

Accepted Answer

A) True 
 B)False

Question 15

The stronger the antigen difference,the more severe the graft-versus-host reaction.

Accepted Answer

A) True 
 B)False

Question 16

Corneas can be easily transplanted from one human to another because the cornea is:

Accepted Answer

A)  weakly antigenic. 
B)  avascular. 
C)  nonantigenic. 
D)  both a and b 
A)  weakly antigenic. 
B)  avascular. 
C)  nonantigenic. 
D)  both a and b

Question 17

Which of the following antigens is an MHC class II antigen?

Accepted Answer

A)  HLA-A 
B)  HLA-DQ 
C)  HLA-DR 
D)  both b and c 
A)  HLA-A 
B)  HLA-DQ 
C)  HLA-DR 
D)  both b and c

Question 18

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD).

-Infants receiving intrauterine transfusions,followed by exchange transfusions,and possibly infants receiving only exchange transfusions

Accepted Answer

A) High-risk patients 
B) Intermediate-risk patients 
C) Low-risk patients 
A) High-risk patients 
B) Intermediate-risk patients 
C) Low-risk patients

Question 19

The major histocompatibility complex (MHC)is located on:

Accepted Answer

A)  chromosome 3. 
B)  chromosome 6. 
C)  chromosome 21. 
D)  chromosome 22. 
A)  chromosome 3. 
B)  chromosome 6. 
C)  chromosome 21. 
D)  chromosome 22.

Question 20

Class II transplant antigens are expressed on:

Accepted Answer

A)  B lymphocytes. 
B)  activated T lymphocytes. 
C)  macrophages. 
D)  all of the above. 
A)  B lymphocytes. 
B)  activated T lymphocytes. 
C)  macrophages. 
D)  all of the above.

Exam 31: Solid Organ Transplantation

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD). -Recipients of autologous or allogeneic bone marrow grafts

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD). -Patients with aplastic anemia receiving antithymocyte globulin

MATCHING Match the terms with the appropriate definition. -Syngraft

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD). -Children with severe congenital immunodeficiency syndromes involving T lymphocytes

Immunosuppression is used for the suppression of established rejection.

Which of the following classes of MHC antigens is necessary for antigen recognition by CD4+ T lymphocytes?

In posttransfusion graft-versus-host reaction,symptoms begin within ________ day(s)after transfusion.

Immunosuppression is used for the maintenance of the transplant.

The major histocompatibility complex (MHC)D region codes for ________ molecules.

The most accelerated type of graft rejection is called __________ rejection.

Potential graft-versus-host disease (GVHD)has all the following factor requirements except:

MATCHING Match the terms with the appropriate definition. -Xenograft

HLA-B27 antigen is the only HLA antigen with a disease association strong enough to be useful in the differential diagnosis of:

Immunosuppression is used for induction (intense immunosuppression in the initial days after transplantation).

The stronger the antigen difference,the more severe the graft-versus-host reaction.

Corneas can be easily transplanted from one human to another because the cornea is:

Which of the following antigens is an MHC class II antigen?

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD). -Infants receiving intrauterine transfusions,followed by exchange transfusions,and possibly infants receiving only exchange transfusions

The major histocompatibility complex (MHC)is located on:

Class II transplant antigens are expressed on:

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Point-Of-Care Testing

Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Automated Procedures

Molecular Techniques

The Immune Response in Infectious Diseases

A Primer on Vaccines

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Cytomegalovirus

Infectious Mononucleosis

Viral Hepatitis

Rubella and Rubeola Infections

Acquired Immunodeficiency Syndrome

Hypersensitivity Reactions

Immunoproliferative Disorders

Autoimmune Disorders

Systemic Lupus Erythematosus

Rheumatoid Arthritis

Bone Marrow Transplantation

Tumor Immunology

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