Methylation of guanine to produce O6-methylguanine (mG)results in what change to DNA?

A) mG frequently pairs with thymine resulting in a GC $\rarr$ AT mutation B) mG loses its methoxy group resulting in hydrogen bonding with adenine and a bulge in the double helix C) mG is prone to deamination and eventually, depurination D) repair of mG adducts uses a radical mechanism that has the potential to further damage adjacent bases, particularly thymine E) none of the above A) mG frequently pairs with thymine resulting in a GC $\rarr$ AT mutation B) mG loses its methoxy group resulting in hydrogen bonding with adenine and a bulge in the double helix C) mG is prone to deamination and eventually, depurination D) repair of mG adducts uses a radical mechanism that has the potential to further damage adjacent bases, particularly thymine E) none of the above

Exam 26: DNA Restructuring: Repair, Recombination, Rearrangement, Amplification

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In order for lysogeny to occur, the enzyme ______________ must insert the phage DNA into a specific site in the bacterial chromosome.

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What role does integration host factor (IHF)play in site-specific recombination during phage $\lambda$ lysogeny?

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What is a common trigger for the bacterial SOS response?

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Which of the following coenzymes forms the photochemical reaction center of DNA photolyase?

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Question 4

Methylation of guanine to produce O⁶-methylguanine (mG)results in what change to DNA?

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Question 5

The repair of a double-strand break can be accomplished by , which requires the Ku70/80 protein to _________.

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Question 6

Which of the following types of DNA repair is often coupled with transcription?

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Question 7

Which is a possible outcome when guanine is oxidized to 8-oxoguanine in the following segment of DNA?

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Question 8

In antibody light chain production, combination of V and J regions occurs at the _ level; combination of J and C regions occurs at the _ level.

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Question 9

One mechanism to introduce greater diversity into antibody sequences is somatic hypermutation. What enzyme is responsible for somatic hypermutation in the DNA sequences that code for antibodies?

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Question 10

In mismatch repair coupled to replication, which of the following relates a correct sequence of events?

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Question 11

Using the following DNA segment, show how microsatellite instability is present through a 2-base deletion as a result of loop creation within the A-C repeating sequence. Give the sequence after the first round of replication (with loop)and after the second round of replication. Template strand: 3'-C-A-C-A-C-A-C-A-C-A-5'

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Question 12

Which of the following transposable elements is correctly defined?

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Question 13

Which of the following the represents the correct sequence of events for the Holiday model of homologous recombination?

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Question 14

A transposable element in a eukaryotic cell is called a _____________.

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Question 15

Given the following DNA segments, show the intermediate structure that would be produced following isomerization during homologous recombination.

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Question 16

Which of the following is formed by oxidation of a DNA base?

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Question 17

The introduction of DNA into a bacterial cell by first packaging the DNA into a phage particle is referred to as _____________.

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Question 18

Using the figure below, what is the first bond broken in the base excision repair process?

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Question 19

Which base or bases is/are methylated to identify the original template strand of replicated DNA?

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Question 20

Showing 1 - 20 of 25

Exam 26: DNA Restructuring: Repair, Recombination, Rearrangement, Amplification

In order for lysogeny to occur, the enzyme ______________ must insert the phage DNA into a specific site in the bacterial chromosome.

What role does integration host factor (IHF)play in site-specific recombination during phage λ\lambdaλ lysogeny?

What is a common trigger for the bacterial SOS response?

Which of the following coenzymes forms the photochemical reaction center of DNA photolyase?

Methylation of guanine to produce O6-methylguanine (mG)results in what change to DNA?

The repair of a double-strand break can be accomplished by ______________, which requires the Ku70/80 protein to _______________________.

Which of the following types of DNA repair is often coupled with transcription?

Which is a possible outcome when guanine is oxidized to 8-oxoguanine in the following segment of DNA?

In antibody light chain production, combination of V and J regions occurs at the _____ level; combination of J and C regions occurs at the _____ level.

One mechanism to introduce greater diversity into antibody sequences is somatic hypermutation. What enzyme is responsible for somatic hypermutation in the DNA sequences that code for antibodies?

In mismatch repair coupled to replication, which of the following relates a correct sequence of events?

Which of the following transposable elements is correctly defined?

Which of the following the represents the correct sequence of events for the Holiday model of homologous recombination?

A transposable element in a eukaryotic cell is called a _____________.

Given the following DNA segments, show the intermediate structure that would be produced following isomerization during homologous recombination.

Which of the following is formed by oxidation of a DNA base?

The introduction of DNA into a bacterial cell by first packaging the DNA into a phage particle is referred to as _____________.

Using the figure below, what is the first bond broken in the base excision repair process?

Which base or bases is/are methylated to identify the original template strand of replicated DNA?

The Scope of Biochemistry

The Matrix of Life: Weak Interactions in an Aqueous Environment

The Energetics of Life

Nucleic Acids

Introduction to Proteins: the Primary Level of Protein Structure

The Three-Dimensional Structure of Proteins

Protein Function and Evolution

Contractile Proteins and Molecular Motors

Carbohydrates: Sugars, Saccharides, Glycans

Lipids, Membranes and Cellular Transport

Enzymes: Biological Catalysts

Chemical Logic of Metabolism

Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway

Citric Acid Cycle and Glyoxylate Cycle

Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism

Photosynthesis

Lipid Metabolism I: Fatty Acids, Triacylglycerols, and Lipoproteins

Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates

Lipid Metabolism Ii: Membrane Lipids, Steroids, Isoprenoids, and Eicosanoids

Metabolism of Nitrogenous Compounds I: Principles of Biosynthesis, Utilization, and Turnover

Metabolism of Nitogenous Compounds II: Amino Acids, Porphyrins, and Neurotransmitters

Nucleotide Metabolism

Mechanisms of Signal Transduction

Genes, Genomes and Chromosomes

DNA Replication

Information Readout: Transcription and Post-Transcriptional Processing

Information Decoding: Translation and Post-Translational Protein Processing

Regulation of Gene Expression

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What role does integration host factor (IHF)play in site-specific recombination during phage $\lambda$ lysogeny?

Methylation of guanine to produce O⁶-methylguanine (mG)results in what change to DNA?

The repair of a double-strand break can be accomplished by , which requires the Ku70/80 protein to _________.

In antibody light chain production, combination of V and J regions occurs at the _ level; combination of J and C regions occurs at the _ level.