Question 1

Which of the following is not included within the nucleus of a typical interphase (nonmitotic)cell?

Accepted Answer

A) chromosomes 
B) nuclear matrix 
C) nucleolus 
D) nucleoplasm 
E) mesosome 
A) chromosomes 
B) nuclear matrix 
C) nucleolus 
D) nucleoplasm 
E) mesosome

Question 2

What evidence suggests that while the XIST gene may be required to initiate X chromosome inactivation,it may not be required to maintain it from one generation to another?

Accepted Answer

A) Tumor cells do not maintain X chromosome inactivation from generation to generation. 
B) Some tumor cells in women contain inactivated X chromosomes whose XIST gene has been deleted. 
C) Some tumor cells in women contain inactivated X chromosomes whose XIST gene has been duplicated. 
D) Some women have patches of cells in their retinas that are color blind and others that are not. 
E) Some tumor cells in women have no X chromosomes. 
A) Tumor cells do not maintain X chromosome inactivation from generation to generation. 
B) Some tumor cells in women contain inactivated X chromosomes whose XIST gene has been deleted. 
C) Some tumor cells in women contain inactivated X chromosomes whose XIST gene has been duplicated. 
D) Some women have patches of cells in their retinas that are color blind and others that are not. 
E) Some tumor cells in women have no X chromosomes.

Question 3

How are DNA microarrays used to analyze gene expression?

Accepted Answer

DNA microarrays may be used to detect ch

Question 4

Each transcription factor usually has at least two domains that mediate different aspects of their function.What are they?

Accepted Answer

A) the DNA-binding domain and the activation domain 
B) the activation domain and the repression domain 
C) the DNA-binding domain and the repression domain 
D) the RNA-binding domain and the activation domain 
E) the RNA-binding domain and the repression domain 
A) the DNA-binding domain and the activation domain 
B) the activation domain and the repression domain 
C) the DNA-binding domain and the repression domain 
D) the RNA-binding domain and the activation domain 
E) the RNA-binding domain and the repression domain

Question 5

What evidence would suggest that histone acetylation provides a recognizable surface to recruit proteins that bind to acetylated histones?

Accepted Answer

A) Mutation of a lysine in the tail of histone H3 in a promoter region to an alanine,which cannot be acetylated,prevents the binding of transcription factors that normally bind to that promoter. 
B) Lysines interfere with the binding of transcription factors to histone H3K9. 
C) Alanines bind to transcription factors very tightly. 
D) Histone H3K9 cannot be acetylated and therefore does not bind transcription factors. 
E) Acetylation of histone H3K9 inhibits binding of transcription factors. 
A) Mutation of a lysine in the tail of histone H3 in a promoter region to an alanine,which cannot be acetylated,prevents the binding of transcription factors that normally bind to that promoter. 
B) Lysines interfere with the binding of transcription factors to histone H3K9. 
C) Alanines bind to transcription factors very tightly. 
D) Histone H3K9 cannot be acetylated and therefore does not bind transcription factors. 
E) Acetylation of histone H3K9 inhibits binding of transcription factors.

Question 6

Messenger RNA editing is an example of gene expression at the _________ level.

Accepted Answer

A) transcriptional 
B) translational 
C) posttranslational 
D) posttranscriptional 
E) preternatural 
A) transcriptional 
B) translational 
C) posttranslational 
D) posttranscriptional 
E) preternatural

Question 7

In mRNA editing,to which nitrogenous bases is adenine converted by the enzymatic removal of an amino group?

Accepted Answer

A) cytosine 
B) inosine 
C) guanine 
D) thymine 
E) uracil 
A) cytosine 
B) inosine 
C) guanine 
D) thymine 
E) uracil

Question 8

What is the name of the gene that makes the RNA thought to be responsible for the inactivation if the X chromosome?

Accepted Answer

A) INAC 
B) XIST 
C) 1STX 
D) IRS 
E) XCHR 
A) INAC 
B) XIST 
C) 1STX 
D) IRS 
E) XCHR

Question 9

In gene expression profiling by microarray analysis,____ sequences produced from mRNA are hybridized with ____ sequences that have been spotted onto a glass slide.

Accepted Answer

A) cDNA,complementary 
B) cDNA,identical 
C) RNA,complementary 
D) intron,exon 
E) short,long 
A) cDNA,complementary 
B) cDNA,identical 
C) RNA,complementary 
D) intron,exon 
E) short,long

Question 10

The $\alpha$-helical portions of the bZip proteins ______.

Accepted Answer

A) facilitate dimerization 
B) allow the protein to recognize a specific nucleotide sequence in DNA 
C) prevent dimerization 
D) allow the protein to recognize a specific nucleotide sequence in RNA 
E) facilitate tetramerization 
A) facilitate dimerization 
B) allow the protein to recognize a specific nucleotide sequence in DNA 
C) prevent dimerization 
D) allow the protein to recognize a specific nucleotide sequence in RNA 
E) facilitate tetramerization

Question 11

You attempt deletion mapping of a part of the promoter region of a particular gene.You remove a short sequence of nucleotides.Once the altered DNA is transfected into cells,the cells are able to transcribe the transfected DNA in a normal fashion.What do you conclude?

Accepted Answer

A) The sequence that was removed is an essential part of the promoter. 
B) The sequence that was deleted is an important determinant of the ability to transcribe the gene. 
C) The sequence that was removed is not an essential part of the promoter. 
D) The deleted sequence has a moderate level of importance in promoting transcription. 
E) The deleted sequence binds tightly to RNA polymerase. 
A) The sequence that was removed is an essential part of the promoter. 
B) The sequence that was deleted is an important determinant of the ability to transcribe the gene. 
C) The sequence that was removed is not an essential part of the promoter. 
D) The deleted sequence has a moderate level of importance in promoting transcription. 
E) The deleted sequence binds tightly to RNA polymerase.

Question 12

The fact that chromosomes should become shorter and shorter with each round of cell division is referred to as the ________.

Accepted Answer

A) shortening contradiction 
B) the replication paradox 
C) the short end hypothesis 
D) the truncated end problem 
E) the end-replication problem 
A) shortening contradiction 
B) the replication paradox 
C) the short end hypothesis 
D) the truncated end problem 
E) the end-replication problem

Question 13

Treatment of fragmented DNA with a particular transcription factor attached at a number of sites with antibodies against that transcription factor will cause _________.

Accepted Answer

A) precipitation of DNA fragments bound to that transcription factor 
B) solubilization of DNA fragments bound to that transcription factor 
C) hydrolysis of DNA fragments bound to that transcription factor 
D) hydrolysis of DNA fragments that remain unbound by that transcription factor 
E) precipitation of DNA fragments not bound to that transcription factor 
A) precipitation of DNA fragments bound to that transcription factor 
B) solubilization of DNA fragments bound to that transcription factor 
C) hydrolysis of DNA fragments bound to that transcription factor 
D) hydrolysis of DNA fragments that remain unbound by that transcription factor 
E) precipitation of DNA fragments not bound to that transcription factor

Question 14

The basic amino acid stretch in bZip proteins _______.

Accepted Answer

A) facilitates dimerization 
B) allows the protein to recognize a specific nucleotide sequence in DNA 
C) prevents dimerization 
D) allows the protein to recognize a specific nucleotide sequence in RNA 
E) facilitates tetramerization 
A) facilitates dimerization 
B) allows the protein to recognize a specific nucleotide sequence in DNA 
C) prevents dimerization 
D) allows the protein to recognize a specific nucleotide sequence in RNA 
E) facilitates tetramerization

Question 15

What may happen if a protein that is supposed to have a short survival time and that is involved in the initiation of cell division is not destroyed when it is supposed to be destroyed?

Accepted Answer

A) The cell may die quickly. 
B) The cells may become malignant. 
C) The cells may become benign. 
D) The cell may stop dividing but survive. 
E) The cell may undergo apoptosis. 
A) The cell may die quickly. 
B) The cells may become malignant. 
C) The cells may become benign. 
D) The cell may stop dividing but survive. 
E) The cell may undergo apoptosis.

Question 16

How do allolactose and lactose differ?

Accepted Answer

A) They are composed of different sugars. 
B) Allolactose has a negative charge,while lactose has a positive charge. 
C) The type of linkage holding the two constituent sugars together differs between lactose and allolactose. 
D) The order of the sugars is reversed in the two molecules. 
E) The constituent sugars are both upside down in lactose and right-side-up in allolactose. 
A) They are composed of different sugars. 
B) Allolactose has a negative charge,while lactose has a positive charge. 
C) The type of linkage holding the two constituent sugars together differs between lactose and allolactose. 
D) The order of the sugars is reversed in the two molecules. 
E) The constituent sugars are both upside down in lactose and right-side-up in allolactose.

Question 17

The thin filamentous meshwork within the nucleus that is bound by integral membrane proteins of the inner surface of the nuclear envelope in animal cells is called the _________.

Accepted Answer

A) basement lamina 
B) basal lamina 
C) nuclear lamina 
D) nucleon 
E) nuclear limulus 
A) basement lamina 
B) basal lamina 
C) nuclear lamina 
D) nucleon 
E) nuclear limulus

Question 18

With what structure is the outer membrane of the nuclear envelope continuous?

Accepted Answer

A) RER 
B) SER 
C) Golgi complex 
D) the spindle 
E) the plasma membrane 
A) RER 
B) SER 
C) Golgi complex 
D) the spindle 
E) the plasma membrane

Question 19

Why was it initially expected that cloned animals might have a shorter life span?

Accepted Answer

A) The chromosomes of the donor nuclei had shortened telomeres. 
B) The chromosomes of the donor nuclei had lengthened telomeres. 
C) The egg cell had elevated telomerase. 
D) The donor cell had elevated telomerase. 
E) After transplant of the nucleus,telomerase levels climbed precipitously. 
A) The chromosomes of the donor nuclei had shortened telomeres. 
B) The chromosomes of the donor nuclei had lengthened telomeres. 
C) The egg cell had elevated telomerase. 
D) The donor cell had elevated telomerase. 
E) After transplant of the nucleus,telomerase levels climbed precipitously.

Question 20

What level of control of gene expression is defined as regulating whether or not a particular mRNA is actually used in protein synthesis and,if so,how long and for how long a period of time?

Accepted Answer

A) transcriptional-level controls 
B) processing-level controls 
C) translational-level controls 
D) replication-level controls 
E) denaturation-level controls 
A) transcriptional-level controls 
B) processing-level controls 
C) translational-level controls 
D) replication-level controls 
E) denaturation-level controls

Which of the following is not included within the nucleus of a typical interphase (nonmitotic)cell?

What evidence suggests that while the XIST gene may be required to initiate X chromosome inactivation,it may not be required to maintain it from one generation to another?

How are DNA microarrays used to analyze gene expression?

Each transcription factor usually has at least two domains that mediate different aspects of their function.What are they?

What evidence would suggest that histone acetylation provides a recognizable surface to recruit proteins that bind to acetylated histones?

Messenger RNA editing is an example of gene expression at the _________ level.

In mRNA editing,to which nitrogenous bases is adenine converted by the enzymatic removal of an amino group?

What is the name of the gene that makes the RNA thought to be responsible for the inactivation if the X chromosome?

In gene expression profiling by microarray analysis, sequences produced from mRNA are hybridized with sequences that have been spotted onto a glass slide.

The $\alpha$ -helical portions of the bZip proteins ______.

You attempt deletion mapping of a part of the promoter region of a particular gene.You remove a short sequence of nucleotides.Once the altered DNA is transfected into cells,the cells are able to transcribe the transfected DNA in a normal fashion.What do you conclude?

The fact that chromosomes should become shorter and shorter with each round of cell division is referred to as the ________.

Treatment of fragmented DNA with a particular transcription factor attached at a number of sites with antibodies against that transcription factor will cause _________.

The basic amino acid stretch in bZip proteins _______.

What may happen if a protein that is supposed to have a short survival time and that is involved in the initiation of cell division is not destroyed when it is supposed to be destroyed?

How do allolactose and lactose differ?

The thin filamentous meshwork within the nucleus that is bound by integral membrane proteins of the inner surface of the nuclear envelope in animal cells is called the _________.

With what structure is the outer membrane of the nuclear envelope continuous?

Why was it initially expected that cloned animals might have a shorter life span?

What level of control of gene expression is defined as regulating whether or not a particular mRNA is actually used in protein synthesis and,if so,how long and for how long a period of time?

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics,enzymes and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

Cancer

The Immune Response

Techniques in Cell and Molecular Biology

Filters

Exam 12: Control of Gene Expression

Which of the following is not included within the nucleus of a typical interphase (nonmitotic)cell?

What evidence suggests that while the XIST gene may be required to initiate X chromosome inactivation,it may not be required to maintain it from one generation to another?

How are DNA microarrays used to analyze gene expression?

Each transcription factor usually has at least two domains that mediate different aspects of their function.What are they?

What evidence would suggest that histone acetylation provides a recognizable surface to recruit proteins that bind to acetylated histones?

Messenger RNA editing is an example of gene expression at the _________ level.

In mRNA editing,to which nitrogenous bases is adenine converted by the enzymatic removal of an amino group?

What is the name of the gene that makes the RNA thought to be responsible for the inactivation if the X chromosome?

In gene expression profiling by microarray analysis,____ sequences produced from mRNA are hybridized with ____ sequences that have been spotted onto a glass slide.

The α\alphaα -helical portions of the bZip proteins ______.

You attempt deletion mapping of a part of the promoter region of a particular gene.You remove a short sequence of nucleotides.Once the altered DNA is transfected into cells,the cells are able to transcribe the transfected DNA in a normal fashion.What do you conclude?

The fact that chromosomes should become shorter and shorter with each round of cell division is referred to as the ________.

Treatment of fragmented DNA with a particular transcription factor attached at a number of sites with antibodies against that transcription factor will cause _________.

The basic amino acid stretch in bZip proteins _______.

What may happen if a protein that is supposed to have a short survival time and that is involved in the initiation of cell division is not destroyed when it is supposed to be destroyed?

How do allolactose and lactose differ?

The thin filamentous meshwork within the nucleus that is bound by integral membrane proteins of the inner surface of the nuclear envelope in animal cells is called the _________.

With what structure is the outer membrane of the nuclear envelope continuous?

Why was it initially expected that cloned animals might have a shorter life span?

What level of control of gene expression is defined as regulating whether or not a particular mRNA is actually used in protein synthesis and,if so,how long and for how long a period of time?

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics,enzymes and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

Cancer

The Immune Response

Techniques in Cell and Molecular Biology

Filters

In gene expression profiling by microarray analysis, sequences produced from mRNA are hybridized with sequences that have been spotted onto a glass slide.

The $\alpha$ -helical portions of the bZip proteins ______.