Question 1

Macrolide antibiotics are metabolized by:

Accepted Answer

A) Attaching to bile and elimination in feces. 
B) Enzymatic activity by acetyltransferase to an inactive metabolite. 
C) Glomerular filtration into the urine. 
D) The cytochrome P-450 system. 
A) Attaching to bile and elimination in feces. 
B) Enzymatic activity by acetyltransferase to an inactive metabolite. 
C) Glomerular filtration into the urine. 
D) The cytochrome P-450 system.

Question 2

Fluoroquinolones have been associated with which effect?

Accepted Answer

A) Transient increase in liver enzymes 
B) Increase in potassium 
C) Prolongation of the QT interval 
D) Serum sickness 
A) Transient increase in liver enzymes 
B) Increase in potassium 
C) Prolongation of the QT interval 
D) Serum sickness

Question 3

Aminoglycosides are ineffective against which of the following organisms?

Accepted Answer

A) Gram-negative bacilli 
B) Enteric bacilli 
C) Gram-positive cocci 
D) Anaerobic bacteria 
A) Gram-negative bacilli 
B) Enteric bacilli 
C) Gram-positive cocci 
D) Anaerobic bacteria

Question 4

Which of the following drugs inhibits the hepatic metabolism of digoxin?

Accepted Answer

A) ampicillin 
B) clarithromycin (Biaxin) 
C) metronidazole (Flagyl) 
D) tetracycline (Achromycin V) 
A) ampicillin 
B) clarithromycin (Biaxin) 
C) metronidazole (Flagyl) 
D) tetracycline (Achromycin V)

Question 5

Which of the following is the drug of choice for postexposure prophylaxis and treatment of Bacillus anthracis provided there are no contraindications?

Accepted Answer

A) ciprofloxacin (Cipro) 
B) norfloxacin (Noroxin) 
C) levofloxacin (Levaquin) 
D) penicillin 
A) ciprofloxacin (Cipro) 
B) norfloxacin (Noroxin) 
C) levofloxacin (Levaquin) 
D) penicillin

Question 6

Which of the following drugs has been associated with serum sickness?

Accepted Answer

A) clarithromycin (Biaxin) 
B) tetracycline (Achromycin V) 
C) cefaclor (Ceclor) 
D) clindamycin (Cleocin) 
A) clarithromycin (Biaxin) 
B) tetracycline (Achromycin V) 
C) cefaclor (Ceclor) 
D) clindamycin (Cleocin)

Question 7

Sulfonamides may interact with sulfonylureas,causing which of the following reactions?

Accepted Answer

A) Hypokalemia 
B) Hypoglycemia 
C) Diabetic ketoacidosis 
D) Hyperglycemia 
A) Hypokalemia 
B) Hypoglycemia 
C) Diabetic ketoacidosis 
D) Hyperglycemia

Question 8

When prescribing doxycycline (Vibramycin),patients should be advised of which of the following?

Accepted Answer

A) Stay out of direct sunlight. 
B) Drink 8 to 10 glasses of fluid per day. 
C) Watch for signs of blood dyscrasia. 
D) Take the drug 1 or 2 hours before meals. 
A) Stay out of direct sunlight. 
B) Drink 8 to 10 glasses of fluid per day. 
C) Watch for signs of blood dyscrasia. 
D) Take the drug 1 or 2 hours before meals.

Question 9

The treatment of tuberculosis requires multiple drug therapy for a period of:

Accepted Answer

A) 1 month. 
B) 2 months. 
C) 4 months. 
D) 6 months. 
A) 1 month. 
B) 2 months. 
C) 4 months. 
D) 6 months.

Question 10

Which of the following can be administered for antibiotic-associated Clostridium difficile colitis that is resistant to metronidazole?

Accepted Answer

A) clindamycin (Cleocin) 
B) doxycycline (Vibramycin) 
C) vancomycin (Vancocyn) 
D) cefaclor (Ceclor) 
A) clindamycin (Cleocin) 
B) doxycycline (Vibramycin) 
C) vancomycin (Vancocyn) 
D) cefaclor (Ceclor)

Question 11

First-generation cephalosporins are best used against which of the following organisms?

Accepted Answer

A) Gram-negative rods 
B) Gram-positive cocci 
C) Yeasts and fungi 
D) Anaerobes 
A) Gram-negative rods 
B) Gram-positive cocci 
C) Yeasts and fungi 
D) Anaerobes

Question 12

When "clavulanate" is added to amoxicillin,the combination offers clinicians which of the following?

Accepted Answer

A) A wider spectrum of activity than amoxicillin used alone 
B) A narrower "spectrum of activity" than amoxicillin used alone 
C) An agent able to combat anaerobes 
D) An agent with a longer half-life,hence a longer dosing interval 
A) A wider spectrum of activity than amoxicillin used alone 
B) A narrower "spectrum of activity" than amoxicillin used alone 
C) An agent able to combat anaerobes 
D) An agent with a longer half-life,hence a longer dosing interval

Question 13

When taking fluoroquinolones,which of the following products should be avoided because it may interfere with absorption of the antibiotics?

Accepted Answer

A) aspirin 
B) antacids 
C) acetaminophen 
D) Altoids 
A) aspirin 
B) antacids 
C) acetaminophen 
D) Altoids

Question 14

Hemolytic anemia may be encountered in patients with glucose 6-phosphate dehydrogenase deficiency when they take which of the following drugs?

Accepted Answer

A) penicillin 
B) sulfasalazine (Azulfidine) 
C) cefoxitin (Mefoxin) 
D) clindamycin (Cleocin) 
A) penicillin 
B) sulfasalazine (Azulfidine) 
C) cefoxitin (Mefoxin) 
D) clindamycin (Cleocin)

Question 15

Which of the following is a member of monobactam antibiotics?

Accepted Answer

A) aztreonam (Azactam) 
B) azithromycin (Zithromax) 
C) amikacin (Amikin) 
D) ampicillin 
A) aztreonam (Azactam) 
B) azithromycin (Zithromax) 
C) amikacin (Amikin) 
D) ampicillin

Question 16

Staphylococcus pneumoniae remains a difficult infection to treat because of its growing resistance to which of the following?

Accepted Answer

A) Penicillins and cephalosporins 
B) Aminoglycosides 
C) Tetracyclines 
D) Sulfonamides 
A) Penicillins and cephalosporins 
B) Aminoglycosides 
C) Tetracyclines 
D) Sulfonamides

Question 17

Which of the following would be prescribed for a patient with "atypical pneumonia" or a chlamydial infection?

Accepted Answer

A) fluconazole (Diflucan) 
B) azithromycin (Zithromax,Z-Pak) 
C) flucytosine (Ancobon) 
D) clarithromycin (Biaxin) 
A) fluconazole (Diflucan) 
B) azithromycin (Zithromax,Z-Pak) 
C) flucytosine (Ancobon) 
D) clarithromycin (Biaxin)

Question 18

Which of the following is a side effect of clindamycin (Cleocin)?

Accepted Answer

A) Ototoxicity 
B) Pseudomembranous colitis 
C) Hyperglycemia 
D) Crystalluria 
A) Ototoxicity 
B) Pseudomembranous colitis 
C) Hyperglycemia 
D) Crystalluria

Question 19

Imipenem is typically given with which other drug because when given alone it is rapidly metabolized in the tubules of the kidneys,rendering it ineffective?

Accepted Answer

A) cilastatin 
B) amoxicillin 
C) erythromycin 
D) vancomycin 
A) cilastatin 
B) amoxicillin 
C) erythromycin 
D) vancomycin

Question 20

Which drug is an antibiotic that inhibits the synthesis of folate,which is a critical component in the making of microbial DNA?

Accepted Answer

A) clindamycin (Cleocin) 
B) cephalexin (Keflex) 
C) tetracycline (Achromycin V) 
D) sulfamethoxazole (Gantanol) 
A) clindamycin (Cleocin) 
B) cephalexin (Keflex) 
C) tetracycline (Achromycin V) 
D) sulfamethoxazole (Gantanol)

Exam 17: Modern Approaches to Managing Bacterial Infections

Macrolide antibiotics are metabolized by:

Fluoroquinolones have been associated with which effect?

Aminoglycosides are ineffective against which of the following organisms?

Which of the following drugs inhibits the hepatic metabolism of digoxin?

Which of the following is the drug of choice for postexposure prophylaxis and treatment of Bacillus anthracis provided there are no contraindications?

Which of the following drugs has been associated with serum sickness?

Sulfonamides may interact with sulfonylureas,causing which of the following reactions?

When prescribing doxycycline (Vibramycin),patients should be advised of which of the following?

The treatment of tuberculosis requires multiple drug therapy for a period of:

Which of the following can be administered for antibiotic-associated Clostridium difficile colitis that is resistant to metronidazole?

First-generation cephalosporins are best used against which of the following organisms?

When "clavulanate" is added to amoxicillin,the combination offers clinicians which of the following?

When taking fluoroquinolones,which of the following products should be avoided because it may interfere with absorption of the antibiotics?

Hemolytic anemia may be encountered in patients with glucose 6-phosphate dehydrogenase deficiency when they take which of the following drugs?

Which of the following is a member of monobactam antibiotics?

Staphylococcus pneumoniae remains a difficult infection to treat because of its growing resistance to which of the following?

Which of the following would be prescribed for a patient with "atypical pneumonia" or a chlamydial infection?

Which of the following is a side effect of clindamycin (Cleocin)?

Imipenem is typically given with which other drug because when given alone it is rapidly metabolized in the tubules of the kidneys,rendering it ineffective?

Which drug is an antibiotic that inhibits the synthesis of folate,which is a critical component in the making of microbial DNA?

Conscientious and Rational Prescribing in the 21st Century

An Introduction to Pharmacodynamics and Pharmacokinetics

Communicating With Patients About Medications: a Patient-Centered Approach

Drugs Used in the Treatment of Bone and Joint Disorders

Drugs Used in the Treatment of Eye and Ear Disorders

Drugs Used in the Treatment of Cardiovascular Disorders

Drugs Used to Regulate Blood Pressure

Drugs Used in the Treatment of Hyperlipidemias

Drugs Used in the Treatment of Blood Disorders

Drugs Used in the Treatment of Pulmonary Diseases and Disorders

Drugs Used in the Treatment of Common Disorders of the Gastrointestinal System

Drugs Used to Treat Endocrine Gland Disorders

Drugs Used in the Treatment of Diabetes Mellitus

Drugs Used to Treat Common Neurological Conditions

Practical Pharmacotherapy of Drugs Used to Treat Psychiatric Disorders

Drugs Used in the Treatment of Skin Disorders

Drugs Used in the Treatment of Nonbacterial Infections

Drugs Used in the Treatment of Neoplasms

Drugs Used to Affect Womens Health

Drugs Used to Affect Mens Health

Prescribing for the Geriatric Patient

Prescribing for the Pediatric Patient

Drugs Used to Manage Pain

The Integrative Medicine Pharmacopoeia: Herbals, vitamins, and Dietary Supplements

Agents Used to Manipulate the Immune Response

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