Question 1

An immunogen is a(n)

Accepted Answer

A) compound that is capable of eliciting an immune response in a host 
B) antigen that is from other members of the same species as the host 
C) restricted portion of a molecule involved in the actual binding with the combining site of a particular antibody 
D) small compound that, although able to combine with elements of the immune system such as antibodies, cannot stimulate an immune response unless they are linked to a much larger immunogenic molecule called a carrier 
A) compound that is capable of eliciting an immune response in a host 
B) antigen that is from other members of the same species as the host 
C) restricted portion of a molecule involved in the actual binding with the combining site of a particular antibody 
D) small compound that, although able to combine with elements of the immune system such as antibodies, cannot stimulate an immune response unless they are linked to a much larger immunogenic molecule called a carrier A

Question 2

An antigen on an intracellular bacteria

Accepted Answer

A) is presented after infection by the infected cell in a class I molecule after binding in the Golgi 
B) is presented after ingestion by an antigen-presenting cell after the relevant antigenic peptide has been processed into pieces that are 13-18 amino acids long, and the class II molecule has lost the invariant chain in the lysosome and picked up the processed peptide 
C) is presented after ingestion by an antigen-presenting cell in a class II molecule after binding in the rough endoplasmic reticulum 
D) is presented after ingestion by an antigen-presenting cell after the relevant antigenic peptide has been processed into pieces that are 13-18 amino acids long, and the class I molecule has lost the invariant chain in the lysosome and picked up the processed peptide 
A) is presented after infection by the infected cell in a class I molecule after binding in the Golgi 
B) is presented after ingestion by an antigen-presenting cell after the relevant antigenic peptide has been processed into pieces that are 13-18 amino acids long, and the class II molecule has lost the invariant chain in the lysosome and picked up the processed peptide 
C) is presented after ingestion by an antigen-presenting cell in a class II molecule after binding in the rough endoplasmic reticulum 
D) is presented after ingestion by an antigen-presenting cell after the relevant antigenic peptide has been processed into pieces that are 13-18 amino acids long, and the class I molecule has lost the invariant chain in the lysosome and picked up the processed peptide A

Question 3

Epitopes are the

Accepted Answer

A) part of the antibody molecule that binds to the antigen 
B) part of the antigen that binds to the binding site of the antibody 
C) outermost part of the protein 
D) outermost part of a carbohydrate 
A) part of the antibody molecule that binds to the antigen 
B) part of the antigen that binds to the binding site of the antibody 
C) outermost part of the protein 
D) outermost part of a carbohydrate B

Question 4

An antigen on an extracellular bacterium

Accepted Answer

A) is presented after ingestion by an antigen-presenting cell in a class I molecule after binding in the rough endoplasmic reticulum 
B) is presented after ingestion by an antigen-presenting cell after the relevant antigenic peptide has been processed into pieces that are 13-18 amino acids long and the class II molecule has lost the invariant chain in the lysosome and has picked up the processed peptide 
C) is presented after ingestion by an antigen-presenting cell in a class II molecule after binding in the rough endoplasmic reticulum 
D) is presented after ingestion by an antigen-presenting cell after the relevant antigenic peptide has been processed into pieces that are 13-18 amino acids long, and the class I molecule has lost the invariant chain in the lysosome and has picked up the processed peptide 
A) is presented after ingestion by an antigen-presenting cell in a class I molecule after binding in the rough endoplasmic reticulum 
B) is presented after ingestion by an antigen-presenting cell after the relevant antigenic peptide has been processed into pieces that are 13-18 amino acids long and the class II molecule has lost the invariant chain in the lysosome and has picked up the processed peptide 
C) is presented after ingestion by an antigen-presenting cell in a class II molecule after binding in the rough endoplasmic reticulum 
D) is presented after ingestion by an antigen-presenting cell after the relevant antigenic peptide has been processed into pieces that are 13-18 amino acids long, and the class I molecule has lost the invariant chain in the lysosome and has picked up the processed peptide

Question 5

Which of the following is the most immunogenic?

Accepted Answer

A) Streptococcal polysaccharide 
B) DNA from a hepatitis B virus 
C) the protein toxoid from tetanus 
D) the lipids isolated from the milk of a cow with an udder infection 
A) Streptococcal polysaccharide 
B) DNA from a hepatitis B virus 
C) the protein toxoid from tetanus 
D) the lipids isolated from the milk of a cow with an udder infection

Question 6

An adjuvant is

Accepted Answer

A) a bacterial strain that has undergone a mutation to become worse 
B) a helper virus that allows bacterial growth 
C) a substance that can increase recruitment of cells to participate in an immune response and cause slow release of the antigen 
D) any organism that helps another organism proliferate 
A) a bacterial strain that has undergone a mutation to become worse 
B) a helper virus that allows bacterial growth 
C) a substance that can increase recruitment of cells to participate in an immune response and cause slow release of the antigen 
D) any organism that helps another organism proliferate

Question 7

If mom is HLA A2A9/B5B12/CW3CW5 and baby is A2A11/B5B18/Cw5Cw8, can a man who is A9A11/B8B18/CW5CW8 be the dad? Can a child who is A2A9/B5B18/Cw5Cw8 be the sibling without recombinational events?

Accepted Answer

A) yes and yes 
B) yes and no 
C) no and yes 
D) no and no 
A) yes and yes 
B) yes and no 
C) no and yes 
D) no and no

Question 8

It has been theorized that some viruses have antigens on their surfaces similar to human antigens, which can lead to the reaction of the immune system with self-antigens that are slightly different from the virus as the result of

Accepted Answer

A) homeopathic effect 
B) opsonic effect 
C) cross-reactivity 
D) polyclonal response 
A) homeopathic effect 
B) opsonic effect 
C) cross-reactivity 
D) polyclonal response

Question 9

Which of the following is the most immunogenic?

Accepted Answer

A) Hemophilus influenza polysaccharide 
B) DNA from a Herpes virus 
C) protein toxoid from tetanus 
D) lipids isolated from an atherosclerosis plaque 
A) Hemophilus influenza polysaccharide 
B) DNA from a Herpes virus 
C) protein toxoid from tetanus 
D) lipids isolated from an atherosclerosis plaque

Question 10

Which of the following contains factors involved in immunogenicity?

Accepted Answer

A) charge, foreignness, chemical complexity 
B) molecular weight, foreignness, chemical complexity 
C) charge, foreignness, molecular weight 
D) charge, molecular weight, chemical complexity 
A) charge, foreignness, chemical complexity 
B) molecular weight, foreignness, chemical complexity 
C) charge, foreignness, molecular weight 
D) charge, molecular weight, chemical complexity

Question 11

An alloantigen is

Accepted Answer

A) an antigen from an immunologically privileged site that has been released due to injury 
B) an antigen from a different species 
C) an antigen from another member of the same species 
D) an antigen that is not inherited as expected 
A) an antigen from an immunologically privileged site that has been released due to injury 
B) an antigen from a different species 
C) an antigen from another member of the same species 
D) an antigen that is not inherited as expected

Question 12

Class II molecules

Accepted Answer

A) have a bound invariant chain that must be removed before antigenic peptides can bind 
B) present antigen to CD4 + T cells 
C) present antigen to CD8+ T cells 
D) A and B 
A) have a bound invariant chain that must be removed before antigenic peptides can bind 
B) present antigen to CD4 + T cells 
C) present antigen to CD8+ T cells 
D) A and B

Question 13

An exogenous antigen is defined as

Accepted Answer

A) any foreign antigen presented to a T cell 
B) an alloantigen presented to a B cell 
C) an antigen that comes from outside the cell and has been engulfed by an antigen-presenting cell 
D) an antigen that comes from an intracellular bacteria or virus that after digestion replaces the invariant chain 
A) any foreign antigen presented to a T cell 
B) an alloantigen presented to a B cell 
C) an antigen that comes from outside the cell and has been engulfed by an antigen-presenting cell 
D) an antigen that comes from an intracellular bacteria or virus that after digestion replaces the invariant chain

Question 14

An adjuvant

Accepted Answer

A) is covalently attached to a carrier to form an immune response 
B) allows slow release of the antigen to increase immunogenicity 
C) is covalently attached to a hapten to form an immune response 
D) is an alloantigen on the immunoglobulin molecule 
A) is covalently attached to a carrier to form an immune response 
B) allows slow release of the antigen to increase immunogenicity 
C) is covalently attached to a hapten to form an immune response 
D) is an alloantigen on the immunoglobulin molecule

Question 15

The T cell receptor

Accepted Answer

A) is associated with the CD3 receptor on the cell surface 
B) binds soluble antigen 
C) only binds antigen which is presented by the correct MHC class I or II molecule 
D) A and B 
E) A and C 
A) is associated with the CD3 receptor on the cell surface 
B) binds soluble antigen 
C) only binds antigen which is presented by the correct MHC class I or II molecule 
D) A and B 
E) A and C

Question 16

Which of the following are either a and b or g and d, have a variable region that was formed through recombinational events, and are associated with the CD3 molecule ?

Accepted Answer

A) IgD molecules 
B) acute phase reactants 
C) pattern recognition receptors 
D) T-cell receptors 
A) IgD molecules 
B) acute phase reactants 
C) pattern recognition receptors 
D) T-cell receptors

Question 17

A heteroantigen is

Accepted Answer

A) an antigen from a different part on your own body 
B) an antigen from a different individual in your same species 
C) an antigen from another species that is recognized by surface carbohydrates and does not follow an evolutionary pattern of inheritance 
D) an antigen from a different species 
A) an antigen from a different part on your own body 
B) an antigen from a different individual in your same species 
C) an antigen from another species that is recognized by surface carbohydrates and does not follow an evolutionary pattern of inheritance 
D) an antigen from a different species

Question 18

Which of the following is true for cross-reactions? They

Accepted Answer

A) can hurt us because they can be related to autoimmune disease 
B) are the reason that we have anti-A or anti-B red blood cell antibodies 
C) cause the need for a very specific assay for HCG for pregnancy testing 
D) are used in vaccines 
E) can do all of the above 
A) can hurt us because they can be related to autoimmune disease 
B) are the reason that we have anti-A or anti-B red blood cell antibodies 
C) cause the need for a very specific assay for HCG for pregnancy testing 
D) are used in vaccines 
E) can do all of the above

Question 19

All cells in the body can get infected, and when infected, a cell presents the antigen of the infection. In which molecule does it present the antigen, and which type of cell responds?

Accepted Answer

A) class II molecule, CD4+ T cell 
B) class I molecule, CD8+ T cell 
C) immunoglobulin, NK cell 
D) PAMP, PRRs 
A) class II molecule, CD4+ T cell 
B) class I molecule, CD8+ T cell 
C) immunoglobulin, NK cell 
D) PAMP, PRRs

Question 20

Class I molecules are found on

Accepted Answer

A) every nucleated cell in your body 
B) red blood cells only 
C) monocytes, macrophage, dendritic cells, and B cells only 
D) B and C 
A) every nucleated cell in your body 
B) red blood cells only 
C) monocytes, macrophage, dendritic cells, and B cells only 
D) B and C

Exam 3: Antigens-Epitopes and Immunogenicity

An immunogen is a(n)

An antigen on an intracellular bacteria

Epitopes are the

An antigen on an extracellular bacterium

Which of the following is the most immunogenic?

An adjuvant is

If mom is HLA A2A9/B5B12/CW3CW5 and baby is A2A11/B5B18/Cw5Cw8, can a man who is A9A11/B8B18/CW5CW8 be the dad? Can a child who is A2A9/B5B18/Cw5Cw8 be the sibling without recombinational events?

It has been theorized that some viruses have antigens on their surfaces similar to human antigens, which can lead to the reaction of the immune system with self-antigens that are slightly different from the virus as the result of

Which of the following is the most immunogenic?

Which of the following contains factors involved in immunogenicity?

An alloantigen is

Class II molecules

An exogenous antigen is defined as

An adjuvant

The T cell receptor

Which of the following are either a and b or g and d, have a variable region that was formed through recombinational events, and are associated with the CD3 molecule ?

A heteroantigen is

Which of the following is true for cross-reactions? They

All cells in the body can get infected, and when infected, a cell presents the antigen of the infection. In which molecule does it present the antigen, and which type of cell responds?

Class I molecules are found on

Introduction to Immunology

Antibody

Cellular Immunity

Complement Pathways

Agglutination and Precipitation Reactions: the Unlabeled Immunoassays

Labeled Immunoassays

Serology Laboratory Math

Hypersensitivity Reactions

Autoimmunitysystemic

Autoimmunityorgan or Tissue Specific

Tumor Immunology

Hematopoeitc Malignancies

Immunology of Transplantation

Primary Immunodeficiency Diseases

Acquired Immunodeficiency Including Hiv and Aids

Hepatitis

Serology and Viruses Herpesviridae Family and Other Serologically

Bacterial Serology

Fungal Serology Parasitic Serology

Forensic Serology

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Molecular Biology

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