Question 1

Beta-2 microglobulin is part of the class I molecule, is elevated, and is a tumor marker in

Accepted Answer

A) multiple myeloma 
B) chronic lymphocytic leukemia 
C) some lymphomas 
D) all of the above 
E) none of the above 
A) multiple myeloma 
B) chronic lymphocytic leukemia 
C) some lymphomas 
D) all of the above 
E) none of the above D

Question 2

AFP-L1 and AFP-L3 differ because

Accepted Answer

A) AFP L-1 is a monomer and AFP-L-3 is a trimer 
B) AFP-L1 is associated with cancer 
C) AFP-L1 and AFP-L3 are different glycoforms of the same protein 
D) all of the above 
A) AFP L-1 is a monomer and AFP-L-3 is a trimer 
B) AFP-L1 is associated with cancer 
C) AFP-L1 and AFP-L3 are different glycoforms of the same protein 
D) all of the above C

Question 3

A patient has a lump in her breast that was diagnosed as breast cancer. Her physician should monitor the course of her treatment with

Accepted Answer

A) CA 15-3 and CA 125 
B) CA 125 and CA 27-29 
C) CA 15-3 and Cytokeratin 
D) CA 15-3 and CA 27-29 
A) CA 15-3 and CA 125 
B) CA 125 and CA 27-29 
C) CA 15-3 and Cytokeratin 
D) CA 15-3 and CA 27-29 D

Question 4

If I suspect that a patient has pancreatic cancer, I should use

Accepted Answer

A) CA 19-9 for diagnosis, staging, and monitoring the course of the disease 
B) CA19-9 for staging and monitoring the course of the disease only 
C) CA19-9 for monitoring the course of the disease only 
D) for monitoring the course of the disease 
A) CA 19-9 for diagnosis, staging, and monitoring the course of the disease 
B) CA19-9 for staging and monitoring the course of the disease only 
C) CA19-9 for monitoring the course of the disease only 
D) for monitoring the course of the disease

Question 5

Two cancer vaccines that are already on the market are

Accepted Answer

A) Gardisil, Prostatec 
B) Prostatec, Provenge 
C) Herceptin, Gardisil 
D) Gardisil, Provenge 
A) Gardisil, Prostatec 
B) Prostatec, Provenge 
C) Herceptin, Gardisil 
D) Gardisil, Provenge

Question 6

Circulating tumor cells in blood must be

Accepted Answer

A) isolated by anti-CD45, stained with anti-cytokeratins, but not stained with anti-EpCAM 
B) isolated by anti-EpCAM, stained with anti-CD45, but not stained with anticytokeratins 
C) isolated by anti-EpCAM, stained with anticytokeratins, but not stained with anti-CD45 
D) isolated by anti-cytokeratins, stained with anti-CD45, but not stained with anti-EpCAM 
A) isolated by anti-CD45, stained with anti-cytokeratins, but not stained with anti-EpCAM 
B) isolated by anti-EpCAM, stained with anti-CD45, but not stained with anticytokeratins 
C) isolated by anti-EpCAM, stained with anticytokeratins, but not stained with anti-CD45 
D) isolated by anti-cytokeratins, stained with anti-CD45, but not stained with anti-EpCAM

Question 7

LDH is

Accepted Answer

A) a marker for cell turnover 
B) used to stage nonseminomatous testicular cancer 
C) used to stage breast cancer 
D) A and B 
E) A and C 
A) a marker for cell turnover 
B) used to stage nonseminomatous testicular cancer 
C) used to stage breast cancer 
D) A and B 
E) A and C

Question 8

I am starting a company that produces a new screening test for pancreatic cancer. This disease is present in 1 in every 10,000 individuals, and my marker does not miss any of them! In testing normals, I find only 1 of every 100 individuals positive for my marker. There really is not a great chemotherapy for pancreatic cancer no matter when we find it. I am looking for venture capital for my test. Will you call your rich Uncle Freddie and tell him to invest?

Accepted Answer

A) No, the costs would be too high to screen 10,000 people to find one cancer. 
B) No, the costs would be too high to scare 100 people for every one cancer I found. 
C) No, there is no good chemotherapy for pancreatic cancer, so why find it? 
D) all of the above 
A) No, the costs would be too high to screen 10,000 people to find one cancer. 
B) No, the costs would be too high to scare 100 people for every one cancer I found. 
C) No, there is no good chemotherapy for pancreatic cancer, so why find it? 
D) all of the above

Question 9

Grading is a prognostic indicator that involves

Accepted Answer

A) determining how far a tumor has spread 
B) determining how many lymph nodes contain tumor cells 
C) determining how much the tumor looks like the tissue of origin and how much it looks like embryonic tissue 
D) using genotyping to determine whether a tumor is sensitive to chemotherapy 
A) determining how far a tumor has spread 
B) determining how many lymph nodes contain tumor cells 
C) determining how much the tumor looks like the tissue of origin and how much it looks like embryonic tissue 
D) using genotyping to determine whether a tumor is sensitive to chemotherapy

Question 10

A tumor that arises from supportive or connective tissue is called (best answer)

Accepted Answer

A) a carcinoma 
B) an adenocarcinoma 
C) a sarcoma 
D) a melanoma 
A) a carcinoma 
B) an adenocarcinoma 
C) a sarcoma 
D) a melanoma

Question 11

A tumor that is from nonglandular epithelial cells is called

Accepted Answer

A) a carcinoma 
B) an adenocarcinoma 
C) a sarcoma 
D) a melanoma 
A) a carcinoma 
B) an adenocarcinoma 
C) a sarcoma 
D) a melanoma

Question 12

Grading a tumor has to do with determining

Accepted Answer

A) how much DNA is in the tumor cell 
B) what the tumor cells look like, whether they look like embryonic cells, or they look the cells of the organ they came from 
C) how far the tumor has spread 
D) the number of risk factors a patient has 
A) how much DNA is in the tumor cell 
B) what the tumor cells look like, whether they look like embryonic cells, or they look the cells of the organ they came from 
C) how far the tumor has spread 
D) the number of risk factors a patient has

Question 13

Which of the following is correct?

Accepted Answer

A) Carcinomas can be detected in immunohistochemistry by cytokeratin staining, mesenchymal tumors can be detected by vimentin staining, and hematopoietic tumors can be detected by CD45 in them. 
B) Carcinomas can be detected in immunohistochemistry by vimentin staining, mesenchymal tumors can be detected by cytokeratin staining in them, and hematopoietic tumors can be detected by CD45 in them. 
C) Carcinomas can be detected in immunohistochemistry by cytokeratin staining, mesenchymal tumors can be detected by CD45 in them, and hematopoietic tumors can be detected by vimentin in them. 
D) Carcinomas can be detected in immunohistochemistry by CD45 staining, mesenchymal tumors can be detected by vimentin in them, and hematopoietic tumors can be detected by cytokeratin in them. 
A) Carcinomas can be detected in immunohistochemistry by cytokeratin staining, mesenchymal tumors can be detected by vimentin staining, and hematopoietic tumors can be detected by CD45 in them. 
B) Carcinomas can be detected in immunohistochemistry by vimentin staining, mesenchymal tumors can be detected by cytokeratin staining in them, and hematopoietic tumors can be detected by CD45 in them. 
C) Carcinomas can be detected in immunohistochemistry by cytokeratin staining, mesenchymal tumors can be detected by CD45 in them, and hematopoietic tumors can be detected by vimentin in them. 
D) Carcinomas can be detected in immunohistochemistry by CD45 staining, mesenchymal tumors can be detected by vimentin in them, and hematopoietic tumors can be detected by cytokeratin in them.

Question 14

Which of the following marker(s) is(are) used in breast cancer monitoring?

Accepted Answer

A) CA 19.9 
B) CA15-3 
C) CA27-29 
D) B and C 
E) all of the above 
A) CA 19.9 
B) CA15-3 
C) CA27-29 
D) B and C 
E) all of the above

Question 15

A tumor that is from glandular epithelial cells is called (best answer)

Accepted Answer

A) a carcinoma 
B) an adenocarcinoma 
C) a sarcoma 
D) a melanoma 
A) a carcinoma 
B) an adenocarcinoma 
C) a sarcoma 
D) a melanoma

Question 16

PSA velocity is

Accepted Answer

A) the amount that the velocity of a man's urine is slowed due to the pressure of the prostate tumor on the bladder 
B) the change in the PSA levels from one year's measurement to the next 
C) the amount of time it takes for PSA to double 
D) the rate that PSA comes to equilibrium in a centrifuge tube 
A) the amount that the velocity of a man's urine is slowed due to the pressure of the prostate tumor on the bladder 
B) the change in the PSA levels from one year's measurement to the next 
C) the amount of time it takes for PSA to double 
D) the rate that PSA comes to equilibrium in a centrifuge tube

Question 17

Which two of (1) Epstein Barr virus, (2) human papilloma virus, (3) rubella, and (4) varicella zoster have been associated with tumors?

Accepted Answer

A) 1 and 2 
B) 2 and 3 
C) 3 and 4 
D) 1 and 4 
A) 1 and 2 
B) 2 and 3 
C) 3 and 4 
D) 1 and 4

Question 18

The average time it takes a tumor to go from one transformed cell to the 1 cm size is

Accepted Answer

A) 6 months to 1 year 
B) 1 month to 6 months 
C) 5 to 8 years 
D) 10 to 12 years 
A) 6 months to 1 year 
B) 1 month to 6 months 
C) 5 to 8 years 
D) 10 to 12 years

Question 19

In this figure, l chemotherapy that turned out to be unsuccessful could have been initiated at which point?

Accepted Answer

A) A 
B) B 
C) C 
D) D 
E) E 
A) A 
B) B 
C) C 
D) D 
E) E

Question 20

Immunosurveillance of tumors involves

Accepted Answer

A) NK cells 
B) T cells 
C) antibody 
D) A and B 
E) all of the above 
A) NK cells 
B) T cells 
C) antibody 
D) A and B 
E) all of the above

Exam 12: Tumor Immunology

Beta-2 microglobulin is part of the class I molecule, is elevated, and is a tumor marker in

AFP-L1 and AFP-L3 differ because

A patient has a lump in her breast that was diagnosed as breast cancer. Her physician should monitor the course of her treatment with

If I suspect that a patient has pancreatic cancer, I should use

Two cancer vaccines that are already on the market are

Circulating tumor cells in blood must be

LDH is

Grading is a prognostic indicator that involves

A tumor that arises from supportive or connective tissue is called (best answer)

A tumor that is from nonglandular epithelial cells is called

Grading a tumor has to do with determining

Which of the following is correct?

Which of the following marker(s) is(are) used in breast cancer monitoring?

A tumor that is from glandular epithelial cells is called (best answer)

PSA velocity is

Which two of (1) Epstein Barr virus, (2) human papilloma virus, (3) rubella, and (4) varicella zoster have been associated with tumors?

The average time it takes a tumor to go from one transformed cell to the 1 cm size is

In this figure, l chemotherapy that turned out to be unsuccessful could have been initiated at which point?

Immunosurveillance of tumors involves

Introduction to Immunology

Antibody

Antigens-Epitopes and Immunogenicity

Cellular Immunity

Complement Pathways

Agglutination and Precipitation Reactions: the Unlabeled Immunoassays

Labeled Immunoassays

Serology Laboratory Math

Hypersensitivity Reactions

Autoimmunitysystemic

Autoimmunityorgan or Tissue Specific

Hematopoeitc Malignancies

Immunology of Transplantation

Primary Immunodeficiency Diseases

Acquired Immunodeficiency Including Hiv and Aids

Hepatitis

Serology and Viruses Herpesviridae Family and Other Serologically

Bacterial Serology

Fungal Serology Parasitic Serology

Forensic Serology

Safety

Molecular Biology

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