Question 1

Anti-CCP antibodies

Accepted Answer

A) are seen in all cases of rheumatoid arthritis and in people with chronic infections 
B) are seen in about 70% of cases of rheumatoid arthritis and are rarely seen in others 
C) are seen in all cases of rheumatoid arthritis and are rarely seen in others 
D) are found only in patients with rheumatoid arthritis and patients with Lyme disease 
A) are seen in all cases of rheumatoid arthritis and in people with chronic infections 
B) are seen in about 70% of cases of rheumatoid arthritis and are rarely seen in others 
C) are seen in all cases of rheumatoid arthritis and are rarely seen in others 
D) are found only in patients with rheumatoid arthritis and patients with Lyme disease B

Question 2

Central tolerance

Accepted Answer

A) involves regulatory T cells 
B) negative selection 
C) positive selection 
D) A and B 
E) B and C 
A) involves regulatory T cells 
B) negative selection 
C) positive selection 
D) A and B 
E) B and C E

Question 3

Autoimmunity

Accepted Answer

A) involves genetics 
B) can sometimes be gender associated 
C) can be hormone associated 
D) B and C 
E) all of the above 
A) involves genetics 
B) can sometimes be gender associated 
C) can be hormone associated 
D) B and C 
E) all of the above E

Question 4

Although some patients with other types of SLE have antibody to this nuclear antigen, the fact that 95% of patients with drug-induced Lupus have antibody to this particular antigen can be helpful if drug-induced lupus is suspected. The antigen is

Accepted Answer

A) Smith antigen 
B) RNP 
C) dsDNA 
D) histones 
E) none of the above 
A) Smith antigen 
B) RNP 
C) dsDNA 
D) histones 
E) none of the above

Question 5

What would the diagnosis of the patient in questions 5 and 6 be?

Accepted Answer

A) SLE 
B) rheumatoid factor 
C) Crohn's disease 
D) celiac disease 
E) Sjögren's syndrome 
A) SLE 
B) rheumatoid factor 
C) Crohn's disease 
D) celiac disease 
E) Sjögren's syndrome

Question 6

The specificity of the ANA test for SLE is

Accepted Answer

A) high; no other individuals have this antibody 
B) high except for patients who have rheumatoid arthritis 
C) low; other people have this antibody 
D) high if used in conjunction with anti-CCP 
A) high; no other individuals have this antibody 
B) high except for patients who have rheumatoid arthritis 
C) low; other people have this antibody 
D) high if used in conjunction with anti-CCP

Question 7

Monoclonal antibodies are used in the treatment of some autoimmune diseases including Crohn's and rheumatoid arthritis. This therapeutic antibody reacts with

Accepted Answer

A) TGF-beta 
B) TNF-alpha 
C) IL-2 
D) IL-6 
A) TGF-beta 
B) TNF-alpha 
C) IL-2 
D) IL-6

Question 8

Serum from CREST subset of systemic sclerosis in ANA testing shows

Accepted Answer

A) centromere staining 
B) speckled staining 
C) rim staining 
D) homogeneous staining 
A) centromere staining 
B) speckled staining 
C) rim staining 
D) homogeneous staining

Question 9

What percentage of the SLE patients is positive for antinuclear antibodies

Accepted Answer

A) 100 
B) 95 
C) 20 
D) 15 
A) 100 
B) 95 
C) 20 
D) 15

Question 10

SLE is

Accepted Answer

A) related to a single gene mutation 
B) made worse by exposure to sunlight 
C) due to inflammation caused by circulating immune complexes 
D) B and C 
E) all of the above 
A) related to a single gene mutation 
B) made worse by exposure to sunlight 
C) due to inflammation caused by circulating immune complexes 
D) B and C 
E) all of the above

Question 11

Antitopoisomerase antibody is the same as

Accepted Answer

A) anti-SS-A 
B) anti SS-B 
C) antihistones 
D) anti-Scl-70 
A) anti-SS-A 
B) anti SS-B 
C) antihistones 
D) anti-Scl-70

Question 12

Which antibody would you expect to be involved in the disease in question 5?

Accepted Answer

A) anti-dsDNA 
B) antitopoisomerase 
C) anti-SCL-70 
D) anti-SS-A and anti SS-B 
E) B and C 
A) anti-dsDNA 
B) antitopoisomerase 
C) anti-SCL-70 
D) anti-SS-A and anti SS-B 
E) B and C

Question 13

A pannus is

Accepted Answer

A) an area of continuous inflammation in the joint of someone with arthritis 
B) an area of inflammation in the kidney of someone with antidouble-stranded DNA 
C) reaction with Crithidia luciliae 
D) none of the above 
A) an area of continuous inflammation in the joint of someone with arthritis 
B) an area of inflammation in the kidney of someone with antidouble-stranded DNA 
C) reaction with Crithidia luciliae 
D) none of the above

Question 14

A patient comes into the clinic with a skin condition called scleroderma. Of the following, which pattern of ANA staining would you expect?

Accepted Answer

A) centromere 
B) peripheral 
C) nucleolar 
D) homogeneous 
A) centromere 
B) peripheral 
C) nucleolar 
D) homogeneous

Question 15

A patient comes into the clinic with dry eyes and dry mouth but no joint pain. Which pattern of ANA staining would you expect?

Accepted Answer

A) peripheral 
B) nucleolar 
C) speckled 
D) homogeneous 
A) peripheral 
B) nucleolar 
C) speckled 
D) homogeneous

Question 16

Which of the following is used for testing the specificity of the antibody in a patient suspected of having SLE?

Accepted Answer

A) ANA testing on HEP-2 cells 
B) ELISA testing 
C) testing on Crithidia luciliae 
D) all of the above 
E) A and B 
A) ANA testing on HEP-2 cells 
B) ELISA testing 
C) testing on Crithidia luciliae 
D) all of the above 
E) A and B

Question 17

Apoptosis is related to SLE because

Accepted Answer

A) the slow cleanup of apoptotic debris may lead to SLE 
B) lymphocytes that are self-reactive may not kill themselves 
C) cellular debris can lead to polyclonal activation of B cells 
D) all of the above 
A) the slow cleanup of apoptotic debris may lead to SLE 
B) lymphocytes that are self-reactive may not kill themselves 
C) cellular debris can lead to polyclonal activation of B cells 
D) all of the above

Question 18

In the latex agglutination assay for rheumatoid factor, the antigen coated on the latex beads is

Accepted Answer

A) CCP 
B) IgG with the Fc facing in 
C) IgG with the Fc facing out 
D) CCP and IgG with the Fc facing out 
A) CCP 
B) IgG with the Fc facing in 
C) IgG with the Fc facing out 
D) CCP and IgG with the Fc facing out

Question 19

An ANA that yields a speckled result requires a subsequent assay because any of the following antigens could be involved

Accepted Answer

A) dsDNA, nucleolus RNA, kinetochore 
B) RNP, ds DNA 
C) Sm, SS-A, SS-B, SCL-70, RNP 
D) RNP, nucleolar RNA, dsDNA, 
A) dsDNA, nucleolus RNA, kinetochore 
B) RNP, ds DNA 
C) Sm, SS-A, SS-B, SCL-70, RNP 
D) RNP, nucleolar RNA, dsDNA,

Question 20

Antibody to one of the nuclear antigens listed below, although it is in only about 10-25% of SLE patients, has such a high specificity that it is still used to aid in diagnosis. This antigen is

Accepted Answer

A) RNP 
B) Sm 
C) ds DNA 
D) histones 
A) RNP 
B) Sm 
C) ds DNA 
D) histones

Exam 10: Autoimmunitysystemic

Anti-CCP antibodies

Central tolerance

Autoimmunity

Although some patients with other types of SLE have antibody to this nuclear antigen, the fact that 95% of patients with drug-induced Lupus have antibody to this particular antigen can be helpful if drug-induced lupus is suspected. The antigen is

What would the diagnosis of the patient in questions 5 and 6 be?

The specificity of the ANA test for SLE is

Monoclonal antibodies are used in the treatment of some autoimmune diseases including Crohn's and rheumatoid arthritis. This therapeutic antibody reacts with

Serum from CREST subset of systemic sclerosis in ANA testing shows

What percentage of the SLE patients is positive for antinuclear antibodies

SLE is

Antitopoisomerase antibody is the same as

Which antibody would you expect to be involved in the disease in question 5?

A pannus is

A patient comes into the clinic with a skin condition called scleroderma. Of the following, which pattern of ANA staining would you expect?

A patient comes into the clinic with dry eyes and dry mouth but no joint pain. Which pattern of ANA staining would you expect?

Which of the following is used for testing the specificity of the antibody in a patient suspected of having SLE?

Apoptosis is related to SLE because

In the latex agglutination assay for rheumatoid factor, the antigen coated on the latex beads is

An ANA that yields a speckled result requires a subsequent assay because any of the following antigens could be involved

Antibody to one of the nuclear antigens listed below, although it is in only about 10-25% of SLE patients, has such a high specificity that it is still used to aid in diagnosis. This antigen is

Introduction to Immunology

Antibody

Antigens-Epitopes and Immunogenicity

Cellular Immunity

Complement Pathways

Agglutination and Precipitation Reactions: the Unlabeled Immunoassays

Labeled Immunoassays

Serology Laboratory Math

Hypersensitivity Reactions

Autoimmunityorgan or Tissue Specific

Tumor Immunology

Hematopoeitc Malignancies

Immunology of Transplantation

Primary Immunodeficiency Diseases

Acquired Immunodeficiency Including Hiv and Aids

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Serology and Viruses Herpesviridae Family and Other Serologically

Bacterial Serology

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