Question 1

Cortisol and aldosterone insufficiency develop in which of the following diseases?

Accepted Answer

A) Grave's disease 
B) Hashimoto's disease 
C) Addison's disease 
D) celiac disease 
A) Grave's disease 
B) Hashimoto's disease 
C) Addison's disease 
D) celiac disease C

Question 2

Detection of 21-hydroxylase autoantibodies occurs in which of the following diseases?

Accepted Answer

A) celiac 
B) Crohn's 
C) type 1 diabetes mellitus 
D) Addison's 
A) celiac 
B) Crohn's 
C) type 1 diabetes mellitus 
D) Addison's D

Question 3

How should the patient in question 1 be treated?

Accepted Answer

A) placed on a gluten-free diet 
B) given thyroid hormone replacement therapy 
C) treat the symptoms, which sometimes resolves the situation 
D) given replacement therapy with glucocorticoids and mineralocorticoids 
A) placed on a gluten-free diet 
B) given thyroid hormone replacement therapy 
C) treat the symptoms, which sometimes resolves the situation 
D) given replacement therapy with glucocorticoids and mineralocorticoids B

Question 4

ANCA

Accepted Answer

A) stands for antinuclear and cytoplasmic antibodies 
B) stands for antineutrophil cytoplasmic antigens 
C) aids in the diagnosis of vasculitic diseases 
D) A and C 
E) B and C 
A) stands for antinuclear and cytoplasmic antibodies 
B) stands for antineutrophil cytoplasmic antigens 
C) aids in the diagnosis of vasculitic diseases 
D) A and C 
E) B and C

Question 5

A student in the class always is complaining that she's cold, she's tired, she's been gaining weight but says she just doesn't care about anything anymore. The semester has been tough, and although you feel guilty, at first you ignore her, but just now as you looked up, her neck appears to be enlarged in the front and her skin and hair look dry. What do you think she might have?

Accepted Answer

A) Grave's disease 
B) Hashimoto's disease 
C) Addison's disease 
D) Celiac disease 
A) Grave's disease 
B) Hashimoto's disease 
C) Addison's disease 
D) Celiac disease

Question 6

Antibodies against the yeast species Saccharomyces cervesiae are found in which of the following diseases?

Accepted Answer

A) celiac 
B) Crohn's 
C) autoimmune hepatitis 
D) Addison's 
A) celiac 
B) Crohn's 
C) autoimmune hepatitis 
D) Addison's

Question 7

Another student has an odd-looking blistery rash and has been losing weight. You and she are good friends, but must she tell you about her bowel symptoms? She has diarrhea and cramping. What do you think she might have?

Accepted Answer

A) Grave's disease 
B) Hashimoto's disease 
C) Addison's disease 
D) Celiac disease 
A) Grave's disease 
B) Hashimoto's disease 
C) Addison's disease 
D) Celiac disease

Question 8

IgA autoantibodies against gliadin, tissue transglutaminase, and endomysium are found in patients which of the following diseases?

Accepted Answer

A) celiac 
B) Crohn's 
C) type 1 diabetes mellitus 
D) Addison's 
A) celiac 
B) Crohn's 
C) type 1 diabetes mellitus 
D) Addison's

Question 9

The disease in question 15 is

Accepted Answer

A) multiple sclerosis 
B) Addison's disease 
C) Grave's disease 
D) myasthenia gravis 
E) type 1 diabetes 
A) multiple sclerosis 
B) Addison's disease 
C) Grave's disease 
D) myasthenia gravis 
E) type 1 diabetes

Question 10

Your grandmother has blisters in her mouth. At first you thought that they are just canker sores, but now they have spread to her scalp! She has always been so proud of her looks and is upset. These are huge blisters, bigger than 1 cm in diameter, and they burst easily. In making a diagnosis, for what should her physician look?

Accepted Answer

A) a skin biopsy by direct immunofluorescence 
B) indirect enzyme immunoassay 
C) a skin biopsy by indirect immunofluorescence 
D) A or B 
E) A or C 
A) a skin biopsy by direct immunofluorescence 
B) indirect enzyme immunoassay 
C) a skin biopsy by indirect immunofluorescence 
D) A or B 
E) A or C

Question 11

What should you test to determine the diagnosis of the student in question 1?

Accepted Answer

A) IgA against tissue transglutaminase 
B) autoantibodies targeting the adrenal cortex 
C) antibody to thyroid hormone-stimulating receptor, triiodothyronine and thyroxine (T3 and T4), levels 
D) triiodothyronine and thyroxine (T3 and T 4) levels and antibodies to thyroglobulin and thyroperoxidase 
A) IgA against tissue transglutaminase 
B) autoantibodies targeting the adrenal cortex 
C) antibody to thyroid hormone-stimulating receptor, triiodothyronine and thyroxine (T3 and T4), levels 
D) triiodothyronine and thyroxine (T3 and T 4) levels and antibodies to thyroglobulin and thyroperoxidase

Question 12

Venous and arterial clots are associated with

Accepted Answer

A) anti-CCP 
B) rheumatoid factor 
C) antiphospholipid antibody 
D) A and B 
E) B and C 
A) anti-CCP 
B) rheumatoid factor 
C) antiphospholipid antibody 
D) A and B 
E) B and C

Question 13

What should you look for to determine the diagnosis in your grandmother in question 12?

Accepted Answer

A) IgA against tissue transglutaminase 
B) antidesmoglein antibodies by direct immunofluorescence of a skin biopsy near the blisters 
C) BP180 and BP230 antibodies by direct immunofluorescence of a skin biopsy near the blisters 
D) antibodies to acetylcholine by EIA of her serum 
A) IgA against tissue transglutaminase 
B) antidesmoglein antibodies by direct immunofluorescence of a skin biopsy near the blisters 
C) BP180 and BP230 antibodies by direct immunofluorescence of a skin biopsy near the blisters 
D) antibodies to acetylcholine by EIA of her serum

Question 14

Antibodies to glutamic acid decarboxylase-65, insulin-associated antigen, and insulin found are found in which of the following diseases?

Accepted Answer

A) celiac 
B) Crohn's 
C) type 1 diabetes mellitus 
D) Addison's 
A) celiac 
B) Crohn's 
C) type 1 diabetes mellitus 
D) Addison's

Question 15

Antibody-mediated destruction of the acetylcholine receptor at the postsynaptic membrane of the neuromuscular junction occurs in which of the following diseases?

Accepted Answer

A) multiple sclerosis 
B) Addison's 
C) biliary cirrhosis 
D) myasthenia gravis 
A) multiple sclerosis 
B) Addison's 
C) biliary cirrhosis 
D) myasthenia gravis

Question 16

Autoantibodies against sperm

Accepted Answer

A) are found bound to the sperm in a binding assay with latex beads that have anti-IgG on their surface 
B) are found bound to the sperm in a binding assay with latex beads that have anti-IgA on their surface 
C) A and B 
D) none of the above 
A) are found bound to the sperm in a binding assay with latex beads that have anti-IgG on their surface 
B) are found bound to the sperm in a binding assay with latex beads that have anti-IgA on their surface 
C) A and B 
D) none of the above

Question 17

How should the patient in questions 9 and 10 be treated?

Accepted Answer

A) placed on a gluten-free diet 
B) given thyroid hormone replacement therapy 
C) treat the symptoms, which sometimes resolves the situation 
D) given replacement therapy with glucocorticoids and mineralocorticoids 
A) placed on a gluten-free diet 
B) given thyroid hormone replacement therapy 
C) treat the symptoms, which sometimes resolves the situation 
D) given replacement therapy with glucocorticoids and mineralocorticoids

Question 18

Antibodies found in type 1 insulin-dependent diabetes include

Accepted Answer

A) glutamic acid decarboxylase-65 (GAD-65), insulin-associated antigen, and insulin 
B) catecholamines, desmoglein, and insulin 
C) transglutaminase, insulin and insulin-associated antigen 
D) myelin basic protein, transglutaminase, and insulin 
A) glutamic acid decarboxylase-65 (GAD-65), insulin-associated antigen, and insulin 
B) catecholamines, desmoglein, and insulin 
C) transglutaminase, insulin and insulin-associated antigen 
D) myelin basic protein, transglutaminase, and insulin

Question 19

Dry eyes and mouth are symptoms of which of the following diseases?

Accepted Answer

A) scleroderma 
B) myasthenia gravis 
C) Sjögren's syndrome 
D) systemic sclerosis 
A) scleroderma 
B) myasthenia gravis 
C) Sjögren's syndrome 
D) systemic sclerosis

Question 20

ANCA is found in

Accepted Answer

A) type 1 diabetes 
B) Hashimoto's disease 
C) SLE 
D) Wegener's granulomatosis 
A) type 1 diabetes 
B) Hashimoto's disease 
C) SLE 
D) Wegener's granulomatosis

Exam 11: Autoimmunityorgan or Tissue Specific

Cortisol and aldosterone insufficiency develop in which of the following diseases?

Detection of 21-hydroxylase autoantibodies occurs in which of the following diseases?

How should the patient in question 1 be treated?

ANCA

Antibodies against the yeast species Saccharomyces cervesiae are found in which of the following diseases?

Another student has an odd-looking blistery rash and has been losing weight. You and she are good friends, but must she tell you about her bowel symptoms? She has diarrhea and cramping. What do you think she might have?

IgA autoantibodies against gliadin, tissue transglutaminase, and endomysium are found in patients which of the following diseases?

The disease in question 15 is

What should you test to determine the diagnosis of the student in question 1?

Venous and arterial clots are associated with

What should you look for to determine the diagnosis in your grandmother in question 12?

Antibodies to glutamic acid decarboxylase-65, insulin-associated antigen, and insulin found are found in which of the following diseases?

Antibody-mediated destruction of the acetylcholine receptor at the postsynaptic membrane of the neuromuscular junction occurs in which of the following diseases?

Autoantibodies against sperm

How should the patient in questions 9 and 10 be treated?

Antibodies found in type 1 insulin-dependent diabetes include

Dry eyes and mouth are symptoms of which of the following diseases?

ANCA is found in

Introduction to Immunology

Antibody

Antigens-Epitopes and Immunogenicity

Cellular Immunity

Complement Pathways

Agglutination and Precipitation Reactions: the Unlabeled Immunoassays

Labeled Immunoassays

Serology Laboratory Math

Hypersensitivity Reactions

Autoimmunitysystemic

Tumor Immunology

Hematopoeitc Malignancies

Immunology of Transplantation

Primary Immunodeficiency Diseases

Acquired Immunodeficiency Including Hiv and Aids

Hepatitis

Serology and Viruses Herpesviridae Family and Other Serologically

Bacterial Serology

Fungal Serology Parasitic Serology

Forensic Serology

Safety

Molecular Biology

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