Question 1

Which is involved in immune complex clearance by phagocytosis or splenic clearance?

Accepted Answer

A) CR1 
B) CR2 
C) CR3 
D) CR1 and CR3 
A) CR1 
B) CR2 
C) CR3 
D) CR1 and CR3 A

Question 2

If the CH50 is lower than normal but the AH50 is normal, which set contains the components that could be involved?

Accepted Answer

A) factor B, factor D, and Properdin 
B) MBL, MASP-1, MASP-2 
C) C1, C4, C2, C1INH 
D) C5-9 
A) factor B, factor D, and Properdin 
B) MBL, MASP-1, MASP-2 
C) C1, C4, C2, C1INH 
D) C5-9 C

Question 3

Complement proteins are involved in all of the following except

Accepted Answer

A) host defense 
B) immune complex clearance 
C) interaction with the coagulation pathway 
D) lattice formation 
E) enhancement of memory 
A) host defense 
B) immune complex clearance 
C) interaction with the coagulation pathway 
D) lattice formation 
E) enhancement of memory D

Question 4

Individual complement components measured with

Accepted Answer

A) AH50 
B) CH50 
C) RID 
D) bacterial cell lysis 
A) AH50 
B) CH50 
C) RID 
D) bacterial cell lysis

Question 5

The factors in the alternative pathway that are involved in the progression of the pathway are_______ and ___________. The factors that are involved in inhibition of the pathway are _____ and _________.

Accepted Answer

A) Factor C and D , Factor Properdin and Factor I 
B) Factor B and D , Factor E and F 
C) Factor B and D, Factor ficolin and Factor I 
D) Factor B and D, Factor H and I 
A) Factor C and D , Factor Properdin and Factor I 
B) Factor B and D , Factor E and F 
C) Factor B and D, Factor ficolin and Factor I 
D) Factor B and D, Factor H and I

Question 6

To study antibody in a patient's blood in a way that removes the complement,

Accepted Answer

A) freeze and thaw the serum 
B) use serum instead of plasma 
C) add LPS and then heat to 100°C for 2 minutes 
D) heat the serum to 56oC for 30 minutes 
A) freeze and thaw the serum 
B) use serum instead of plasma 
C) add LPS and then heat to 100°C for 2 minutes 
D) heat the serum to 56oC for 30 minutes

Question 7

C-reactive protein can

Accepted Answer

A) activate complement in the classical pathway 
B) activate complement in the lectin pathway 
C) activate complement in the alternative pathway 
D) activate complement in the classical pathway and activate complement in the alternative pathway 
A) activate complement in the classical pathway 
B) activate complement in the lectin pathway 
C) activate complement in the alternative pathway 
D) activate complement in the classical pathway and activate complement in the alternative pathway

Question 8

Which of the following are all opsonic molecules?

Accepted Answer

A) C3b, C1q, iC3b, C4b 
B) C2a, C1q, C3b 
C) C2b, C3b, C4b 
D) C3b, C4b, C9 
A) C3b, C1q, iC3b, C4b 
B) C2a, C1q, C3b 
C) C2b, C3b, C4b 
D) C3b, C4b, C9

Question 9

Because a particular antigen is far on the bacteria from another antigen, antibodies binding to these antigens

Accepted Answer

A) would activate complement only if antibodies bound to them underwent a comformational shift 
B) would activate complement only if antibodies bound to them were close enough for the Fc regions of the bound antibodies to bind different globular heads of the C1q molecule 
C) would activate complement only if antibodies bound to them underwent a comformational shift and would activate complement only if antibodies bound to them were close enough for the Fc regions of the bound antibodies to bind different globular heads of the C1q molecule 
D) none of the above 
A) would activate complement only if antibodies bound to them underwent a comformational shift 
B) would activate complement only if antibodies bound to them were close enough for the Fc regions of the bound antibodies to bind different globular heads of the C1q molecule 
C) would activate complement only if antibodies bound to them underwent a comformational shift and would activate complement only if antibodies bound to them were close enough for the Fc regions of the bound antibodies to bind different globular heads of the C1q molecule 
D) none of the above

Question 10

Complement can lyse which of the following cells?

Accepted Answer

A) fungal cells 
B) gram-positive bacteria 
C) gram-negative bacteria 
D) all of the above 
A) fungal cells 
B) gram-positive bacteria 
C) gram-negative bacteria 
D) all of the above

Question 11

Which of the following has a short half-life unless it lands on the cell surface?

Accepted Answer

A) C4b 
B) C2b 
C) C5a 
D) C3a 
A) C4b 
B) C2b 
C) C5a 
D) C3a

Question 12

C1q can

Accepted Answer

A) bind free-floating IgM that is not bound to antigen 
B) become activated after interaction with one surface-bound antibody 
C) bind after a conformational change occurs as the result of antigen binding 
D) bind IgG4 
A) bind free-floating IgM that is not bound to antigen 
B) become activated after interaction with one surface-bound antibody 
C) bind after a conformational change occurs as the result of antigen binding 
D) bind IgG4

Question 13

Complement has

Accepted Answer

A) about 9 different proteins that are synthesized by monocytes 
B) about 35 different proteins that are synthesized by monocytes 
C) about 9 different proteins that are synthesized by monocytes, the liver, macrophages, and epithelial cells 
D) about 35 different proteins that are synthesized by monocytes, the liver, macrophages, and epithelial cells 
A) about 9 different proteins that are synthesized by monocytes 
B) about 35 different proteins that are synthesized by monocytes 
C) about 9 different proteins that are synthesized by monocytes, the liver, macrophages, and epithelial cells 
D) about 35 different proteins that are synthesized by monocytes, the liver, macrophages, and epithelial cells

Question 14

Which of the following is correct?

Accepted Answer

A) C1INH inactivates C1 and inhibits binding of MBL to MASP-2. 
B) factor D inhibits factor B and Properdin. 
C) DAF inhibits C1q binding to C1r and C1s. 
D) CR2 inhibits C3b formation. 
A) C1INH inactivates C1 and inhibits binding of MBL to MASP-2. 
B) factor D inhibits factor B and Properdin. 
C) DAF inhibits C1q binding to C1r and C1s. 
D) CR2 inhibits C3b formation.

Question 15

Inhibitors of complement include

Accepted Answer

A) factors I, H, and C1INH 
B) vitronectin or S protein 
C) CR3 
D) factors I, H, and C1INH and vitronectin or S protein 
E) All of the above 
A) factors I, H, and C1INH 
B) vitronectin or S protein 
C) CR3 
D) factors I, H, and C1INH and vitronectin or S protein 
E) All of the above

Question 16

Which of the following are anaphylatoxins?

Accepted Answer

A) C1q, C2a, C4a 
B) C2b, C4a, C5a 
C) C2a, C4a, C5a 
D) C3a, C4a, C5a 
A) C1q, C2a, C4a 
B) C2b, C4a, C5a 
C) C2a, C4a, C5a 
D) C3a, C4a, C5a

Question 17

The three different pathways of complement activation are

Accepted Answer

A) different until the C5 convertase is formed 
B) different until the membrane attack complex forms 
C) different until activation of C3 
D) different until C6 convertase forms 
A) different until the C5 convertase is formed 
B) different until the membrane attack complex forms 
C) different until activation of C3 
D) different until C6 convertase forms

Question 18

Properdin is a

Accepted Answer

A) complemencomponent of the classical pathway 
B) complement protein of the alternative pathway 
C) complement protein of the lectin pathway 
D) defensin 
A) complemencomponent of the classical pathway 
B) complement protein of the alternative pathway 
C) complement protein of the lectin pathway 
D) defensin

Question 19

Calcium ions are required

Accepted Answer

A) to keep C4bC2a together 
B) to keep C6,7,8 together 
C) to allow C9 to polymerize 
D) to keep C1q,r,s together 
A) to keep C4bC2a together 
B) to keep C6,7,8 together 
C) to allow C9 to polymerize 
D) to keep C1q,r,s together

Question 20

We would expect that a patient who has chronic liver disease would have complement levels that would be

Accepted Answer

A) elevated 
B) normal 
C) decreased 
D) indeterminate because there is too little information 
A) elevated 
B) normal 
C) decreased 
D) indeterminate because there is too little information

Exam 5: Complement Pathways

Which is involved in immune complex clearance by phagocytosis or splenic clearance?

If the CH50 is lower than normal but the AH50 is normal, which set contains the components that could be involved?

Complement proteins are involved in all of the following except

Individual complement components measured with

The factors in the alternative pathway that are involved in the progression of the pathway are_______ and ___________. The factors that are involved in inhibition of the pathway are _____ and _________.

To study antibody in a patient's blood in a way that removes the complement,

C-reactive protein can

Which of the following are all opsonic molecules?

Because a particular antigen is far on the bacteria from another antigen, antibodies binding to these antigens

Complement can lyse which of the following cells?

Which of the following has a short half-life unless it lands on the cell surface?

C1q can

Complement has

Which of the following is correct?

Inhibitors of complement include

Which of the following are anaphylatoxins?

The three different pathways of complement activation are

Properdin is a

Calcium ions are required

We would expect that a patient who has chronic liver disease would have complement levels that would be

Introduction to Immunology

Antibody

Antigens-Epitopes and Immunogenicity

Cellular Immunity

Agglutination and Precipitation Reactions: the Unlabeled Immunoassays

Labeled Immunoassays

Serology Laboratory Math

Hypersensitivity Reactions

Autoimmunitysystemic

Autoimmunityorgan or Tissue Specific

Tumor Immunology

Hematopoeitc Malignancies

Immunology of Transplantation

Primary Immunodeficiency Diseases

Acquired Immunodeficiency Including Hiv and Aids

Hepatitis

Serology and Viruses Herpesviridae Family and Other Serologically

Bacterial Serology

Fungal Serology Parasitic Serology

Forensic Serology

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Molecular Biology

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The factors in the alternative pathway that are involved in the progression of the pathway are_ and ___. The factors that are involved in inhibition of the pathway are _ and _______.