Question 1

Detection of antibodies present in the recipient that will react with donor antigens

Accepted Answer

A) is not necessary because immunosuppression can take care of this 
B) is performed using a luminex multiplex procedure 
C) is performed using a mixed lymphocyte reaction 
D) is performed using antibodies from women who have been pregnant multiple times 
A) is not necessary because immunosuppression can take care of this 
B) is performed using a luminex multiplex procedure 
C) is performed using a mixed lymphocyte reaction 
D) is performed using antibodies from women who have been pregnant multiple times B

Question 2

A xenograft is a graft from

Accepted Answer

A) an individual of the same species 
B) an identical twin 
C) one part of a patient's body to another part 
D) a different species 
A) an individual of the same species 
B) an identical twin 
C) one part of a patient's body to another part 
D) a different species D

Question 3

Beads used in the multiplex system are

Accepted Answer

A) coated with HLA antigens and incubated with the patient's serum to determine whether the patient has antibodies to different HLA types 
B) coated with the patient serum and incubated with the donor's lymphocytes to determine whether the patient has antibody to the donor's HLA type 
C) coated with HLA antigens and incubated with the donor's serum to determine whether the donor has antibodies to different HLA types 
D) coated with the donor's serum and incubated with the recipient's lymphocytes to determine whether the donor has antibody to the recipient's HLA type 
A) coated with HLA antigens and incubated with the patient's serum to determine whether the patient has antibodies to different HLA types 
B) coated with the patient serum and incubated with the donor's lymphocytes to determine whether the patient has antibody to the donor's HLA type 
C) coated with HLA antigens and incubated with the donor's serum to determine whether the donor has antibodies to different HLA types 
D) coated with the donor's serum and incubated with the recipient's lymphocytes to determine whether the donor has antibody to the recipient's HLA type A

Question 4

An autograft is a graft from

Accepted Answer

A) an individual of the same species 
B) an identical twin 
C) one part of a patient's body to another part 
D) a different species 
A) an individual of the same species 
B) an identical twin 
C) one part of a patient's body to another part 
D) a different species

Question 5

In graft-versus-host disease,

Accepted Answer

A) a kidney transplant releases toxic products that affect the host 
B) a liver transplant releases toxic products that affect the host 
C) the bone marrow transplant attacks the recipient as being foreign 
D) the recipient sends cells and molecules to attack the bone marrow 
A) a kidney transplant releases toxic products that affect the host 
B) a liver transplant releases toxic products that affect the host 
C) the bone marrow transplant attacks the recipient as being foreign 
D) the recipient sends cells and molecules to attack the bone marrow

Question 6

The universal donor

Accepted Answer

A) A+ Rh+ 
B) B+ Rh+ 
C) O Rh+ 
D) O Rh- 
A) A+ Rh+ 
B) B+ Rh+ 
C) O Rh+ 
D) O Rh-

Question 7

A first set rejection is

Accepted Answer

A) an antibody-mediated graft rejection 
B) the rejection of the allograft at first encounter 
C) the rejection of the allograft after a second encounter 
D) the rejection that is due to ABO antigens 
A) an antibody-mediated graft rejection 
B) the rejection of the allograft at first encounter 
C) the rejection of the allograft after a second encounter 
D) the rejection that is due to ABO antigens

Question 8

A microcytotoxicity test performed in transplantation involves

Accepted Answer

A) antibody to ABO antigens + complement-killing endothelial cells 
B) white blood cells from the donor mixed with antibodies to HLA antigens and complement 
C) white blood cells from the recipient mixed with antibodies to HLA antigens and complement 
D) B and C 
E) A and B 
A) antibody to ABO antigens + complement-killing endothelial cells 
B) white blood cells from the donor mixed with antibodies to HLA antigens and complement 
C) white blood cells from the recipient mixed with antibodies to HLA antigens and complement 
D) B and C 
E) A and B

Question 9

Acute graft rejection is mediated by

Accepted Answer

A) antibodies 
B) neutrophils 
C) T cells 
D) A and B 
E) A and C 
A) antibodies 
B) neutrophils 
C) T cells 
D) A and B 
E) A and C

Question 10

To determine class II molecule compatibility of a transplant,

Accepted Answer

A) mixed lymphocyte reactions were once performed, but now genotyping is performed 
B) mixed lymphocyte reactions were once performed, but now flow cytometry is performed 
C) microcytotoxicity was once performed, but now the primary test is flow cytometry 
D) none of the above 
A) mixed lymphocyte reactions were once performed, but now genotyping is performed 
B) mixed lymphocyte reactions were once performed, but now flow cytometry is performed 
C) microcytotoxicity was once performed, but now the primary test is flow cytometry 
D) none of the above

Question 11

Cyclosporin A blocks

Accepted Answer

A) B-cell reaction with a transplant 
B) antibody reaction with a transplant 
C) T-cell receptor signaling IL-2 production 
D) antigen-presenting cells 
A) B-cell reaction with a transplant 
B) antibody reaction with a transplant 
C) T-cell receptor signaling IL-2 production 
D) antigen-presenting cells

Question 12

An allograft is a graft from

Accepted Answer

A) an individual of the same species 
B) an identical twin 
C) one part of a patient's body to another part 
D) a different species 
A) an individual of the same species 
B) an identical twin 
C) one part of a patient's body to another part 
D) a different species

Question 13

Hyperacute rejection on the operating table is due to

Accepted Answer

A) T cells that react with class I molecules on the donated organ 
B) T cells that react to class II molecules on the donated organ 
C) donor T cells that react to the recipient lymphocytes 
D) antibody in the recipient that reacts to donor antigens 
A) T cells that react with class I molecules on the donated organ 
B) T cells that react to class II molecules on the donated organ 
C) donor T cells that react to the recipient lymphocytes 
D) antibody in the recipient that reacts to donor antigens

Question 14

Symptoms of graft-versus-host disease can include

Accepted Answer

A) diarrhea 
B) rashes 
C) pneumonitis 
D) A and B 
E) all of the above 
A) diarrhea 
B) rashes 
C) pneumonitis 
D) A and B 
E) all of the above

Question 15

A cross match done at 37º C will detect which of the following against the donor cells?

Accepted Answer

A) all antibodies 
B) IgG 
C) IgM 
D) IgA 
A) all antibodies 
B) IgG 
C) IgM 
D) IgA

Question 16

Viruses for which donors should be screened are

Accepted Answer

A) hepatitis B, hepatitis C, HIV 
B) hepatitis B, hepatitis C, HIV, West Nile virus 
C) hepatitis B, hepatitis C, HIV, West Nile virus, human T-lymphotropic virus (HTLV) 
D) hepatitis B, hepatitis C, HIV, West Nile virus, rubella 
A) hepatitis B, hepatitis C, HIV 
B) hepatitis B, hepatitis C, HIV, West Nile virus 
C) hepatitis B, hepatitis C, HIV, West Nile virus, human T-lymphotropic virus (HTLV) 
D) hepatitis B, hepatitis C, HIV, West Nile virus, rubella

Question 17

Acute rejection can be decreased by

Accepted Answer

A) plasmapheresis 
B) immunosuppressive drugs such as Rituxan 
C) a better match 
D) A and C 
E) B and C 
A) plasmapheresis 
B) immunosuppressive drugs such as Rituxan 
C) a better match 
D) A and C 
E) B and C

Question 18

Chronic rejection

Accepted Answer

A) can be prevented by immunosuppressant drugs 
B) involves T cells only 
C) involves humoral and cell-mediated responses and other mechanisms 
D) plays only a minor role in the overall acceptance or rejection of a transplanted organ 
A) can be prevented by immunosuppressant drugs 
B) involves T cells only 
C) involves humoral and cell-mediated responses and other mechanisms 
D) plays only a minor role in the overall acceptance or rejection of a transplanted organ

Question 19

ABO blood group antigens are found on

Accepted Answer

A) red blood cells 
B) lymphocytes 
C) endothelial cells 
D) A and B 
E) all of the above 
A) red blood cells 
B) lymphocytes 
C) endothelial cells 
D) A and B 
E) all of the above

Question 20

Markers for stem cells include

Accepted Answer

A) CD34 
B) CD 44 
C) CD 133 
D) A and B 
E) A and C 
A) CD34 
B) CD 44 
C) CD 133 
D) A and B 
E) A and C

Exam 14: Immunology of Transplantation

Detection of antibodies present in the recipient that will react with donor antigens

A xenograft is a graft from

Beads used in the multiplex system are

An autograft is a graft from

In graft-versus-host disease,

The universal donor

A first set rejection is

A microcytotoxicity test performed in transplantation involves

Acute graft rejection is mediated by

To determine class II molecule compatibility of a transplant,

Cyclosporin A blocks

An allograft is a graft from

Hyperacute rejection on the operating table is due to

Symptoms of graft-versus-host disease can include

A cross match done at 37º C will detect which of the following against the donor cells?

Viruses for which donors should be screened are

Acute rejection can be decreased by

Chronic rejection

ABO blood group antigens are found on

Markers for stem cells include

Introduction to Immunology

Antibody

Antigens-Epitopes and Immunogenicity

Cellular Immunity

Complement Pathways

Agglutination and Precipitation Reactions: the Unlabeled Immunoassays

Labeled Immunoassays

Serology Laboratory Math

Hypersensitivity Reactions

Autoimmunitysystemic

Autoimmunityorgan or Tissue Specific

Tumor Immunology

Hematopoeitc Malignancies

Primary Immunodeficiency Diseases

Acquired Immunodeficiency Including Hiv and Aids

Hepatitis

Serology and Viruses Herpesviridae Family and Other Serologically

Bacterial Serology

Fungal Serology Parasitic Serology

Forensic Serology

Safety

Molecular Biology

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