Question 1

Borrelia burgdorferi

Accepted Answer

A) can evade the immune response for years 
B) causes the production of an immune response that is responsible for some of the pathology of Lyme disease 
C) is generally transmitted only if the tick holds on and feeds for at least 24 hours 
D) all of the above 
E) none of the above 
A) can evade the immune response for years 
B) causes the production of an immune response that is responsible for some of the pathology of Lyme disease 
C) is generally transmitted only if the tick holds on and feeds for at least 24 hours 
D) all of the above 
E) none of the above D

Question 2

Syphilis is detected first by a(n) _________ or a(n)_________ and then if that is positive by __________ or _____________.

Accepted Answer

A) Western blot, sandwich assay, antigen capture assay, RIBA 
B) antigen capture assay, sandwich assay, western blot, RIBA 
C) VDRL, FTA-ABS, RPR, microhemagglutination after absorption 
D) VDRL, RPR, FTA-ABS, microhemagglutination after absorption 
A) Western blot, sandwich assay, antigen capture assay, RIBA 
B) antigen capture assay, sandwich assay, western blot, RIBA 
C) VDRL, FTA-ABS, RPR, microhemagglutination after absorption 
D) VDRL, RPR, FTA-ABS, microhemagglutination after absorption D

Question 3

Rebecca Lancefield classified beta hemolytic streptococci according to their

Accepted Answer

A) surface lipids 
B) surface proteins 
C) antibiotic resistance 
D) surface carbohydrates 
E) C and D 
A) surface lipids 
B) surface proteins 
C) antibiotic resistance 
D) surface carbohydrates 
E) C and D D

Question 4

The CDC recommendation for diagnosis of Lyme disease is to use

Accepted Answer

A) direct immunofluorescence on an organism obtained from EM rash 
B) indirect immunofluorescence with patient serum on slides with the Borrelia 
C) enzyme immunoassay followed by a western blot 
D) Ouchterlony 
A) direct immunofluorescence on an organism obtained from EM rash 
B) indirect immunofluorescence with patient serum on slides with the Borrelia 
C) enzyme immunoassay followed by a western blot 
D) Ouchterlony

Question 5

The Abs in the FTA-ABS test stands for

Accepted Answer

A) absorption with pathogenic strain organisms 
B) absorption with nonpathogenic strain organisms 
C) antibody agglutination with pathogenic strain organisms 
D) antibody agglutination with nonpathogenic strain organisms 
A) absorption with pathogenic strain organisms 
B) absorption with nonpathogenic strain organisms 
C) antibody agglutination with pathogenic strain organisms 
D) antibody agglutination with nonpathogenic strain organisms

Question 6

What is(are) the antigen(s) used for an RPR test?

Accepted Answer

A) cardiolipin, lecithin, and cholesterol on carbon particles 
B) cardiolipin in an alcohol base 
C) lecithin on carbon particles 
D) phospholipid, lecithin, and cholesterol in an alcohol and PBS base 
A) cardiolipin, lecithin, and cholesterol on carbon particles 
B) cardiolipin in an alcohol base 
C) lecithin on carbon particles 
D) phospholipid, lecithin, and cholesterol in an alcohol and PBS base

Question 7

Group A strep

Accepted Answer

A) causes the strep throat that we all have had, which is nothing to worry about 
B) causes diseases as the result of cross-reactive antigens such as rheumatic fever 
C) can cause diseases due to cross-reactive antigens such as glomerulonephritis 
D) can cause disease due to cross-reactive antigens such as toxic shock syndrome 
A) causes the strep throat that we all have had, which is nothing to worry about 
B) causes diseases as the result of cross-reactive antigens such as rheumatic fever 
C) can cause diseases due to cross-reactive antigens such as glomerulonephritis 
D) can cause disease due to cross-reactive antigens such as toxic shock syndrome

Question 8

In what way(s) is the RPR test easier than the VDRL test?

Accepted Answer

A) the antigen used is at a very dilute concentration 
B) the antiserum can be used at a very dilute concentration 
C) the serum does not need to be heat inactivated 
D) all of the above 
A) the antigen used is at a very dilute concentration 
B) the antiserum can be used at a very dilute concentration 
C) the serum does not need to be heat inactivated 
D) all of the above

Question 9

Mycoplasma pneumonia is not susceptible to the beta lactam antibiotics because

Accepted Answer

A) it contains a plasmid that has an enzyme that breaks them down 
B) its cell wall has an extra double bond in the cell wall that they cannot break 
C) it does not contain the peptidoglycan cell wall 
D) none of the above 
A) it contains a plasmid that has an enzyme that breaks them down 
B) its cell wall has an extra double bond in the cell wall that they cannot break 
C) it does not contain the peptidoglycan cell wall 
D) none of the above

Question 10

For what fluid the RPR test not be used?

Accepted Answer

A) heat-inactivated serum 
B) cerebral spinal fluid 
C) plasma 
D) all of the above are acceptable samples 
A) heat-inactivated serum 
B) cerebral spinal fluid 
C) plasma 
D) all of the above are acceptable samples

Question 11

To test for Helicobacter pylori by a less invasive method, you can

Accepted Answer

A) take a biopsy during endoscopy and do a rapid urease test 
B) take a biopsy and do a bacterial culture 
C) look for serum levels of IgM to H. pylori antigens and for H. pylori antigens in urine or stool 
D) look for serum levels of IgG to H. pylori antigens and for H. pylori antigens in urine or stool 
E) none of the above 
A) take a biopsy during endoscopy and do a rapid urease test 
B) take a biopsy and do a bacterial culture 
C) look for serum levels of IgM to H. pylori antigens and for H. pylori antigens in urine or stool 
D) look for serum levels of IgG to H. pylori antigens and for H. pylori antigens in urine or stool 
E) none of the above

Question 12

Which of these organisms has diverse shapes and are spread by insects?

Accepted Answer

A) Clostridium 
B) Helicobacteria 
C) Mycoplasma 
D) Rickettsia 
A) Clostridium 
B) Helicobacteria 
C) Mycoplasma 
D) Rickettsia

Question 13

Lyme disease

Accepted Answer

A) has a primary, secondary, and tertiary stages that are distinct and always separated 
B) is diagnosed using a western blot as the screening assay 
C) always has ECM, a visible rash 
D) has some pathology caused by the immune system 
A) has a primary, secondary, and tertiary stages that are distinct and always separated 
B) is diagnosed using a western blot as the screening assay 
C) always has ECM, a visible rash 
D) has some pathology caused by the immune system

Question 14

Helicobacter pylori is detected by

Accepted Answer

A) invasive testing including biopsy 
B) a 14C breath test that shows the functioning of the bacteria urease 
C) stool testing for antigen in the feces 
D) all of the above 
E) none of the above 
A) invasive testing including biopsy 
B) a 14C breath test that shows the functioning of the bacteria urease 
C) stool testing for antigen in the feces 
D) all of the above 
E) none of the above

Question 15

Which assay is more specific?

Accepted Answer

A) the cold agglutination reaction for M. pneumoniae 
B) the presumptive test for infectious mononucleosis 
C) the VDRL test for syphilis 
D) the use of indirect immunofluorescence to detect antibodies to M. pneumoniae 
E) the use of Proteus vulgaris antigens to diagnose Rickettsia 
A) the cold agglutination reaction for M. pneumoniae 
B) the presumptive test for infectious mononucleosis 
C) the VDRL test for syphilis 
D) the use of indirect immunofluorescence to detect antibodies to M. pneumoniae 
E) the use of Proteus vulgaris antigens to diagnose Rickettsia

Question 16

Rheumatic fever is caused when

Accepted Answer

A) when antibodies that cross-react with host tissue are formed after a strep infection 
B) when an endotoxin produced by S. pyogenes has its effect 
C) just after the appearance of strawberry tongue 
D) B and C 
A) when antibodies that cross-react with host tissue are formed after a strep infection 
B) when an endotoxin produced by S. pyogenes has its effect 
C) just after the appearance of strawberry tongue 
D) B and C

Question 17

Toxic shock syndrome is produced when

Accepted Answer

A) the M protein of strep interacts with host tissue 
B) hyaluronidase activates T cells 
C) a toxin acts as a superantigen, causing the polyclonal activation of T cells 
D) A and B 
E) B and C 
A) the M protein of strep interacts with host tissue 
B) hyaluronidase activates T cells 
C) a toxin acts as a superantigen, causing the polyclonal activation of T cells 
D) A and B 
E) B and C

Question 18

Treponema pallidum

Accepted Answer

A) causes the development of a very painful chancre in primary syphilis 
B) causes the development of wartlike growths called condyloma latum in tertiary syphilis 
C) can be tested in a VDRL, a screening assay with heat-inactivated serum 
D) can be tested in a screening assay called microhemagglutination 
A) causes the development of a very painful chancre in primary syphilis 
B) causes the development of wartlike growths called condyloma latum in tertiary syphilis 
C) can be tested in a VDRL, a screening assay with heat-inactivated serum 
D) can be tested in a screening assay called microhemagglutination

Question 19

Because an elderly nursing home patient had aspiration pneumonia, she was on antibiotic therapy for several days. However she suddenly developed diarrhea that smells very bad. What do you think the patient has?

Accepted Answer

A) Clostridium difficile 
B) Helicobacter pylori 
C) Mycoplasma pneumonia 
D) Streptococcus pyogenes 
A) Clostridium difficile 
B) Helicobacter pylori 
C) Mycoplasma pneumonia 
D) Streptococcus pyogenes

Question 20

Clostridium difficile assays can involve

Accepted Answer

A) enzyme immunoassays for the toxin A and B antigens 
B) enzyme immunoassays for antibody to the toxin A and B antigens 
C) enhancement of the cytopathic effect of the virus by addition of antiserum 
D) none of the above 
A) enzyme immunoassays for the toxin A and B antigens 
B) enzyme immunoassays for antibody to the toxin A and B antigens 
C) enhancement of the cytopathic effect of the virus by addition of antiserum 
D) none of the above

Exam 19: Bacterial Serology

Borrelia burgdorferi

Syphilis is detected first by a(n) _________ or a(n)_________ and then if that is positive by __________ or _____________.

Rebecca Lancefield classified beta hemolytic streptococci according to their

The CDC recommendation for diagnosis of Lyme disease is to use

The Abs in the FTA-ABS test stands for

What is(are) the antigen(s) used for an RPR test?

Group A strep

In what way(s) is the RPR test easier than the VDRL test?

Mycoplasma pneumonia is not susceptible to the beta lactam antibiotics because

For what fluid the RPR test not be used?

To test for Helicobacter pylori by a less invasive method, you can

Which of these organisms has diverse shapes and are spread by insects?

Lyme disease

Helicobacter pylori is detected by

Which assay is more specific?

Rheumatic fever is caused when

Toxic shock syndrome is produced when

Treponema pallidum

Because an elderly nursing home patient had aspiration pneumonia, she was on antibiotic therapy for several days. However she suddenly developed diarrhea that smells very bad. What do you think the patient has?

Clostridium difficile assays can involve

Introduction to Immunology

Antibody

Antigens-Epitopes and Immunogenicity

Cellular Immunity

Complement Pathways

Agglutination and Precipitation Reactions: the Unlabeled Immunoassays

Labeled Immunoassays

Serology Laboratory Math

Hypersensitivity Reactions

Autoimmunitysystemic

Autoimmunityorgan or Tissue Specific

Tumor Immunology

Hematopoeitc Malignancies

Immunology of Transplantation

Primary Immunodeficiency Diseases

Acquired Immunodeficiency Including Hiv and Aids

Hepatitis

Serology and Viruses Herpesviridae Family and Other Serologically

Fungal Serology Parasitic Serology

Forensic Serology

Safety

Molecular Biology

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Syphilis is detected first by a(n) _____ or a(n)_ and then if that is positive by or _______.